《新英格兰医学杂志》（New England Journal of Medicine）3月10日发表的ROADMAP研究结果显示,血管紧张素Ⅱ受体拮抗剂奥美沙坦可延缓2型糖尿病患者发生微量白蛋白尿的时间,但同时也会增加原有心血管疾病的患者发生致死性心血管事件的...《新英格兰医学杂志》（New England Journal of Medicine）3月10日发表的ROADMAP研究结果显示,血管紧张素Ⅱ受体拮抗剂奥美沙坦可延缓2型糖尿病患者发生微量白蛋白尿的时间,但同时也会增加原有心血管疾病的患者发生致死性心血管事件的风险（N Engl J Med,2011,364：907-917）。ROADMAP研究是一项随机、双盲、多中心对照临床试验。纳入的4447例2型糖尿病患者,随机分配进行奥美沙坦（40mg/d）或安慰剂治疗,展开更多
The aim of this study was to examine the importance of glycemic regulation on the risk of preterm delivery in women with normoal buminuria and no preeclampsia later in pregnancy. Study design and methods: A prospectiv...The aim of this study was to examine the importance of glycemic regulation on the risk of preterm delivery in women with normoal buminuria and no preeclampsia later in pregnancy. Study design and methods: A prospective study of 71 women with type 1 diabetes mellitus where complete data were collected on HbA1c, insulin dose, and albumin excretion rate from week 12 and every second week hereafter. Fundus photography was performed and diurnal blood pressure measured three times during pregnancy. Results: The preterm rate was 23% and women delivering preterm showed higher HbA1c throughout pregnancy. At regression analysis HbA1c was the strongest predictor for preterm delivery from week 6 to 32, also when including insulin dose, BMI, age, duration of diabetes, and diurnal blood pressure. The risk of delivering preterm was more than 40% when HbA1c was above 7.7% in week 8. Diurnal blood pressure was not found associated with preterm delivery. Conclusion: The quality of glycemic regulation in the early and mid pregnancy is a major, independent risk factor for preterm delivery in normoalbuminuric diabetic women without preeclampsia.展开更多
文摘《新英格兰医学杂志》（New England Journal of Medicine）3月10日发表的ROADMAP研究结果显示,血管紧张素Ⅱ受体拮抗剂奥美沙坦可延缓2型糖尿病患者发生微量白蛋白尿的时间,但同时也会增加原有心血管疾病的患者发生致死性心血管事件的风险（N Engl J Med,2011,364：907-917）。ROADMAP研究是一项随机、双盲、多中心对照临床试验。纳入的4447例2型糖尿病患者,随机分配进行奥美沙坦（40mg/d）或安慰剂治疗,
文摘The aim of this study was to examine the importance of glycemic regulation on the risk of preterm delivery in women with normoal buminuria and no preeclampsia later in pregnancy. Study design and methods: A prospective study of 71 women with type 1 diabetes mellitus where complete data were collected on HbA1c, insulin dose, and albumin excretion rate from week 12 and every second week hereafter. Fundus photography was performed and diurnal blood pressure measured three times during pregnancy. Results: The preterm rate was 23% and women delivering preterm showed higher HbA1c throughout pregnancy. At regression analysis HbA1c was the strongest predictor for preterm delivery from week 6 to 32, also when including insulin dose, BMI, age, duration of diabetes, and diurnal blood pressure. The risk of delivering preterm was more than 40% when HbA1c was above 7.7% in week 8. Diurnal blood pressure was not found associated with preterm delivery. Conclusion: The quality of glycemic regulation in the early and mid pregnancy is a major, independent risk factor for preterm delivery in normoalbuminuric diabetic women without preeclampsia.
