A sulfonated 9,10-distyrylanthracene derivative with aggregation-induced emission (AIE) property is designed and synthesized. It shows a highly sensitive and selective fluorescence enhancement property for bovine seru...A sulfonated 9,10-distyrylanthracene derivative with aggregation-induced emission (AIE) property is designed and synthesized. It shows a highly sensitive and selective fluorescence enhancement property for bovine serum albumin (BSA) protein detection and quantification. Analysis on the interaction between the probe molecule and BSA reveals the essential role of the hydrophobic cavities of the protein folding structure.展开更多
Objective： To observe the effects of electroacupuncutre at Tianzhu point on the expressions ofbcl-2 and bcl-XL in the degenerative cervical intervertebral disc of rats. Methods Forty SD male rats were randomly divide...Objective： To observe the effects of electroacupuncutre at Tianzhu point on the expressions ofbcl-2 and bcl-XL in the degenerative cervical intervertebral disc of rats. Methods Forty SD male rats were randomly divided into 4 groups, sham surgery group, model group, Western medicine group and electroacuptmcture group, there were 10 rats in each group. Except for rats in the sham surgery group, rats in the other groups were made to be of cervical intervertebral disc degeneration by unbalanced dynamic and static forces. Rats in the electroacupunture group were treated with electroacupuncture at Tianzhu （BL 10） and Dazhu （BL 11） points, while rats in the Western medicine group with Fenbid, and rats in the model group were not treated. After 30-day treatments, the expressions of bcl-2 and bcl-XL were observed with immunohisto-chemical method in the cervical intervertebral disc. Results： The expression of bcl-2 was higher in the electroacupuncture, sham surgery, and western medicine groups than that in the model group （P〈0.01）, whereas, there was no difference among these three groups. The expression of bcl-XL in the electroacupuncture group was lower than that in the sham surgery group （P〈0.01）, and higher than those in the Western medicine group and model group （P〈0.01）. Conclusion： Electroacupuncture treatment can enhance the expressions of bcl-2 and bcl-XL, which may be the mechanism of delaying the cell apoptosis in the intervertebral disc to treat diseases.展开更多
基金the National Basic Research Pro- gram of China (973 Program, 2013CB834702, 2009CB623605)the Natural Science Foundation of China (21074045, 21204027, 21221063)+1 种基金the Research Fund for the Doctoral Program of Higher Education of China (20120061120016)the Project of Jilin Province (20100704)
文摘A sulfonated 9,10-distyrylanthracene derivative with aggregation-induced emission (AIE) property is designed and synthesized. It shows a highly sensitive and selective fluorescence enhancement property for bovine serum albumin (BSA) protein detection and quantification. Analysis on the interaction between the probe molecule and BSA reveals the essential role of the hydrophobic cavities of the protein folding structure.
基金Shanghai Leading Academic Discipline Project(S30304)
文摘Objective： To observe the effects of electroacupuncutre at Tianzhu point on the expressions ofbcl-2 and bcl-XL in the degenerative cervical intervertebral disc of rats. Methods Forty SD male rats were randomly divided into 4 groups, sham surgery group, model group, Western medicine group and electroacuptmcture group, there were 10 rats in each group. Except for rats in the sham surgery group, rats in the other groups were made to be of cervical intervertebral disc degeneration by unbalanced dynamic and static forces. Rats in the electroacupunture group were treated with electroacupuncture at Tianzhu （BL 10） and Dazhu （BL 11） points, while rats in the Western medicine group with Fenbid, and rats in the model group were not treated. After 30-day treatments, the expressions of bcl-2 and bcl-XL were observed with immunohisto-chemical method in the cervical intervertebral disc. Results： The expression of bcl-2 was higher in the electroacupuncture, sham surgery, and western medicine groups than that in the model group （P〈0.01）, whereas, there was no difference among these three groups. The expression of bcl-XL in the electroacupuncture group was lower than that in the sham surgery group （P〈0.01）, and higher than those in the Western medicine group and model group （P〈0.01）. Conclusion： Electroacupuncture treatment can enhance the expressions of bcl-2 and bcl-XL, which may be the mechanism of delaying the cell apoptosis in the intervertebral disc to treat diseases.
