The term ‘baboon syndrome’(BS) was introduced 20 years ago to classify patie nts in whom a specific skin eruption resembling the red gluteal area of baboons occurred aftersy stemic exposure to contact allergens. The...The term ‘baboon syndrome’(BS) was introduced 20 years ago to classify patie nts in whom a specific skin eruption resembling the red gluteal area of baboons occurred aftersy stemic exposure to contact allergens. Thereafter, similar erupt ions have been reported after systemic exposure to beta-lactam antibiotics and other drugs. In addition to the presentation of 2 of our own cases, we have revi ewed and characterized the main clinical and histological aspects of published r eports of drug-related baboon syndrome (DRBS) and compared the primary clinical signs from such cases to those found in other distinct drug eruptions. Of appro ximately 100 published baboon syndrome cases, 50 were identified as drug-induce d. Of these, 8 were representatives of systemically induced contact dermatitis ( SCD), and 42 were examples of drug eruptions elicited by systemic administration of either oral or intravenous drugs. The main clinical findings included a shar ply defined symmetrical erythema of the gluteal area and in the flexural or inte rtriginousfolds without any systemic symptoms and signs. 14 of 42 cases were eli cited by amoxicillin, 30 of the 42 patients were male, and latency periods were between a few hours and a few days after exposure. DRBS is a rare, prognosticall y benign and often underdiagnosed drug eruption with distinct clinical features. The term baboon syndrome, however, does not reflect the complete range of sympt oms and signs and is ethically and culturally problematic. Moreover, baboon synd rome is historically often equated with a mercury-induced exanthem in patients with previous contact sensitization. Symmetrical drug-related intertriginous an d flexural exanthema, or SDRIFE, specifically refers to the distinctive clinical pattern of this drug eruption, and the following diagnostic criteria are propos ed:1)exposure to a systemically administered drug either at the first or repeat ed dose (excluding contact allergens); 2) sharply demarcated erythema of the glu teal/perianalareaand/orV-shaped erythema of the inguinal/perigenital area; 3) i nvolvement of at least one other intertriginous/flexural localization; 4) symmet ry of affected areas; and 5) absence of systemic symptoms and signs.展开更多
猪皮炎肾病综合征（Porcine dermatitis and nephropathy syndrome,PDNS）最早于1993年在英国被报道为一种在育肥猪中零星散发的条件性疾病。而现在此病证实是由猪圆环病毒（pcv-2）引起，主要危害生长猪和肥育猪，在哺乳仔猪阶段也偶...猪皮炎肾病综合征（Porcine dermatitis and nephropathy syndrome,PDNS）最早于1993年在英国被报道为一种在育肥猪中零星散发的条件性疾病。而现在此病证实是由猪圆环病毒（pcv-2）引起，主要危害生长猪和肥育猪，在哺乳仔猪阶段也偶有发现，造成猪只生长速度缓慢、饲料报酬降低，死亡率上升，而且猪群发病后由于免疫功能受到抑制，展开更多
猪的皮炎肾病综合征（Porcine Dermatitis and Nephropathy Syndrome，PDNS）是一种新的传染病，1993年首次报道在英国发生，随后在加拿大、西班牙、意大利、荷兰、美国、法国等国均有报道。2002年王忠田和杨汉春在“我国规模化养猪场...猪的皮炎肾病综合征（Porcine Dermatitis and Nephropathy Syndrome，PDNS）是一种新的传染病，1993年首次报道在英国发生，随后在加拿大、西班牙、意大利、荷兰、美国、法国等国均有报道。2002年王忠田和杨汉春在“我国规模化养猪场圆环病毒2型（PCV2）感染的流行病学调查”中首次报道广东一猪群中有此病。展开更多
文摘The term ‘baboon syndrome’(BS) was introduced 20 years ago to classify patie nts in whom a specific skin eruption resembling the red gluteal area of baboons occurred aftersy stemic exposure to contact allergens. Thereafter, similar erupt ions have been reported after systemic exposure to beta-lactam antibiotics and other drugs. In addition to the presentation of 2 of our own cases, we have revi ewed and characterized the main clinical and histological aspects of published r eports of drug-related baboon syndrome (DRBS) and compared the primary clinical signs from such cases to those found in other distinct drug eruptions. Of appro ximately 100 published baboon syndrome cases, 50 were identified as drug-induce d. Of these, 8 were representatives of systemically induced contact dermatitis ( SCD), and 42 were examples of drug eruptions elicited by systemic administration of either oral or intravenous drugs. The main clinical findings included a shar ply defined symmetrical erythema of the gluteal area and in the flexural or inte rtriginousfolds without any systemic symptoms and signs. 14 of 42 cases were eli cited by amoxicillin, 30 of the 42 patients were male, and latency periods were between a few hours and a few days after exposure. DRBS is a rare, prognosticall y benign and often underdiagnosed drug eruption with distinct clinical features. The term baboon syndrome, however, does not reflect the complete range of sympt oms and signs and is ethically and culturally problematic. Moreover, baboon synd rome is historically often equated with a mercury-induced exanthem in patients with previous contact sensitization. Symmetrical drug-related intertriginous an d flexural exanthema, or SDRIFE, specifically refers to the distinctive clinical pattern of this drug eruption, and the following diagnostic criteria are propos ed:1)exposure to a systemically administered drug either at the first or repeat ed dose (excluding contact allergens); 2) sharply demarcated erythema of the glu teal/perianalareaand/orV-shaped erythema of the inguinal/perigenital area; 3) i nvolvement of at least one other intertriginous/flexural localization; 4) symmet ry of affected areas; and 5) absence of systemic symptoms and signs.
文摘猪皮炎肾病综合征（Porcine dermatitis and nephropathy syndrome,PDNS）最早于1993年在英国被报道为一种在育肥猪中零星散发的条件性疾病。而现在此病证实是由猪圆环病毒（pcv-2）引起，主要危害生长猪和肥育猪，在哺乳仔猪阶段也偶有发现，造成猪只生长速度缓慢、饲料报酬降低，死亡率上升，而且猪群发病后由于免疫功能受到抑制，
文摘猪的皮炎肾病综合征（Porcine Dermatitis and Nephropathy Syndrome，PDNS）是一种新的传染病，1993年首次报道在英国发生，随后在加拿大、西班牙、意大利、荷兰、美国、法国等国均有报道。2002年王忠田和杨汉春在“我国规模化养猪场圆环病毒2型（PCV2）感染的流行病学调查”中首次报道广东一猪群中有此病。
