Locating the mineral processing plant near a mine is the most important parameter that affects the whole process.Many factors,and their preferences,should be considered in this stage.The factors include economical,geo...Locating the mineral processing plant near a mine is the most important parameter that affects the whole process.Many factors,and their preferences,should be considered in this stage.The factors include economical,geological,technical,environmental and tectonic parameters.A multi-criteria decision making method is necessary to rank the alternatives.In this paper we describe how plant location is selected by using the Analytic Hierarchy Process(AHP).This method,with eight criteria,was used to select a location for the mineral processing plant at the Sangan iron ore mine(phase 1).Three alternatives for the processing plant were evaluated.The main criteria were distance from the mine,access to heavy machinery transport,the amount of excavation required for grading,bed mixture capacity,belt conveyor length,distance from the tailing dam,distance from the waste dumps and surface water diversion requirements.Finally,the alternatives were ranked and the best location was proposed.展开更多
Based on a macroscopic mean-field model associating with the thalamus and cerebral cortex, we investigate how the newly proposed coordinated reset stimulation(CRS) strategy controls the absence seizures as some key pa...Based on a macroscopic mean-field model associating with the thalamus and cerebral cortex, we investigate how the newly proposed coordinated reset stimulation(CRS) strategy controls the absence seizures as some key parameters are changed.Different from the previous stimulation processes, CRS represents the intermittent pulse current administered to different structures including cortex, specific relay nuclei(SRN) and thalamus reticular nucleus(TRN) at different time by using three different micro-electrodes. In particular, we first simulate a typical absence epilepsy activity under the combined effect of the coupling strength between inhibitory interneurons(IIN)-excitatory pyramidal neurons(EPN) and EPN-TRN pathway. And then we explore the control mechanism of different parameters of 3:2 ON-OFF CRS on spike and slow-wave discharges(SWDs)region. Through analyzing the corresponding two-dimensional bifurcation diagrams, we find CRS is effective on controlling absence seizures in proper ranges of stimulation parameters. Especially, the combination of frequency and positive input duration can inhibit the pathological area more effectively. The obtained results might be helpful to study the pathophysiology mechanism of epilepsy, although the CRS's feasibility still needs further exploration in clinical experiments.展开更多
Spinal cord injury(SCI),which is much in the public eye,is still a refractory disease compromising the well-being of both patients and society.In spite of there being many methods dealing with the lesion,there is stil...Spinal cord injury(SCI),which is much in the public eye,is still a refractory disease compromising the well-being of both patients and society.In spite of there being many methods dealing with the lesion,there is still a deficiency in comprehensive strategies covering all facets of this damage.Further,we should also mention the structure called the corticospinal tract(CST)which plays a crucial role in the motor responses of organisms,and it will be the focal point of our attention.In this review,we discuss a variety of strategies targeting different dimensions following SCI and some treatments that are especially efficacious to the CST are emphasized.Over recent decades,researchers have developed many effective tactics involving five approaches:(1)tackle more extensive regions;(2)provide a regenerative microenvironment;(3)provide a glial microenvironment;(4)transplantation;and(5)other auxiliary methods,for instance,rehabilitation training and electrical stimulation.We review the basic knowledge on this disease and correlative treatments.In addition,some well-formulated perspectives and hypotheses have been delineated.We emphasize that such a multifaceted problem needs combinatorial approaches,and we analyze some discrepancies in past studies.Finally,for the future,we present numerous brand-new latent tactics which have great promise for curbing SCI.展开更多
In this article,we review the recent progress in active control of a turbulent boundary layer for skin-friction drag reduction.Near-wall coherent structures,which are closely associated with large skin-friction drag a...In this article,we review the recent progress in active control of a turbulent boundary layer for skin-friction drag reduction.Near-wall coherent structures,which are closely associated with large skin-friction drag and are thus often the target to be manipulated,are discussed briefly,providing a rationale of various control strategies.Open-and closed-loop controls are extensively reviewed,largely focusing on techniques and drag-reduction mechanisms.Finally,some concluding remarks are given.展开更多
文摘Locating the mineral processing plant near a mine is the most important parameter that affects the whole process.Many factors,and their preferences,should be considered in this stage.The factors include economical,geological,technical,environmental and tectonic parameters.A multi-criteria decision making method is necessary to rank the alternatives.In this paper we describe how plant location is selected by using the Analytic Hierarchy Process(AHP).This method,with eight criteria,was used to select a location for the mineral processing plant at the Sangan iron ore mine(phase 1).Three alternatives for the processing plant were evaluated.The main criteria were distance from the mine,access to heavy machinery transport,the amount of excavation required for grading,bed mixture capacity,belt conveyor length,distance from the tailing dam,distance from the waste dumps and surface water diversion requirements.Finally,the alternatives were ranked and the best location was proposed.
基金supported by the National Natural Science Foundation of China(Grant Nos.11325208 and 11572015)
文摘Based on a macroscopic mean-field model associating with the thalamus and cerebral cortex, we investigate how the newly proposed coordinated reset stimulation(CRS) strategy controls the absence seizures as some key parameters are changed.Different from the previous stimulation processes, CRS represents the intermittent pulse current administered to different structures including cortex, specific relay nuclei(SRN) and thalamus reticular nucleus(TRN) at different time by using three different micro-electrodes. In particular, we first simulate a typical absence epilepsy activity under the combined effect of the coupling strength between inhibitory interneurons(IIN)-excitatory pyramidal neurons(EPN) and EPN-TRN pathway. And then we explore the control mechanism of different parameters of 3:2 ON-OFF CRS on spike and slow-wave discharges(SWDs)region. Through analyzing the corresponding two-dimensional bifurcation diagrams, we find CRS is effective on controlling absence seizures in proper ranges of stimulation parameters. Especially, the combination of frequency and positive input duration can inhibit the pathological area more effectively. The obtained results might be helpful to study the pathophysiology mechanism of epilepsy, although the CRS's feasibility still needs further exploration in clinical experiments.
基金Project supported by the National Natural Science Foundation of China(Nos.81472504,81401822,and 81572177)the Science and Technology Foundation of Zhejiang Province(No.2016C33151)+1 种基金the Medical Science and Technology Project of Zhejiang Province of China(Nos.2016146428,2016KYA096,and 2017KY071)the Zhejiang Provincial Natural Science Foundation of China(Nos.Y17H160033,LQ14H060002,and LY14H060004)
文摘Spinal cord injury(SCI),which is much in the public eye,is still a refractory disease compromising the well-being of both patients and society.In spite of there being many methods dealing with the lesion,there is still a deficiency in comprehensive strategies covering all facets of this damage.Further,we should also mention the structure called the corticospinal tract(CST)which plays a crucial role in the motor responses of organisms,and it will be the focal point of our attention.In this review,we discuss a variety of strategies targeting different dimensions following SCI and some treatments that are especially efficacious to the CST are emphasized.Over recent decades,researchers have developed many effective tactics involving five approaches:(1)tackle more extensive regions;(2)provide a regenerative microenvironment;(3)provide a glial microenvironment;(4)transplantation;and(5)other auxiliary methods,for instance,rehabilitation training and electrical stimulation.We review the basic knowledge on this disease and correlative treatments.In addition,some well-formulated perspectives and hypotheses have been delineated.We emphasize that such a multifaceted problem needs combinatorial approaches,and we analyze some discrepancies in past studies.Finally,for the future,we present numerous brand-new latent tactics which have great promise for curbing SCI.
基金supported by the Research Grants Council of HKSAR (Grant No. PolyU 5350/10E)
文摘In this article,we review the recent progress in active control of a turbulent boundary layer for skin-friction drag reduction.Near-wall coherent structures,which are closely associated with large skin-friction drag and are thus often the target to be manipulated,are discussed briefly,providing a rationale of various control strategies.Open-and closed-loop controls are extensively reviewed,largely focusing on techniques and drag-reduction mechanisms.Finally,some concluding remarks are given.
