伊曲康唑冲击治疗皮肤播散性红色毛癣菌病1例

伊曲康唑400mg/天，连续一周冲击治疗，辅以增强免疫功能及对症治疗，治愈皮肤播散性红色毛癣菌病一例。皮损和组织真菌镜俭和培养均为阴性。随访十月，未复发。

红色毛癣菌引起的深在囊状癣

A 57-year-old Japanese woman developed multiple subcutaneous cysts located on the pubic region, thighs, back, and buttocks. She had been treated with systemic prednisolone and azathioprine for 3 years because of autoimmune hepatitis. Histologic examination revealed that the lesions were pseudocysts with numerous spores and hyphae. Trichophyton rubrum was identified in culture from the content of several examined cysts. The serum beta-D-glucan level was high (313 pg/mL), and a computed tomographic scan of the chest cavity showed infective embolism in the lung. To our best knowledge, this is the first reported case of multiple-cystic tinea profunda,presumably with systemic dermatophyte infection. Systemic T-cell immunosuppression, as represented by a relatively low percentage of memory T cells and negative delayed-type hypersensitivity tests, is considered to cause this rare manifestation of dermatophytosis.

真菌病

20110829毛孢子菌病/夏克宽(北京军区总院全军皮肤病诊治中心),杨蓉娅∥实用皮肤病学杂志.-2010,3(4).-215~217,2202001年杨蓉娅等报道了国内首例播散性毛孢子菌病。毛孢子菌感染已成为除念珠菌外致人类播散性感染的第二大酵母菌感染,致人类感染的有6种,最常见最重要的为阿萨希毛孢子菌(T.asahii)。可致皮肤。

与“真菌”战斗到底

手足癣是最常见的皮肤癣病之一。中医称手癣为“鹅掌风”。足癣俗称“脚气”．“脚湿气”．“香港脚”。手足癣是致病性真菌（如红色毛癣菌、絮状表皮癣菌）感染指（趾）间及掌跖皮肤所致。近几年来，白色念珠菌及其他酵母样菌感染也屡见不鲜。手、足癣根据症状不同分为三型：水疱型。瘙痒较重。往往由于搔抓而继发感染，可引起丹毒和淋巴管炎。糜烂型。由于潮湿．浸渍而使表面发白。瘙痒较重，在湿热条件下工作或生活的人多见。鳞屑角化型。皮肤干燥，粗糙，寒冷季节多发生手足皲裂。