Objective: To study the role of neuropeptide Y (NPY) in the pathogenesis of vitiligo. Methods: The levels of NPY in the plasma from patients with vitiligo and healthy volunteers were measured by 125I RIA Kit. The expr...Objective: To study the role of neuropeptide Y (NPY) in the pathogenesis of vitiligo. Methods: The levels of NPY in the plasma from patients with vitiligo and healthy volunteers were measured by 125I RIA Kit. The expression of NPY in normal skin tissues, uninvolved tissues and lesional tissues of vitiligo was detected by immunohistochemistry. Results: The levels of NPY in the patients with vitiligo of all types were significantly higher than that in the normal controls. In all types, the levels in active stage were significantly higher than those in stable stage. The expression of NPY was upregulated in lesions of patients with active vitiligo (P<0.01) compared with those in normal skin tissues and uninvolved tissues. There was significant difference of NPY expression between active stage and stable stage (P<0.01). Conclusion: These findings support the concept of neuropeptide involvement in vitiligo, especially in active vitiligo, and suggest that NPY may play a role in the pathogenesis of this disease.展开更多
Objective: For the purpose of understanding the changingprocess of syphilis histomorphology and its injury mechanism,the ultrastructure of dermatic tissues of secondary syphiliswas studied. Methods: Different skin inj...Objective: For the purpose of understanding the changingprocess of syphilis histomorphology and its injury mechanism,the ultrastructure of dermatic tissues of secondary syphiliswas studied. Methods: Different skin injury tissues of secondary syphilispatients, whose serum RPR and TPHA tests in the lab bothappeared positive reaction, were observed throughtransmission electron microscope(TEM). Results: Inflammations appeared on epidermides and coria,a great deal of neutrocytes, lymphocytes and a small amountof plasma innltrated them. Karyopyknosis, karyorrhexis,epicyte lysis and mitochondrion vacular degenerationoccurred. Spirocheta pallida was distributed on intercellularsubstances, epicytes and collagenous fibers. The epicytes werepressed to foveation. Conclusion The pathological change ofcharacteristic tissue ultrastructure reported here is ahistomorphological foundation to study the organism injurymechanism caused by syphilis.展开更多
文摘Objective: To study the role of neuropeptide Y (NPY) in the pathogenesis of vitiligo. Methods: The levels of NPY in the plasma from patients with vitiligo and healthy volunteers were measured by 125I RIA Kit. The expression of NPY in normal skin tissues, uninvolved tissues and lesional tissues of vitiligo was detected by immunohistochemistry. Results: The levels of NPY in the patients with vitiligo of all types were significantly higher than that in the normal controls. In all types, the levels in active stage were significantly higher than those in stable stage. The expression of NPY was upregulated in lesions of patients with active vitiligo (P<0.01) compared with those in normal skin tissues and uninvolved tissues. There was significant difference of NPY expression between active stage and stable stage (P<0.01). Conclusion: These findings support the concept of neuropeptide involvement in vitiligo, especially in active vitiligo, and suggest that NPY may play a role in the pathogenesis of this disease.
文摘Objective: For the purpose of understanding the changingprocess of syphilis histomorphology and its injury mechanism,the ultrastructure of dermatic tissues of secondary syphiliswas studied. Methods: Different skin injury tissues of secondary syphilispatients, whose serum RPR and TPHA tests in the lab bothappeared positive reaction, were observed throughtransmission electron microscope(TEM). Results: Inflammations appeared on epidermides and coria,a great deal of neutrocytes, lymphocytes and a small amountof plasma innltrated them. Karyopyknosis, karyorrhexis,epicyte lysis and mitochondrion vacular degenerationoccurred. Spirocheta pallida was distributed on intercellularsubstances, epicytes and collagenous fibers. The epicytes werepressed to foveation. Conclusion The pathological change ofcharacteristic tissue ultrastructure reported here is ahistomorphological foundation to study the organism injurymechanism caused by syphilis.
