目的探讨中医调冲消斑汤治疗对黄褐斑患者全身症状改善情况及皮肤病生活质量指数的影响。方法选取我院2020年5月至2022年12月治疗的60例黄褐斑患者,按数字随机分组法将患者分为研究组和对照组,各30例。对照组采用外用氢醌乳膏联合口服...目的探讨中医调冲消斑汤治疗对黄褐斑患者全身症状改善情况及皮肤病生活质量指数的影响。方法选取我院2020年5月至2022年12月治疗的60例黄褐斑患者,按数字随机分组法将患者分为研究组和对照组,各30例。对照组采用外用氢醌乳膏联合口服氨甲环酸片(妥塞敏)、维生素C治疗,研究组在对照组的基础上加用中医调冲消斑汤治疗。对比两组总有效率和皮损面积、皮损颜色、皮肤病生活质量评分(Dermatology Life Quality Index,DLQI)以及血清雌激素和孕激素水平改善情况。结果研究组黄褐斑患者的总有效率显著高于对照组(P<0.05)。研究组的黄褐斑患者治疗前皮损面积、皮损颜色、DLQI评分和血清雌激素、孕激素水平与对照组治疗前相比无显著差异(P>0.05);干预之后两组黄褐斑患者皮损面积、皮损颜色、DLQI评分和血清雌激素、孕激素水平均显著改善(P<0.05),且研究组黄褐斑患者皮损面积、皮损颜色、DLQI评分和血清雌激素、孕激素水平改善情况显著优于对照组(P<0.05)。结论中医调冲消斑汤治疗方式能有效改善黄褐斑患者全身症状改善情况,并进一步改善患者的皮肤病生活质量指数和患者的激素水平,是一种高效的治疗方式。展开更多
目的评估皮肤病生活质量指数（dermatology life quality index，DLQ1）在寻常性银屑病患者进行临床研究中的临床最小重要差值（minimal clinical important differences，MCID）。方法依托在2个中心进行的临床试验“耳穴贴压加西药局...目的评估皮肤病生活质量指数（dermatology life quality index，DLQ1）在寻常性银屑病患者进行临床研究中的临床最小重要差值（minimal clinical important differences，MCID）。方法依托在2个中心进行的临床试验“耳穴贴压加西药局部用药治疗寻常性银屑病的随机对照研究”（注册号为：ChiCTR—TRC．14004916）进行评估。该研究纳入100例合格病例，随机分成治疗组（51例）采用耳穴叠加得肤宝外用治疗和对照组（49例）单纯采用得肤宝外用治疗。在治疗的0周、4周让患者自行填写DLQI进行生活质量评估，并采用分布法和效标法分别对DLQI的耳穴治疗寻常性银屑病患者中MCID进行估算。结果在这个临床研究中，采用分布法估算的DLQI的MCID波动于0．23—2．58之间，采用效标法估算的MCID值为2．53。结论本研究中DLQI的临床最小重要差异值为2．53，代表患者评分下降2．53时皮损达到好转；使用效标法和分布法评估DLQI的MCID，对临床及量表研究具有重要的参考价值。展开更多
Background: Chronic disease can have physical and psychological effects which affect social functioning. These effects can be better understood from the perspective of parent and child by the use of health-related qua...Background: Chronic disease can have physical and psychological effects which affect social functioning. These effects can be better understood from the perspective of parent and child by the use of health-related quality of life (HRQL) measures. Various HRQL measures are now available, of which generic health measures have been the most widely used. These permit comparison between different diseases and also the normal population. Objectives: To cross-validate a new generic HRQL proxy measure for children, the Children’ s Life Quality Index (CLQI), with an established speciality-specific dermatological questionnaire, the Children’ s Dermatology Life Quality Index (CDLQI), in a group of children with chronic skin diseases. The impairment of HRQL in the same group of children with skin disease was then compared with that associated with other common chronic childhood diseases using the CLQI. Methods: The CDLQI was completed by 379 children aged 5- 16 years with skin disease of more than 6 months’ duration. Their parents (n = 379) and parents of 161 children aged 5- 16 years with other chronic diseases were also asked to complete a proxy measure, the CLQI. Results: Using linear regression analysis, the CLQI and the CDLQI scores showed a strong linear association (rs = 0.72, P < 0.001) and on a Bland-Altman plot, reasonably good agreement (expressing scores out of 100, the 95% limits of agreement were from - 25.5/100 to 26.7/100). In the child’ s opinion psoriasis and atopic dermatitis (AD) caused the greatest impairment (CDLQI scores of 30.6% and 30.5% ), followed by urticaria (20% ) and acne (18% ). Using the generic CLQI (scored 0- 36), from the parental perspective the highest score was for AD (33% ), followed by urticaria (28% ), psoriasis (27% ) and alopecia (19% ). Comparing this with children with other chronic diseases, those with cerebral palsy had the highest score (38% ), followed in descending order by those with generalized AD (33% ), renal disease (33% ), cystic fibrosis (32% ), urticaria (28% ), asthma (28% ) and psoriasis (27% ). Diseases such as epilepsy (24% ) and enuresis (24% ) scored higher than diabetes (19% ), localized eczema (19% ), alopecia (19% ) and acne (16% ). Conclusions: Using the CLQI we have shown that HRQL impairment in children with chronic skin disease is at least equal to that experienced by children with many other chronic diseases of childhood, with AD and psoriasis having the greatest impact on HRQL among chronic skin disorders and only cerebral palsy scoring higher than AD. Cross-validation of the CLQI with the CDLQI in the group of children with skin disease demonstrates a strong linear association and good agreement between the two.展开更多
The objective of this study was to assess the impact of chronic dermatological diseases on quality of life (QoL) of Norwegian patients following in-patient management. QoL was measured by the Norwegian version of the ...The objective of this study was to assess the impact of chronic dermatological diseases on quality of life (QoL) of Norwegian patients following in-patient management. QoL was measured by the Norwegian version of the Dermatology Life Quality Index, a validated, self-administered questionnaire. Adult inpatients with psoriasis and eczema were selected for one year from the dermatological departments in Norway. A total of 212 patients were included, and 126 patients (50% men, 85 with psoriasis and 41 with eczema, mean age 46 years) completed the questionnaires at time of hospital admission and one week after discharge. The patients reported adverse impacton QoL, but no differences between the psoriasis and eczema groups could be demonstrated. Patients with psoriasis improved from 18.3 (7.6) (mean (SD)) to 12.1 (8.2) (p < 0.01), and those with eczema improved from 20.0 (6.0) to 14.4 (7.8) (p < 0.01). Seventy percent of the patients showed improvement, 20% remained unchanged and 10% worsened. The parameters for which the most improvement was seen were those that were of most concern to the patients, i.e. their symptoms and embarrassment. In conclusion, the results are consistent with previous international studies.展开更多
目的:评价男性雄激素性秃发(androgenetic alopecia,AGA)患者生活质量。方法:采用皮肤病生活质量指数(dermatology life quality index,DLQI)量表对165例男性AGA患者生活质量进行评估,并对问卷结果进行信度、效度及相关因素分析。结果:...目的:评价男性雄激素性秃发(androgenetic alopecia,AGA)患者生活质量。方法:采用皮肤病生活质量指数(dermatology life quality index,DLQI)量表对165例男性AGA患者生活质量进行评估,并对问卷结果进行信度、效度及相关因素分析。结果:共调查165例AGA患者,DLQI总分平均为(5.50±4.44)分,该评分在年龄、婚姻及脱发严重程度这3个方面差异有统计学意义。结论:AGA影响了男性患者的生活质量。患者的生活质量与年龄、脱发严重程度及婚姻状态呈负相关。展开更多
文摘目的探讨中医调冲消斑汤治疗对黄褐斑患者全身症状改善情况及皮肤病生活质量指数的影响。方法选取我院2020年5月至2022年12月治疗的60例黄褐斑患者,按数字随机分组法将患者分为研究组和对照组,各30例。对照组采用外用氢醌乳膏联合口服氨甲环酸片(妥塞敏)、维生素C治疗,研究组在对照组的基础上加用中医调冲消斑汤治疗。对比两组总有效率和皮损面积、皮损颜色、皮肤病生活质量评分(Dermatology Life Quality Index,DLQI)以及血清雌激素和孕激素水平改善情况。结果研究组黄褐斑患者的总有效率显著高于对照组(P<0.05)。研究组的黄褐斑患者治疗前皮损面积、皮损颜色、DLQI评分和血清雌激素、孕激素水平与对照组治疗前相比无显著差异(P>0.05);干预之后两组黄褐斑患者皮损面积、皮损颜色、DLQI评分和血清雌激素、孕激素水平均显著改善(P<0.05),且研究组黄褐斑患者皮损面积、皮损颜色、DLQI评分和血清雌激素、孕激素水平改善情况显著优于对照组(P<0.05)。结论中医调冲消斑汤治疗方式能有效改善黄褐斑患者全身症状改善情况,并进一步改善患者的皮肤病生活质量指数和患者的激素水平,是一种高效的治疗方式。
文摘目的评估皮肤病生活质量指数（dermatology life quality index，DLQ1）在寻常性银屑病患者进行临床研究中的临床最小重要差值（minimal clinical important differences，MCID）。方法依托在2个中心进行的临床试验“耳穴贴压加西药局部用药治疗寻常性银屑病的随机对照研究”（注册号为：ChiCTR—TRC．14004916）进行评估。该研究纳入100例合格病例，随机分成治疗组（51例）采用耳穴叠加得肤宝外用治疗和对照组（49例）单纯采用得肤宝外用治疗。在治疗的0周、4周让患者自行填写DLQI进行生活质量评估，并采用分布法和效标法分别对DLQI的耳穴治疗寻常性银屑病患者中MCID进行估算。结果在这个临床研究中，采用分布法估算的DLQI的MCID波动于0．23—2．58之间，采用效标法估算的MCID值为2．53。结论本研究中DLQI的临床最小重要差异值为2．53，代表患者评分下降2．53时皮损达到好转；使用效标法和分布法评估DLQI的MCID，对临床及量表研究具有重要的参考价值。
文摘Background: Chronic disease can have physical and psychological effects which affect social functioning. These effects can be better understood from the perspective of parent and child by the use of health-related quality of life (HRQL) measures. Various HRQL measures are now available, of which generic health measures have been the most widely used. These permit comparison between different diseases and also the normal population. Objectives: To cross-validate a new generic HRQL proxy measure for children, the Children’ s Life Quality Index (CLQI), with an established speciality-specific dermatological questionnaire, the Children’ s Dermatology Life Quality Index (CDLQI), in a group of children with chronic skin diseases. The impairment of HRQL in the same group of children with skin disease was then compared with that associated with other common chronic childhood diseases using the CLQI. Methods: The CDLQI was completed by 379 children aged 5- 16 years with skin disease of more than 6 months’ duration. Their parents (n = 379) and parents of 161 children aged 5- 16 years with other chronic diseases were also asked to complete a proxy measure, the CLQI. Results: Using linear regression analysis, the CLQI and the CDLQI scores showed a strong linear association (rs = 0.72, P < 0.001) and on a Bland-Altman plot, reasonably good agreement (expressing scores out of 100, the 95% limits of agreement were from - 25.5/100 to 26.7/100). In the child’ s opinion psoriasis and atopic dermatitis (AD) caused the greatest impairment (CDLQI scores of 30.6% and 30.5% ), followed by urticaria (20% ) and acne (18% ). Using the generic CLQI (scored 0- 36), from the parental perspective the highest score was for AD (33% ), followed by urticaria (28% ), psoriasis (27% ) and alopecia (19% ). Comparing this with children with other chronic diseases, those with cerebral palsy had the highest score (38% ), followed in descending order by those with generalized AD (33% ), renal disease (33% ), cystic fibrosis (32% ), urticaria (28% ), asthma (28% ) and psoriasis (27% ). Diseases such as epilepsy (24% ) and enuresis (24% ) scored higher than diabetes (19% ), localized eczema (19% ), alopecia (19% ) and acne (16% ). Conclusions: Using the CLQI we have shown that HRQL impairment in children with chronic skin disease is at least equal to that experienced by children with many other chronic diseases of childhood, with AD and psoriasis having the greatest impact on HRQL among chronic skin disorders and only cerebral palsy scoring higher than AD. Cross-validation of the CLQI with the CDLQI in the group of children with skin disease demonstrates a strong linear association and good agreement between the two.
文摘The objective of this study was to assess the impact of chronic dermatological diseases on quality of life (QoL) of Norwegian patients following in-patient management. QoL was measured by the Norwegian version of the Dermatology Life Quality Index, a validated, self-administered questionnaire. Adult inpatients with psoriasis and eczema were selected for one year from the dermatological departments in Norway. A total of 212 patients were included, and 126 patients (50% men, 85 with psoriasis and 41 with eczema, mean age 46 years) completed the questionnaires at time of hospital admission and one week after discharge. The patients reported adverse impacton QoL, but no differences between the psoriasis and eczema groups could be demonstrated. Patients with psoriasis improved from 18.3 (7.6) (mean (SD)) to 12.1 (8.2) (p < 0.01), and those with eczema improved from 20.0 (6.0) to 14.4 (7.8) (p < 0.01). Seventy percent of the patients showed improvement, 20% remained unchanged and 10% worsened. The parameters for which the most improvement was seen were those that were of most concern to the patients, i.e. their symptoms and embarrassment. In conclusion, the results are consistent with previous international studies.
文摘目的:评价男性雄激素性秃发(androgenetic alopecia,AGA)患者生活质量。方法:采用皮肤病生活质量指数(dermatology life quality index,DLQI)量表对165例男性AGA患者生活质量进行评估,并对问卷结果进行信度、效度及相关因素分析。结果:共调查165例AGA患者,DLQI总分平均为(5.50±4.44)分,该评分在年龄、婚姻及脱发严重程度这3个方面差异有统计学意义。结论:AGA影响了男性患者的生活质量。患者的生活质量与年龄、脱发严重程度及婚姻状态呈负相关。
