In patients with chronic lymphocytic leukemia, squamous cell carcinoma behaves aggressively. Our purpose was to compare squamous cell carcinoma metastasis and mortality between patients with chronic lymphocytic leukem...In patients with chronic lymphocytic leukemia, squamous cell carcinoma behaves aggressively. Our purpose was to compare squamous cell carcinoma metastasis and mortality between patients with chronic lymphocytic leukemia and control subjects. Medical records were assessed retrospectively for 28 patients with chronic lymphocytic leukemia who underwent surgical excision of cutaneous squamous cell carcinoma and for 56 matched control subjects. The rate of metastasis and mortality from cutaneous squamous cell carcinoma were determined on a per-patient basis. Three of 28 patients with chronic lymphocytic leukemia had metastasis and died of metastatic disease. No metastases or deaths occurred among the 56 control subjects. Comparedwith control subjects, chronic lymphocytic leukemia patients with cutaneous squamous cell carcinoma were more likely to have metastasis (P = .0031) and die of metastasis (P = .0033). No significant association was detected between metastasis and history of chemotherapy administration for chronic lymphocytic leukemia. Among patients with chronic lymphocytic leukemia, surveillance for skin cancer and a decreased threshold for biopsy of suspect lesions are warranted.展开更多
Purpose To report an unusual bilateral ulcerative lid in-volvement as the presenting manifestation of a severe Crohn disease.Design Observational case report.Method De-scription of an otherwise healthy wo man who init...Purpose To report an unusual bilateral ulcerative lid in-volvement as the presenting manifestation of a severe Crohn disease.Design Observational case report.Method De-scription of an otherwise healthy wo man who initially pre-sented with bilateral ulcerative li d involvement before the discovery of an extensive ulcerativ e intestinal inflammatory disease.Results A 32-year old woman presented with bi-lateral ulcerative blepharitis.Sh e also complained of aph-thous oral lesions and diarrheic epi sodes for the previous 3days.Impression cytology of the lid ulcers showed con-junctival cells,together with the p resence of lymphocytes and macrophages.Colonoscopy and colonic biopsy were characteristic of Crohn disease.The treatment with sys-temic corticosteroids healed bowel,oral,and lidmargin ulcerative lesions.Conclusion The simultaneous appear-ance of ulcerative lesions in the int estinal mucosa and in the mucocutaneous lid margin and the comparable features encountered in the cytologic studie s indicate that ulcerativelid margin disease could be an ocular manifestations of Crohn disease.展开更多
文摘In patients with chronic lymphocytic leukemia, squamous cell carcinoma behaves aggressively. Our purpose was to compare squamous cell carcinoma metastasis and mortality between patients with chronic lymphocytic leukemia and control subjects. Medical records were assessed retrospectively for 28 patients with chronic lymphocytic leukemia who underwent surgical excision of cutaneous squamous cell carcinoma and for 56 matched control subjects. The rate of metastasis and mortality from cutaneous squamous cell carcinoma were determined on a per-patient basis. Three of 28 patients with chronic lymphocytic leukemia had metastasis and died of metastatic disease. No metastases or deaths occurred among the 56 control subjects. Comparedwith control subjects, chronic lymphocytic leukemia patients with cutaneous squamous cell carcinoma were more likely to have metastasis (P = .0031) and die of metastasis (P = .0033). No significant association was detected between metastasis and history of chemotherapy administration for chronic lymphocytic leukemia. Among patients with chronic lymphocytic leukemia, surveillance for skin cancer and a decreased threshold for biopsy of suspect lesions are warranted.
文摘Purpose To report an unusual bilateral ulcerative lid in-volvement as the presenting manifestation of a severe Crohn disease.Design Observational case report.Method De-scription of an otherwise healthy wo man who initially pre-sented with bilateral ulcerative li d involvement before the discovery of an extensive ulcerativ e intestinal inflammatory disease.Results A 32-year old woman presented with bi-lateral ulcerative blepharitis.Sh e also complained of aph-thous oral lesions and diarrheic epi sodes for the previous 3days.Impression cytology of the lid ulcers showed con-junctival cells,together with the p resence of lymphocytes and macrophages.Colonoscopy and colonic biopsy were characteristic of Crohn disease.The treatment with sys-temic corticosteroids healed bowel,oral,and lidmargin ulcerative lesions.Conclusion The simultaneous appear-ance of ulcerative lesions in the int estinal mucosa and in the mucocutaneous lid margin and the comparable features encountered in the cytologic studie s indicate that ulcerativelid margin disease could be an ocular manifestations of Crohn disease.
