Background. The pathogenesis of post- kala-azar dermal leishmaniasis (PKDL) is ill understood.This study was carried out to find the percentage of T- helper and T-suppressor cells in lesional tissue and their probable...Background. The pathogenesis of post- kala-azar dermal leishmaniasis (PKDL) is ill understood.This study was carried out to find the percentage of T- helper and T-suppressor cells in lesional tissue and their probable role in the pathogenesis of PKDL. Methods. An immunoperoxidase monoclonal antibody technique was used to characterize and quantify the subsets of T lymphocytes in the infiltrate in 25 patients with PKDL. Results. The ratio of T-helper to T- suppressor cells was 0.87 in hypopigmented macules and 0.85 in nodule and/or plaque lesions of PKDL. Conclusions. In this study, there was a definite preponderance of T-suppressor cells over T-helper cells in both types of skin lesions of PKDL. Further studies should be undertaken on larger numbers of patients to compare T- cell subsets both in skin lesions and the circulation, in order to determine the pathogenesis of PKDL.展开更多
025 秘鲁圣帕伯罗的联合化疗 Carmen M et al Revista de Lepr,1989,17(3):251(西班牙文) 在秘鲁这所古老的麻风病院中过去单用DDS的病人改用联合化疗(WHO,1982),开始时很难,因为多数病人认为他们的病是治不好的。后来证明效果良好,接...025 秘鲁圣帕伯罗的联合化疗 Carmen M et al Revista de Lepr,1989,17(3):251(西班牙文) 在秘鲁这所古老的麻风病院中过去单用DDS的病人改用联合化疗(WHO,1982),开始时很难,因为多数病人认为他们的病是治不好的。后来证明效果良好,接着凡新病人都能按时服药。展开更多
文摘Background. The pathogenesis of post- kala-azar dermal leishmaniasis (PKDL) is ill understood.This study was carried out to find the percentage of T- helper and T-suppressor cells in lesional tissue and their probable role in the pathogenesis of PKDL. Methods. An immunoperoxidase monoclonal antibody technique was used to characterize and quantify the subsets of T lymphocytes in the infiltrate in 25 patients with PKDL. Results. The ratio of T-helper to T- suppressor cells was 0.87 in hypopigmented macules and 0.85 in nodule and/or plaque lesions of PKDL. Conclusions. In this study, there was a definite preponderance of T-suppressor cells over T-helper cells in both types of skin lesions of PKDL. Further studies should be undertaken on larger numbers of patients to compare T- cell subsets both in skin lesions and the circulation, in order to determine the pathogenesis of PKDL.
文摘025 秘鲁圣帕伯罗的联合化疗 Carmen M et al Revista de Lepr,1989,17(3):251(西班牙文) 在秘鲁这所古老的麻风病院中过去单用DDS的病人改用联合化疗(WHO,1982),开始时很难,因为多数病人认为他们的病是治不好的。后来证明效果良好,接着凡新病人都能按时服药。
