Approximately 25%of patients with idiopathic Parkinsons disease (IPD) later develop dementia, with the typical characteristics as detailed in ICD 10 and D SM IV. Differential diagnosis has to exclude dementia due to...Approximately 25%of patients with idiopathic Parkinsons disease (IPD) later develop dementia, with the typical characteristics as detailed in ICD 10 and D SM IV. Differential diagnosis has to exclude dementia due to Lewy bodies, subco rtical vascular encephalopathy and subcortical dementia due to progressive supra nuclear paralysis or corticobasal degeneration. Several studies showed promising results for cholinesterase inhibitors such as donepezile, rivastigmine and gala ntamine. The demented Parkinsonian patients then present with improvement in cog nitive function while motor skills do not deteriorate.展开更多
文摘Approximately 25%of patients with idiopathic Parkinsons disease (IPD) later develop dementia, with the typical characteristics as detailed in ICD 10 and D SM IV. Differential diagnosis has to exclude dementia due to Lewy bodies, subco rtical vascular encephalopathy and subcortical dementia due to progressive supra nuclear paralysis or corticobasal degeneration. Several studies showed promising results for cholinesterase inhibitors such as donepezile, rivastigmine and gala ntamine. The demented Parkinsonian patients then present with improvement in cog nitive function while motor skills do not deteriorate.
