To observe the therapeutic effect of Yikang Tang(益抗汤 Yikang Decoction)for male immuneinfertility.Methods:100 cases of male immune infertility in the treatment group were treated withYikang Decoction,while 100 cases...To observe the therapeutic effect of Yikang Tang(益抗汤 Yikang Decoction)for male immuneinfertility.Methods:100 cases of male immune infertility in the treatment group were treated withYikang Decoction,while 100 cases treated with prednisone as the controls.Physical exam,routine semenand prostate exams,and exams for presence of anti-sperm antibody(AsAb)and mycoplasma in the serum orseminal plasma were carried out.Results:1)The serum and seminal plasma AsAb levels decreasedsignificantly(P<0.01)in both the groups after treatment,with a more remarkable effect in the treatmentgroup.2)The sperm density and percentage of motile spermatozoa increased significantly in the two groups,but more significantly in the treatment group after treatment.The pregnancy rate of their wives was higher inthe treatment group than that in the control group(P<0.01).3)The sperm agglutination rate in the twogroups decreased,but more significantly in the treatment group after treatment.4)The improvement rate ofthe symptoms and the stability of the therapeutic effect were more dramatic in the treatment group than thatin the control group(P<0.01)after termination of drug administration.Conclusion:The YikangDecoction has a more stable effect for male immune infertility than prednisone.展开更多
胃癌发病率和病死率逐年上升,胃癌前病变(precancerous lesions of gastric cancer,PLGC)是正常胃黏膜转化成胃癌的重要过程。益胃抗癌汤为王新杰教授自拟方,通过多年临床运用发现其在改善胃黏膜功能,延缓胃癌进程方面疗效显著,文章基...胃癌发病率和病死率逐年上升,胃癌前病变(precancerous lesions of gastric cancer,PLGC)是正常胃黏膜转化成胃癌的重要过程。益胃抗癌汤为王新杰教授自拟方,通过多年临床运用发现其在改善胃黏膜功能,延缓胃癌进程方面疗效显著,文章基于网络药理学方法探讨益胃抗癌汤治疗胃癌前病变的分子机制,获得益胃抗癌汤1889个活性成分和499个潜在治疗靶点,通过GeneCards得到胃癌前病变1612个相关靶点,交集靶点168个,从PPI核心网络筛选出71个关键靶点,GO和KEGG分析相关靶基因,参与了4870个生物学反应过程、447个细胞功能、329个细胞组分以及345个相关信号通路,通过分子对接,所有核心靶基因与核心成分均具有较好的结合活性,其中对接分数较高的是小檗碱、非洲防己碱和氢化小檗碱。为临床应用和进一步的实验验证提供参考。展开更多
文摘To observe the therapeutic effect of Yikang Tang(益抗汤 Yikang Decoction)for male immuneinfertility.Methods:100 cases of male immune infertility in the treatment group were treated withYikang Decoction,while 100 cases treated with prednisone as the controls.Physical exam,routine semenand prostate exams,and exams for presence of anti-sperm antibody(AsAb)and mycoplasma in the serum orseminal plasma were carried out.Results:1)The serum and seminal plasma AsAb levels decreasedsignificantly(P<0.01)in both the groups after treatment,with a more remarkable effect in the treatmentgroup.2)The sperm density and percentage of motile spermatozoa increased significantly in the two groups,but more significantly in the treatment group after treatment.The pregnancy rate of their wives was higher inthe treatment group than that in the control group(P<0.01).3)The sperm agglutination rate in the twogroups decreased,but more significantly in the treatment group after treatment.4)The improvement rate ofthe symptoms and the stability of the therapeutic effect were more dramatic in the treatment group than thatin the control group(P<0.01)after termination of drug administration.Conclusion:The YikangDecoction has a more stable effect for male immune infertility than prednisone.
文摘胃癌发病率和病死率逐年上升,胃癌前病变(precancerous lesions of gastric cancer,PLGC)是正常胃黏膜转化成胃癌的重要过程。益胃抗癌汤为王新杰教授自拟方,通过多年临床运用发现其在改善胃黏膜功能,延缓胃癌进程方面疗效显著,文章基于网络药理学方法探讨益胃抗癌汤治疗胃癌前病变的分子机制,获得益胃抗癌汤1889个活性成分和499个潜在治疗靶点,通过GeneCards得到胃癌前病变1612个相关靶点,交集靶点168个,从PPI核心网络筛选出71个关键靶点,GO和KEGG分析相关靶基因,参与了4870个生物学反应过程、447个细胞功能、329个细胞组分以及345个相关信号通路,通过分子对接,所有核心靶基因与核心成分均具有较好的结合活性,其中对接分数较高的是小檗碱、非洲防己碱和氢化小檗碱。为临床应用和进一步的实验验证提供参考。
