目的:探讨“益气清湿化瘀”法对慢性子宫内膜炎性不孕的疗效。方法:于2022年12月至2023年12月期间共纳入患者132例,其中来源于成都中医药大学附属医院60例,四川省第二中医医院36例,四川省人民医院温江医院36例,将以上患者随机按数字表法...目的:探讨“益气清湿化瘀”法对慢性子宫内膜炎性不孕的疗效。方法:于2022年12月至2023年12月期间共纳入患者132例,其中来源于成都中医药大学附属医院60例,四川省第二中医医院36例,四川省人民医院温江医院36例,将以上患者随机按数字表法以1:1分为对照组和观察组各66例。治疗组口服自拟盆炎康复汤、妇科灌肠液直肠给药联合口服盐酸多西环素,对照组口服妇科千金胶囊和盐酸多西环素,两组均治疗3个月,并随访半年。治疗结束后采用多模态超声评价患者子宫内膜容受性,并记录其治疗前后中医证候评分变化及月经改变,同时随访患者妊娠率及早期流产情况。结果:治疗组临床妊娠率29.03%,妊娠率38.70%,均高于对照组的13.11%与21.31% (P 0.05);治疗后治疗组的子宫内膜容受性的超声检查评分明显高于对照组;治疗组中医症候评分低于对照组(P Objective: To explore the efficacy of “supplementing qi, clearing dampness and removing stasis” on chronic endometritis infertility. Methods: From December 2022 to December 2023, a total of 132 patients were included, including 60 from the Hospital of Chengdu University of Traditional Chinese Medicine, 36 from the Second Hospital of Traditional Chinese Medicine of Sichuan Province, and 36 from Chengdu Wenjiang Hospital of Sichuan Provincial People’s Hospital. The above patients were randomly divided by 1:1 into the control group and 66 from the observation group according to the number table method. The treatment group received oral self-prepared pelvic inflammation rehabilitation soup, gynecological enema and rectal administration combined with oral doxycycline hydrochloride, and the control group took oral gynecological Qianjin capsule and doxycycline hydrochloride. Both groups were treated for 3 months and followed up for half a year. After the end of treatment, multimodal ultrasound was used to evaluate endometrial tolerance, and the changes of TCM syndrome score and menstrual changes before and after treatment were recorded, and the pregnancy rate and early abortion were followed up. Results: The clinical pregnancy rate in the treatment group was 29.03%, The pregnancy rate was 38.70%, Are higher than the control group of 13.11% % and 21.31% (P 0.05);the ultrasound score of endometrial receptivity in the treated group was significantly higher than that of the control group;TCM syndrome score in the treatment group than the control group (P < 0.05);the recovery rate of menstrual abnormalities, abnormal leucorrhea and pelvic pain after treatment was higher than the control group, statistically significant (P < 0.05). Conclusion: “Self-prepared pelvic inflammation rehabilitation soup, gynecological enema combined with doxycycline hydrochloride” is effective in improving endometrial receptivity of chronic endometritis infertility patients, regulating patients’ menstruation, improving TCM syndrome, and promoting fertility, which is worthy of gynecological clinical promotion and application.展开更多
文摘目的:探讨“益气清湿化瘀”法对慢性子宫内膜炎性不孕的疗效。方法:于2022年12月至2023年12月期间共纳入患者132例,其中来源于成都中医药大学附属医院60例,四川省第二中医医院36例,四川省人民医院温江医院36例,将以上患者随机按数字表法以1:1分为对照组和观察组各66例。治疗组口服自拟盆炎康复汤、妇科灌肠液直肠给药联合口服盐酸多西环素,对照组口服妇科千金胶囊和盐酸多西环素,两组均治疗3个月,并随访半年。治疗结束后采用多模态超声评价患者子宫内膜容受性,并记录其治疗前后中医证候评分变化及月经改变,同时随访患者妊娠率及早期流产情况。结果:治疗组临床妊娠率29.03%,妊娠率38.70%,均高于对照组的13.11%与21.31% (P 0.05);治疗后治疗组的子宫内膜容受性的超声检查评分明显高于对照组;治疗组中医症候评分低于对照组(P Objective: To explore the efficacy of “supplementing qi, clearing dampness and removing stasis” on chronic endometritis infertility. Methods: From December 2022 to December 2023, a total of 132 patients were included, including 60 from the Hospital of Chengdu University of Traditional Chinese Medicine, 36 from the Second Hospital of Traditional Chinese Medicine of Sichuan Province, and 36 from Chengdu Wenjiang Hospital of Sichuan Provincial People’s Hospital. The above patients were randomly divided by 1:1 into the control group and 66 from the observation group according to the number table method. The treatment group received oral self-prepared pelvic inflammation rehabilitation soup, gynecological enema and rectal administration combined with oral doxycycline hydrochloride, and the control group took oral gynecological Qianjin capsule and doxycycline hydrochloride. Both groups were treated for 3 months and followed up for half a year. After the end of treatment, multimodal ultrasound was used to evaluate endometrial tolerance, and the changes of TCM syndrome score and menstrual changes before and after treatment were recorded, and the pregnancy rate and early abortion were followed up. Results: The clinical pregnancy rate in the treatment group was 29.03%, The pregnancy rate was 38.70%, Are higher than the control group of 13.11% % and 21.31% (P 0.05);the ultrasound score of endometrial receptivity in the treated group was significantly higher than that of the control group;TCM syndrome score in the treatment group than the control group (P < 0.05);the recovery rate of menstrual abnormalities, abnormal leucorrhea and pelvic pain after treatment was higher than the control group, statistically significant (P < 0.05). Conclusion: “Self-prepared pelvic inflammation rehabilitation soup, gynecological enema combined with doxycycline hydrochloride” is effective in improving endometrial receptivity of chronic endometritis infertility patients, regulating patients’ menstruation, improving TCM syndrome, and promoting fertility, which is worthy of gynecological clinical promotion and application.
