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SPE-HPLC法测定强力枇杷露中盐酸可待因 被引量:2
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作者 巩晓宇 陆燕萍 邱凤邹 《药物评价研究》 CAS 2017年第5期672-674,共3页
目的建立反相高效液相色谱测定强力枇杷露中磷酸可待因的方法。方法采用Eclipse XDB-C_(18)柱(250 mm×4.6mm,5μm),乙腈-0.035 mol/L醋酸钠溶液(冰醋酸调pH=3.5)(25∶75)为流动相,体积流量为1.0 mL/min,检测波长为240 nm,柱温为40... 目的建立反相高效液相色谱测定强力枇杷露中磷酸可待因的方法。方法采用Eclipse XDB-C_(18)柱(250 mm×4.6mm,5μm),乙腈-0.035 mol/L醋酸钠溶液(冰醋酸调pH=3.5)(25∶75)为流动相,体积流量为1.0 mL/min,检测波长为240 nm,柱温为40℃。结果磷酸可待因在2.024~40.24μg/mL线性良好,回归方程为y=8.18×10~5x+12.2(r=0.999 2);平均加样回收率为98.2%,RSD为1.0%(n=6)。结论该方法快速准确,灵敏度高,用于强力枇杷露中盐酸可待因含量测定,控制药品质量。 展开更多
关键词 强力枇杷露 盐酸可待因 固相萃取 高效液相色谱法
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Double-blinded, Controlled, Randomized Study of Dihydrocodeine Tartrate vs Codeine Phosphate in Treating Cancer Pain
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作者 王杰军 邹建军 +5 位作者 高勇 许青 曹传武 钱建新 许德凤 潘慧君 《The Chinese-German Journal of Clinical Oncology》 CAS 2005年第2期108-111,共4页
To compare the effects and adverse reactions of dihydrocodeine tartrate andcodeine phosphate in treating moderate cancer pain. Methods: Sixty-nine cases of cancer patientswith moderate pain were treated with dihydroco... To compare the effects and adverse reactions of dihydrocodeine tartrate andcodeine phosphate in treating moderate cancer pain. Methods: Sixty-nine cases of cancer patientswith moderate pain were treated with dihydrocodeine tartrate or codeine phosphate respectively bydouble-blind, controlled randomized methods and the effects and adverse reactions were observed.Results: After administration of dihydrocodeine tartrate or codeine phosphate, in treatment group orcontrol group, the total effective rate was 86.6% and 93.6%, and common adverse symptoms includedconstipation (31.3%/12.9%), nausea (18.8%/19.7%), gastric trouble (18.8%/19.7%), skin pruritus(12.5%/10%), vomit (9.3% and 6.5%) with the difference being not significant. Conclusion: Theeffects of dihydrocodeine tartrate in treating moderate cancer pain are similar to codeinephosphate. Both them can be used to treat moderate cancer pain. 展开更多
关键词 dihydrocodeine tartrate codeine phosphate cancer pain
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