Aim To develop a method to estimate population pharmacokinetic parameters with the limited sampling time points provided clinically during therapeutic drug monitoring. Methods Various simulations were attempted using ...Aim To develop a method to estimate population pharmacokinetic parameters with the limited sampling time points provided clinically during therapeutic drug monitoring. Methods Various simulations were attempted using a one-compartment open model with the first order absorption to determine PK parameter estimates with different sampling strategies as a validation of the method. The estimated parameters were further verified by comparing to the observed values. Results The samples collected at the single time point close to the non-informative sampling time point designed by this method led to bias and inaccurate parameter estimations. Furthermore, the relationship between the estimated non-informative sampling time points and the values of the parameter was examined. The non-informative sampling time points have been developed under some typical occasions and the results were plotted to show the tendency. As a result, one non-informative time point was demonstrated to be appropriate for clearance and two for both volume of distribution and constant of absorption in the present study. It was found that the estimates of the non-informative sampling time points developed in the method increase with increases of volume of distribution and the decrease of clearance and constant of absorption. Conclusion A rational sampling strategy during therapeutic drug monitoring can be established using the method present in the study.展开更多
The energy efficiency monitoring is an essential precondition for ground source heat pump system's controlling and energy saving operation. Based on the data monitoring applied in the school building, this work is...The energy efficiency monitoring is an essential precondition for ground source heat pump system's controlling and energy saving operation. Based on the data monitoring applied in the school building, this work is focused on the parameters acquisition and operation analysis of the GSHP system in Tangshan. Results show the average COPs(coefficient of performance) are2.85 and 2.70 in summer and winter, respectively, and heat(cold) unbalance underground existed after whole year operation. The analysis of data also indicates that the direct borehole air-conditioning saved some power consumption obviously in the early stage of summer and energy saving of the GSHP system depended remarkably on its operation and management level. Besides the observation points of ground temperature are laid for a large-scale GSHP system, and the hydraulic balance of the pipes group needs to be concerned specially in safeguarding better reliability.展开更多
The development and application of the ''digital mine'' concept in China depends heavily upon the use of remote sensing data as well as domestic expertise and awareness. Illegal mining of mineral resou...The development and application of the ''digital mine'' concept in China depends heavily upon the use of remote sensing data as well as domestic expertise and awareness. Illegal mining of mineral resources has been a serious long term problem frustrating the Xishimen Iron Ore Mine management. This mine is located in Wu'an county in Hebei province, China. Illegal activities have led to enormous economic losses by interfering with the normal operation of the Xishimen mine and have ruined the surrounding environ- ment and the stability of the Mahe riverbed the crosses the mined area. This paper is based on field recon- naissance taken over many years around the mine area. The ground survey data are integrated with Differential Synthetic Aperture Radar Interferometry (D-InSAR) results from ALOS/PALSAR data to pin- point mining locations. By investigating the relationship between the resulting interferometric deforma- tion pattern and the mining schedule, which is known a priori, areas affected by illegal mining activities are identified. To some extent these areas indicate the location of the illegal site. The results clearly dem- onstrate D-InSAR's ability to cost-effectively monitor illegal mining activities.展开更多
Agricultural landscapes are essential for the conservation of biodiversity. Nevertheless, a negative trend continues to be observed in many rural areas for the most prominent indicator species group, the farmland bird...Agricultural landscapes are essential for the conservation of biodiversity. Nevertheless, a negative trend continues to be observed in many rural areas for the most prominent indicator species group, the farmland birds. However, clear cause-effect relationships are rarely reported and sometimes difficult to deduce, especially from monitoring data which are based only on the detection of species and counts of the numbers of individuals. Because the identification of habitat preferences is a precondition for farmland bird biodiversity conservation efforts, a monitoring scheme for the simultaneous collection and analysis of bird and land use data was developed and tested. In order to assign the occurrence of bird species to land characteristics at various spatial scales and different land use and crop types, we applied a hierarchical structured sampling design. The spatial scales were ‘agricultural landscape', ‘agricultural landscape types', ‘field crops and other habitats' and ‘vegetation structures'. These scales were integrated with a novel concept, the ‘habitat matrix'(HM). This method was applied to farmland breeding bird abundances on 29 plots, each 1 km2 in size, by the use of the territory mapping method. The same plots were enlarged by a 100 m buffer and the sizes and location of habitats documented. Vegetation height, coverage and density were also recorded for all crop fields in the study area. We propose that this monitoring method facilitates the identification of scale dependent relationships between farmland bird habitat characteristics and bird abundance. This is demonstrated by the farmland bird species Corn Bunting(Emberiza calandra), Skylark(Alauda arvensis), and Whinchat(Saxicola rubetra). The breeding territories of these species reveal large differences within the various spatial scales ‘agricultural landscape', ‘agricultural landscape types' and ‘field crops'. Throughout the breeding season the abundances varied, dependent on the field crop and the development of vegetation structures(height, coverage, and density). HM-analysis led to the identification of specific habitat configurations preferred by individual bird species within the agricultural landscape. These findings indicate that the methodology has the potential to design monitoring schemes for the identification of cause-and-effects of landscape configuration, land use and land use changes on the habitat suitability and abundance of farmland birds.展开更多
Horizontal section top-coal(HSTCC)caving offers a powerful method to efficiently excavate rude coal in steep and thick seams,and pre-blasting weakening has a profound effect on pursuing great production,high efficienc...Horizontal section top-coal(HSTCC)caving offers a powerful method to efficiently excavate rude coal in steep and thick seams,and pre-blasting weakening has a profound effect on pursuing great production,high efficiency and good benefit under particular conditions like a small-scale working face with large-scale sectional caving height.+564-level HSTCC working face in B3–6coal seams of Jiangou Colliery in Urumqi was taken as study case for in situ industrial experiment.Total thickness of seams in the study case is about 50.0 m and average angel here is over 83°.In the industrial experiments,at first we adopted continuous charge machine and emulsion matrix explosive to substitute for traditional blasting schemes for specific geological settings in the study case.Hybrid analyses and assessments with blasting crack propagation analysis,abutment pressure monitoring prediction and economical benefit assessment were attributed to be able to attest pre-blasting weakening effects practically.Meanwhile crack propagation analysis after pre-blasting weakening showed that in all triple monitoring bore holes rock masses of top-coal would be fallen into three stages from the bottom up:fracture zone,plastic zone and elastic zone generally,and fracture toughness respectively in correspondent zones was calculated by the analytical formula:0.5616–0.8806,0.6403–0.9541 and0.7535–1.1900 MPa m1/2after pre-blasting weakening.Pressure monitoring prediction and economical benefit assessment also indicated that it was necessary to introduce the pre-blasting weakening with predominant blasting scheme from both views.For excavation in extremely steep and thick coal seams,relevant results would be a useful tool to study the mechanism of pre-blasting weakening both qualitatively and quantitatively.展开更多
Interact traffic classification is vital to the areas of network operation and management. Traditional classification methods such as port mapping and payload analysis are becoming increasingly difficult as newly emer...Interact traffic classification is vital to the areas of network operation and management. Traditional classification methods such as port mapping and payload analysis are becoming increasingly difficult as newly emerged applications (e. g. Peer-to-Peer) using dynamic port numbers, masquerading techniques and encryption to avoid detection. This paper presents a machine learning (ML) based traffic classifica- tion scheme, which offers solutions to a variety of network activities and provides a platform of performance evaluation for the classifiers. The impact of dataset size, feature selection, number of application types and ML algorithm selection on classification performance is analyzed and demonstrated by the following experiments: (1) The genetic algorithm based feature selection can dramatically reduce the cost without diminishing classification accuracy. (2) The chosen ML algorithms can achieve high classification accuracy. Particularly, REPTree and C4.5 outperform the other ML algorithms when computational complexity and accuracy are both taken into account. (3) Larger dataset and fewer application types would result in better classification accuracy. Finally, early detection with only several initial packets is proposed for real-time network activity and it is proved to be feasible according to the preliminary results.展开更多
Starting from the important role of "Taobao village" in the economic development, the thesis analysed the subjective and objective reasons and promoting group and draw the general process of urbanization. It discuss...Starting from the important role of "Taobao village" in the economic development, the thesis analysed the subjective and objective reasons and promoting group and draw the general process of urbanization. It discussed the different characteristics of "Taobao village" in different economic areas and roles played in urbanizing. It also propounded some constructive suggestion to activate the industry, including strengthening industry supervision, adjusting development patterns, and emphasizing innovation. The paper consists of literature analysis, case analysis and comparative analysis to complement the demonstration.展开更多
Esophageal cancer is mainly found in Asia and east Africa and is one of the deadliest cancers in the world.However,it has not garnered much attention in the Western world due to its low incidence rate.An increasing am...Esophageal cancer is mainly found in Asia and east Africa and is one of the deadliest cancers in the world.However,it has not garnered much attention in the Western world due to its low incidence rate.An increasing amount of data indicate that esophageal cancer,particularly esophageal adenocarcinoma,has been rising by 6-fold annually and is now becoming the fastest growing cancer in the United States.This rise has been associated with the increase of the obese population,as abdominal fat puts extra pressure on the stomach and causes gastroesophageal reflux disease(GERD).Long standing GERD can induce esophagitis and metaplasia and,ultimately,leads to adenocarcinoma.Acid suppression has been the main strategy to treat GERD;however,it has not been proven to control esophageal malignancy effectively.In fact,its side effects have triggered multiple warnings from regulatory agencies.The high mortality and fast growth of esophageal cancer demand more vigorous efforts to look into its deeper mechanisms and come up with better therapeutic options.展开更多
Nowadays, information technology (IT) has become a part of the working culture and environment in many organizations. Originally, it is not a supportive tool to make any business successful, but it have become the b...Nowadays, information technology (IT) has become a part of the working culture and environment in many organizations. Originally, it is not a supportive tool to make any business successful, but it have become the backbone of successful business recently. Any non-IT organization could become dead and non-productive. When time comes, maybe it will fail in the business market. However, the usage of IT instruments must be carried out in good and conducive environment especially for business market. In this study, a basic and practical management about how to manage IT asset in small organizations will be discussed. Then this kind of management will be further discussed when the company become small medium organization. The implementation of IT infrastructure, the requirements, infrastructures, services, and platform from software to hardware and networking devices needs to be known. However, this study focuses on networking infrastructure such as networking equipments, servers, network monitoring software, costing, and management best practices.展开更多
Based on the analysis of different requirements of energy management center construction and the data acquisition of various industries in wide area network, as well as the practices of real-lime online system, the pa...Based on the analysis of different requirements of energy management center construction and the data acquisition of various industries in wide area network, as well as the practices of real-lime online system, the paper puts forward the construction scheme of regional energy management center (REMC) which can achieve real time online monitoring of organizations' energy consumption via data collection, and also proposes the design idea of energy data acquisition based on national standards.展开更多
基金National Natural Science Foundation of China(Grant No. 30472165) the 985 Projects of the State KeyLaboratory of Natural and Biomimetic Drugs (Grant No.268705077280).
文摘Aim To develop a method to estimate population pharmacokinetic parameters with the limited sampling time points provided clinically during therapeutic drug monitoring. Methods Various simulations were attempted using a one-compartment open model with the first order absorption to determine PK parameter estimates with different sampling strategies as a validation of the method. The estimated parameters were further verified by comparing to the observed values. Results The samples collected at the single time point close to the non-informative sampling time point designed by this method led to bias and inaccurate parameter estimations. Furthermore, the relationship between the estimated non-informative sampling time points and the values of the parameter was examined. The non-informative sampling time points have been developed under some typical occasions and the results were plotted to show the tendency. As a result, one non-informative time point was demonstrated to be appropriate for clearance and two for both volume of distribution and constant of absorption in the present study. It was found that the estimates of the non-informative sampling time points developed in the method increase with increases of volume of distribution and the decrease of clearance and constant of absorption. Conclusion A rational sampling strategy during therapeutic drug monitoring can be established using the method present in the study.
基金Project(2012BAJ06B04)supported by"12th Five-Year Plan"National science and Technology,ChinaProject(2014-228)supported by Department of Housing and Urban Rural Development of Hebei,China
文摘The energy efficiency monitoring is an essential precondition for ground source heat pump system's controlling and energy saving operation. Based on the data monitoring applied in the school building, this work is focused on the parameters acquisition and operation analysis of the GSHP system in Tangshan. Results show the average COPs(coefficient of performance) are2.85 and 2.70 in summer and winter, respectively, and heat(cold) unbalance underground existed after whole year operation. The analysis of data also indicates that the direct borehole air-conditioning saved some power consumption obviously in the early stage of summer and energy saving of the GSHP system depended remarkably on its operation and management level. Besides the observation points of ground temperature are laid for a large-scale GSHP system, and the hydraulic balance of the pipes group needs to be concerned specially in safeguarding better reliability.
基金supported by the National Hi-Tech Research and Development Program of China (No. 2009AA11Z105)the sponsors of Hanxing Iron Ore Mine Administration Bureau for providing the research funds,insitu test assistance and monitor work
文摘The development and application of the ''digital mine'' concept in China depends heavily upon the use of remote sensing data as well as domestic expertise and awareness. Illegal mining of mineral resources has been a serious long term problem frustrating the Xishimen Iron Ore Mine management. This mine is located in Wu'an county in Hebei province, China. Illegal activities have led to enormous economic losses by interfering with the normal operation of the Xishimen mine and have ruined the surrounding environ- ment and the stability of the Mahe riverbed the crosses the mined area. This paper is based on field recon- naissance taken over many years around the mine area. The ground survey data are integrated with Differential Synthetic Aperture Radar Interferometry (D-InSAR) results from ALOS/PALSAR data to pin- point mining locations. By investigating the relationship between the resulting interferometric deforma- tion pattern and the mining schedule, which is known a priori, areas affected by illegal mining activities are identified. To some extent these areas indicate the location of the illegal site. The results clearly dem- onstrate D-InSAR's ability to cost-effectively monitor illegal mining activities.
基金Funding from the German Federal Ministry of Food,Agriculture and Consumer Protection(BMELV)
文摘Agricultural landscapes are essential for the conservation of biodiversity. Nevertheless, a negative trend continues to be observed in many rural areas for the most prominent indicator species group, the farmland birds. However, clear cause-effect relationships are rarely reported and sometimes difficult to deduce, especially from monitoring data which are based only on the detection of species and counts of the numbers of individuals. Because the identification of habitat preferences is a precondition for farmland bird biodiversity conservation efforts, a monitoring scheme for the simultaneous collection and analysis of bird and land use data was developed and tested. In order to assign the occurrence of bird species to land characteristics at various spatial scales and different land use and crop types, we applied a hierarchical structured sampling design. The spatial scales were ‘agricultural landscape', ‘agricultural landscape types', ‘field crops and other habitats' and ‘vegetation structures'. These scales were integrated with a novel concept, the ‘habitat matrix'(HM). This method was applied to farmland breeding bird abundances on 29 plots, each 1 km2 in size, by the use of the territory mapping method. The same plots were enlarged by a 100 m buffer and the sizes and location of habitats documented. Vegetation height, coverage and density were also recorded for all crop fields in the study area. We propose that this monitoring method facilitates the identification of scale dependent relationships between farmland bird habitat characteristics and bird abundance. This is demonstrated by the farmland bird species Corn Bunting(Emberiza calandra), Skylark(Alauda arvensis), and Whinchat(Saxicola rubetra). The breeding territories of these species reveal large differences within the various spatial scales ‘agricultural landscape', ‘agricultural landscape types' and ‘field crops'. Throughout the breeding season the abundances varied, dependent on the field crop and the development of vegetation structures(height, coverage, and density). HM-analysis led to the identification of specific habitat configurations preferred by individual bird species within the agricultural landscape. These findings indicate that the methodology has the potential to design monitoring schemes for the identification of cause-and-effects of landscape configuration, land use and land use changes on the habitat suitability and abundance of farmland birds.
基金provided by the National Natural Science Foundation of China (No.11002021)the Doctoral Subject,Foundation of the Ministry of Education of China (No.20070008012)+1 种基金the National High Technology Research and Development Program of China (No.2008AA062104)Team Program for Key Scientific and Technological innovation,Shaanxi Province of China (No.2013KCT-16)
文摘Horizontal section top-coal(HSTCC)caving offers a powerful method to efficiently excavate rude coal in steep and thick seams,and pre-blasting weakening has a profound effect on pursuing great production,high efficiency and good benefit under particular conditions like a small-scale working face with large-scale sectional caving height.+564-level HSTCC working face in B3–6coal seams of Jiangou Colliery in Urumqi was taken as study case for in situ industrial experiment.Total thickness of seams in the study case is about 50.0 m and average angel here is over 83°.In the industrial experiments,at first we adopted continuous charge machine and emulsion matrix explosive to substitute for traditional blasting schemes for specific geological settings in the study case.Hybrid analyses and assessments with blasting crack propagation analysis,abutment pressure monitoring prediction and economical benefit assessment were attributed to be able to attest pre-blasting weakening effects practically.Meanwhile crack propagation analysis after pre-blasting weakening showed that in all triple monitoring bore holes rock masses of top-coal would be fallen into three stages from the bottom up:fracture zone,plastic zone and elastic zone generally,and fracture toughness respectively in correspondent zones was calculated by the analytical formula:0.5616–0.8806,0.6403–0.9541 and0.7535–1.1900 MPa m1/2after pre-blasting weakening.Pressure monitoring prediction and economical benefit assessment also indicated that it was necessary to introduce the pre-blasting weakening with predominant blasting scheme from both views.For excavation in extremely steep and thick coal seams,relevant results would be a useful tool to study the mechanism of pre-blasting weakening both qualitatively and quantitatively.
基金Supported by the National High Technology Research and Development Programme of China (No. 2005AA121620, 2006AA01Z232)the Zhejiang Provincial Natural Science Foundation of China (No. Y1080935 )the Research Innovation Program for Graduate Students in Jiangsu Province (No. CX07B_ 110zF)
文摘Interact traffic classification is vital to the areas of network operation and management. Traditional classification methods such as port mapping and payload analysis are becoming increasingly difficult as newly emerged applications (e. g. Peer-to-Peer) using dynamic port numbers, masquerading techniques and encryption to avoid detection. This paper presents a machine learning (ML) based traffic classifica- tion scheme, which offers solutions to a variety of network activities and provides a platform of performance evaluation for the classifiers. The impact of dataset size, feature selection, number of application types and ML algorithm selection on classification performance is analyzed and demonstrated by the following experiments: (1) The genetic algorithm based feature selection can dramatically reduce the cost without diminishing classification accuracy. (2) The chosen ML algorithms can achieve high classification accuracy. Particularly, REPTree and C4.5 outperform the other ML algorithms when computational complexity and accuracy are both taken into account. (3) Larger dataset and fewer application types would result in better classification accuracy. Finally, early detection with only several initial packets is proposed for real-time network activity and it is proved to be feasible according to the preliminary results.
文摘Starting from the important role of "Taobao village" in the economic development, the thesis analysed the subjective and objective reasons and promoting group and draw the general process of urbanization. It discussed the different characteristics of "Taobao village" in different economic areas and roles played in urbanizing. It also propounded some constructive suggestion to activate the industry, including strengthening industry supervision, adjusting development patterns, and emphasizing innovation. The paper consists of literature analysis, case analysis and comparative analysis to complement the demonstration.
基金Supported by The Department of Veterans Affairs of the United States
文摘Esophageal cancer is mainly found in Asia and east Africa and is one of the deadliest cancers in the world.However,it has not garnered much attention in the Western world due to its low incidence rate.An increasing amount of data indicate that esophageal cancer,particularly esophageal adenocarcinoma,has been rising by 6-fold annually and is now becoming the fastest growing cancer in the United States.This rise has been associated with the increase of the obese population,as abdominal fat puts extra pressure on the stomach and causes gastroesophageal reflux disease(GERD).Long standing GERD can induce esophagitis and metaplasia and,ultimately,leads to adenocarcinoma.Acid suppression has been the main strategy to treat GERD;however,it has not been proven to control esophageal malignancy effectively.In fact,its side effects have triggered multiple warnings from regulatory agencies.The high mortality and fast growth of esophageal cancer demand more vigorous efforts to look into its deeper mechanisms and come up with better therapeutic options.
文摘Nowadays, information technology (IT) has become a part of the working culture and environment in many organizations. Originally, it is not a supportive tool to make any business successful, but it have become the backbone of successful business recently. Any non-IT organization could become dead and non-productive. When time comes, maybe it will fail in the business market. However, the usage of IT instruments must be carried out in good and conducive environment especially for business market. In this study, a basic and practical management about how to manage IT asset in small organizations will be discussed. Then this kind of management will be further discussed when the company become small medium organization. The implementation of IT infrastructure, the requirements, infrastructures, services, and platform from software to hardware and networking devices needs to be known. However, this study focuses on networking infrastructure such as networking equipments, servers, network monitoring software, costing, and management best practices.
文摘Based on the analysis of different requirements of energy management center construction and the data acquisition of various industries in wide area network, as well as the practices of real-lime online system, the paper puts forward the construction scheme of regional energy management center (REMC) which can achieve real time online monitoring of organizations' energy consumption via data collection, and also proposes the design idea of energy data acquisition based on national standards.