With long-term marine surveys and research,and especially with the development of new marine environment monitoring technologies,prodigious amounts of complex marine environmental data are generated,and continuously i...With long-term marine surveys and research,and especially with the development of new marine environment monitoring technologies,prodigious amounts of complex marine environmental data are generated,and continuously increase rapidly.Features of these data include massive volume,widespread distribution,multiple-sources,heterogeneous,multi-dimensional and dynamic in structure and time.The present study recommends an integrative visualization solution for these data,to enhance the visual display of data and data archives,and to develop a joint use of these data distributed among different organizations or communities.This study also analyses the web services technologies and defines the concept of the marine information gird,then focuses on the spatiotemporal visualization method and proposes a process-oriented spatiotemporal visualization method.We discuss how marine environmental data can be organized based on the spatiotemporal visualization method,and how organized data are represented for use with web services and stored in a reusable fashion.In addition,we provide an original visualization architecture that is integrative and based on the explored technologies.In the end,we propose a prototype system of marine environmental data of the South China Sea for visualizations of Argo floats,sea surface temperature fields,sea current fields,salinity,in-situ investigation data,and ocean stations.An integration visualization architecture is illustrated on the prototype system,which highlights the process-oriented temporal visualization method and demonstrates the benefit of the architecture and the methods described in this study.展开更多
OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world a...OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety.展开更多
Wastewater-based epidemiology is a new approach to monitor drug abuse. It involves collecting wastewater, analysis of residues of drugs or its metabolites in wastewater, and back-calculation of drug consumption by tak...Wastewater-based epidemiology is a new approach to monitor drug abuse. It involves collecting wastewater, analysis of residues of drugs or its metabolites in wastewater, and back-calculation of drug consumption by taking into account wastewater flow, stability of drug target residues in wastewater, and excretion rates of drugs/metabolites. Wastewater-based epidemiology has the advantages of being inexpensive and yielding more consistent and near real-time results. It has the great potential to supplement the existing drug monitoring methods. It can be used to build large-scale(regional, national, or even continental) monitoring networks that would yield spatial patterns and temporal trends in drug abuse. This paper described in detail the principle and procedures of this wastewater-based approach. Application of this approach across the globe was also reviewed. The uncertainties involved in the approach and knowledge gaps were identified. Finally, necessity, benefits, and feasibility to set up nation or province-wide monitoring networks based on wastewater analysis in China were discussed.展开更多
Monitoring the operational state of sensors promptly and the accurate diagnosis of faults are essential. This paper proposes an improved fault diagnosis scheme for sensors, which includes both fault detection and faul...Monitoring the operational state of sensors promptly and the accurate diagnosis of faults are essential. This paper proposes an improved fault diagnosis scheme for sensors, which includes both fault detection and fault identification. Firstly, trend analysis combined with least squares support vector machine（TA-LSSVM） method is proposed and implemented to detect faults. Secondly, an improved error correcting output coding-support vector machine（ECOC-SVM） based fault identification method is proposed to distinguish different sensor failure modes. To demonstrate the effectiveness of the proposed scheme, experiments are conducted with an MTi-series sensor, and some comparisons are made with other fault identification methods. The experimental results demonstrate that the proposed fault diagnosis scheme offers an essential improvement with detection real-time property and better identification accuracy.展开更多
基金Supported by the Knowledge Innovation Program of the Chinese Academy of Sciences (No.KZCX1-YW-12-04)the National High Technology Research and Development Program of China (863 Program) (Nos.2009AA12Z148,2007AA092202)Support for this study was provided by the Institute of Geographical Sciences and the Natural Resources Research,Chinese Academy of Science (IGSNRR,CAS) and the Institute of Oceanology, CAS
文摘With long-term marine surveys and research,and especially with the development of new marine environment monitoring technologies,prodigious amounts of complex marine environmental data are generated,and continuously increase rapidly.Features of these data include massive volume,widespread distribution,multiple-sources,heterogeneous,multi-dimensional and dynamic in structure and time.The present study recommends an integrative visualization solution for these data,to enhance the visual display of data and data archives,and to develop a joint use of these data distributed among different organizations or communities.This study also analyses the web services technologies and defines the concept of the marine information gird,then focuses on the spatiotemporal visualization method and proposes a process-oriented spatiotemporal visualization method.We discuss how marine environmental data can be organized based on the spatiotemporal visualization method,and how organized data are represented for use with web services and stored in a reusable fashion.In addition,we provide an original visualization architecture that is integrative and based on the explored technologies.In the end,we propose a prototype system of marine environmental data of the South China Sea for visualizations of Argo floats,sea surface temperature fields,sea current fields,salinity,in-situ investigation data,and ocean stations.An integration visualization architecture is illustrated on the prototype system,which highlights the process-oriented temporal visualization method and demonstrates the benefit of the architecture and the methods described in this study.
基金Sichuan Science and Technology Support Project:the Nested Case-control Study on Adverse Reaction Centralized Monitoring and Risk Factors of Leonurus Japonicus Injection(No.2014ZS0139)the Major State Basic Research Grant(973-program+2 种基金2011CB505406)Ph.D.Programs Foundation of Ministry of Education of China(No.2013-1210110001)State Administration of Traditional Chinese Medicine "Twelve-Five" Focus on Cultivating Subjects of Chinese Preventive Medicine[(2012)170]
文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety.
基金supported by the National Natural Science Foundation of China(Grant Nos.41371442&41671492)
文摘Wastewater-based epidemiology is a new approach to monitor drug abuse. It involves collecting wastewater, analysis of residues of drugs or its metabolites in wastewater, and back-calculation of drug consumption by taking into account wastewater flow, stability of drug target residues in wastewater, and excretion rates of drugs/metabolites. Wastewater-based epidemiology has the advantages of being inexpensive and yielding more consistent and near real-time results. It has the great potential to supplement the existing drug monitoring methods. It can be used to build large-scale(regional, national, or even continental) monitoring networks that would yield spatial patterns and temporal trends in drug abuse. This paper described in detail the principle and procedures of this wastewater-based approach. Application of this approach across the globe was also reviewed. The uncertainties involved in the approach and knowledge gaps were identified. Finally, necessity, benefits, and feasibility to set up nation or province-wide monitoring networks based on wastewater analysis in China were discussed.
基金supported in part by the National Natural Science Foundation of China under Grant Nos.61304254,61321002 and 61120106010the Key Exploration Project under Grant No.7131253
文摘Monitoring the operational state of sensors promptly and the accurate diagnosis of faults are essential. This paper proposes an improved fault diagnosis scheme for sensors, which includes both fault detection and fault identification. Firstly, trend analysis combined with least squares support vector machine（TA-LSSVM） method is proposed and implemented to detect faults. Secondly, an improved error correcting output coding-support vector machine（ECOC-SVM） based fault identification method is proposed to distinguish different sensor failure modes. To demonstrate the effectiveness of the proposed scheme, experiments are conducted with an MTi-series sensor, and some comparisons are made with other fault identification methods. The experimental results demonstrate that the proposed fault diagnosis scheme offers an essential improvement with detection real-time property and better identification accuracy.
