核电厂数字化人-机界面监视转移路径预测方法及其应用

核电厂操纵员在监视核电厂数字化人-机界面参数信息时,某些时刻难以判断下一个最可能的监视目标,从而导致监视延迟或转移失误的情况。为更好研监视路径预测问题,提出基于马尔可夫过程的监视过程预测路径规划方法,包括监视过程预测路径模型、监视过程预测路径规划算法、转移路径成功率算法。基于提出的方法,对核电厂蒸汽发生器传热管破裂事故操纵员监视转移行为进行分析,以数字化人-机界面作为t时刻监视任务的信息源节点,可以准确预测到下一个监视目标的转移路径,提高操纵员监视绩效并成功地降低监视失误风险。

数字化核电厂主控室操纵员监视行为转移规律研究

在数字化核电厂主控室中,监视反应堆系统运行状态是操纵员主要工作任务之一,也是操纵员正确控制反应堆系统运行的基础和前提。通过研究发现,操纵员的监视行为主要存在3种转移类型:规程转移、异常转移和交流转移。3种转移类型占总转移次数的百分比分别为:交流转移占29%、异常转移占14%、规程转移占36%,不能归入这3种类型的转移占21%。

Prognostic value of site-specific metastases in pancreatic adenocarcinoma: A Surveillance Epidemiology and End Results database analysis

To evaluate the prognostic value of site-specific metastases among patients with metastatic pancreatic carcinoma registered within the Surveillance, Epidemiology and End Results (SEER) database.METHODSSEER database (2010-2013) has been queried through SEER*Stat program to determine the presentation, treatment outcomes and prognostic outcomes of metastatic pancreatic adenocarcinoma according to the site of metastasis. In this study, metastatic pancreatic adenocarcinoma patients were classified according to the site of metastases (liver, lung, bone, brain and distant lymph nodes). We utilized chi-square test to compare the clinicopathological characteristics among different sites of metastases. We used Kaplan-Meier analysis and log-rank testing for survival comparisons. We employed Cox proportional model to perform multivariate analyses of the patient population; and accordingly hazard ratios with corresponding 95%CI were generated. Statistical significance was considered if a two-tailed P value < 0.05 was achieved.RESULTSA total of 13233 patients with stage IV pancreatic cancer and known sites of distant metastases were identified in the period from 2010-2013 and they were included into the current analysis. Patients with isolated distant nodal involvement or lung metastases have better overall and pancreatic cancer-specific survival compared to patients with isolated liver metastases (for overall survival: lung vs liver metastases: P < 0.0001; distant nodal vs liver metastases: P < 0.0001) (for pancreatic cancer-specific survival: lung vs liver metastases: P < 0.0001; distant nodal vs liver metastases: P < 0.0001). Multivariate analysis revealed that age < 65 years, white race, being married, female gender; surgery to the primary tumor and surgery to the metastatic disease were associated with better overall survival and pancreatic cancer-specific survival.CONCLUSIONPancreatic adenocarcinoma patients with isolated liver metastases have worse outcomes compared to patients with isolated lung or distant nodal metastases. Further research is needed to identify the highly selected subset of patients who may benefit from local treatment of the primary tumor and/or metastatic disease.

An chromatic dispersion monitoring method based on spectral-shift of SOA

A remnant dispersion monitoring method based on spectral-shift of SOA in high speed optical communication system with CSRZ format and single channel speed of 40 Gbit/s is proposed. The system performance can be optimized by careful choosing bandwidth and center wavelength of the optical fiber grating filter. The dynamical monitoring range is ±60 ps/nm and the monitoring precision is about 5 ps/nm. This method can be suitable for the application in dynamical dispersion compensation of high speed optical communication systems.

Roles of a metastasis-associated molecule, RTVP-1, in cancer immunosurveillance

Objective: To elucidate distinct functions of a recently identified cancer metastasis-associated molecule, related to testes-specific, vespid, and pathogenesis protein-1 (RTVP-1) in the mammalian immune system. Methods: Immunohistochemical assays and functional analysis on the immune system were performed on RTVP-/- mice and RTVP-1+/+ mice. Protein-protein interaction (PPI) was used to predict the functions of RTVP-1. Results: Abnormal lymphocyte growth kinetics and reduced numbers of CD8+ T cells were revealed in lymph nodes of RTVP-1-/- mice. Expression of phenotypic markers of maturation in bone marrow-derived dendritic cells (DC) was impaired in RTVP-1-/- DC following antigenic stimulation in vitro and RTVP-1-/- DC failed to provide normal CD4+ T cell stimulatory activities in vivo. RTVP-1-/- mice failed to generate normal CTL or antibody responses in vivo after vaccination. In vivo tumor challenge experiments using a mouse cancer cell line demonstrated that the growth rate of subcutaneous tumors in RTVP-1-/- mice was significantly increased and CD8+ T cell infiltration significantly reduced compared to RTVP-1+/+ mice. PPI showed that RTVP-1 protein closely interacted with molecules associated with immune response and cancer metastasis. Conclusion: RTVP-1 might function as a tumor metastasis suppressor and immunosurveillance molecule in cancer.

Strain transfer of surface-bonded fiber Bragg grating sensors for airship envelope structural health monitoring

This paper deals with an improved bonding approach of surface-bonded fiber Bragg grating (FBG) sensors for airship envelope structural health monitoring (SHM) under the strain transfer theory. A theoretical formula is derived from the proposed model to predict the strain transfer relationship between the airship envelope and fiber core. Then theoretical predictions are validated by numerical analysis using the finite element method (FEM). Finally, on the basis of the theoretical approach and numerical validation, parameters that influence the strain transfer rate from the airship envelope to fiber core and the ratio of effective sensing length are analyzed, and some meaningful conclusions are provided.