语段研究的新问题和新进展

本文在简要回顾Chomsky“经典”语段理论的基础上,首先提出了“经典”理论可能存在的问题,然后讨论了最新研究对这些问题的解决方案。语段理论的新发展主要体现在三个方面:1)语段的定义由静态语段发展为动态语段;2)语段运算规则中由强弱不可渗透条件的区分到词汇矩阵的重新定义;3)语段生成过程中,通过目标⁃探针理论中的特征系统(特征核查、赋值等)和反一致关系的重新定义,试图解释跨语言共有的句法依存关系等。

Recent advances in target identification by natural product based chemical probes

Natural products have been extensively used to treat diseases throughout human history. These are mainly because natural products normally target biological macromolecules selectively. Target identification could help us to develop new therapeutic agents and discover new biological pathways underlying human diseases. Herein, we highlight some recent examples of using natural products and their derivatives as chemical probes to identify the molecular targets and elucidate mode of action.