卡内基梅隆大学的研究人员发表于近期《生物医学与生物技术期刊》(Journal of Biomedicine and Biotechnology)中，论文题为Data Mining in Genomics and Proteomics的研究称,他们首次研究出可以从细胞的高解析率影像中，自动分类荧光...卡内基梅隆大学的研究人员发表于近期《生物医学与生物技术期刊》(Journal of Biomedicine and Biotechnology)中，论文题为Data Mining in Genomics and Proteomics的研究称,他们首次研究出可以从细胞的高解析率影像中，自动分类荧光标记蛋白质。这项技术开辟了一务新道路，可以鉴别哪些蛋白质聚集于细胞里，而分辨出疾病蛋白质和药物目标。展开更多
Sixteen pairs of two-component regulatory systems are identified in the genome of Staphylococcus epidermidis ATCC12228 strain, which is newly sequenced by our laboratory for Medical Molecular Virology and Chinese Nati...Sixteen pairs of two-component regulatory systems are identified in the genome of Staphylococcus epidermidis ATCC12228 strain, which is newly sequenced by our laboratory for Medical Molecular Virology and Chinese National Human Genome Center at Shanghai, by using bio- informatics analysis. Comparative analysis of the two- component regulatory systems in S. epidermidis and that of S. aureus and Bacillus subtilis shows that these systems may regulate some important biological functions, e.g. growth, biofilm formation, and expression of virulence factors in S. epidermidis. Two conserved domains, i.e. HATPase_c and REC domains, are found in all 16 pairs of two-component proteins. Homologous modelling analysis indicates that there are 4 similar HATPase_c domain structures of histidine kinases and 13 similar REC domain structures of response regulators, and there is one AMP-PNP binding pocket in the HATPase_c domain and three active aspartate residues in the REC domain. Preliminary experiment reveals that the bioinfor- matics analysis of the conserved domain structures in the two-component regulatory systems in S. epidermidis may provide useful information for discovery of potential drug target.展开更多
文摘卡内基梅隆大学的研究人员发表于近期《生物医学与生物技术期刊》(Journal of Biomedicine and Biotechnology)中，论文题为Data Mining in Genomics and Proteomics的研究称,他们首次研究出可以从细胞的高解析率影像中，自动分类荧光标记蛋白质。这项技术开辟了一务新道路，可以鉴别哪些蛋白质聚集于细胞里，而分辨出疾病蛋白质和药物目标。
文摘Sixteen pairs of two-component regulatory systems are identified in the genome of Staphylococcus epidermidis ATCC12228 strain, which is newly sequenced by our laboratory for Medical Molecular Virology and Chinese National Human Genome Center at Shanghai, by using bio- informatics analysis. Comparative analysis of the two- component regulatory systems in S. epidermidis and that of S. aureus and Bacillus subtilis shows that these systems may regulate some important biological functions, e.g. growth, biofilm formation, and expression of virulence factors in S. epidermidis. Two conserved domains, i.e. HATPase_c and REC domains, are found in all 16 pairs of two-component proteins. Homologous modelling analysis indicates that there are 4 similar HATPase_c domain structures of histidine kinases and 13 similar REC domain structures of response regulators, and there is one AMP-PNP binding pocket in the HATPase_c domain and three active aspartate residues in the REC domain. Preliminary experiment reveals that the bioinfor- matics analysis of the conserved domain structures in the two-component regulatory systems in S. epidermidis may provide useful information for discovery of potential drug target.
