Objectives.To examine the prognostic significance of the protein expression of E-cadherin,α-,β-,andγ-catenin in early squamous cervical carcinoma (SCC).Methods.We studied 219patients who underwent r adical hysterec...Objectives.To examine the prognostic significance of the protein expression of E-cadherin,α-,β-,andγ-catenin in early squamous cervical carcinoma (SCC).Methods.We studied 219patients who underwent r adical hysterectomy and bilateral lymphadenectomy at ou r institution for stage IB SCC between 1987and 1993.Immunoh istochemistry using monoclonal antibodies against E-cadherin,α-,β-,andγ-catenin was used to examine protein expression.Ten patients who underwent hysterectom y for uterine prolapse served as controls.Results.Membra ne expression for E-cadherin,α-,β-,andγ-catenin was decreased and low expression(≤50%positive cells)was found in 198/219(90%),154/219(70%),157/219(72%),and 181/219(83%)tumors,respectively,and high(>50%pos-itive cells)in 21/219(10%),65/219(30%),62/219(28%),and 38/219(17%)tumors,respectively.In u-nivariate analysis,all classical c linicopathological param-eters but none of the investigated pr oteins were associated with prognosis.In multivariate analysis,only deep stromal invasion was independently related to survival.Conclu-sion.E-cadherin,α-,β-,andγ-catenin were not inde-pendently associated with prognosis in stage IB SCC.展开更多
文摘Objectives.To examine the prognostic significance of the protein expression of E-cadherin,α-,β-,andγ-catenin in early squamous cervical carcinoma (SCC).Methods.We studied 219patients who underwent r adical hysterectomy and bilateral lymphadenectomy at ou r institution for stage IB SCC between 1987and 1993.Immunoh istochemistry using monoclonal antibodies against E-cadherin,α-,β-,andγ-catenin was used to examine protein expression.Ten patients who underwent hysterectom y for uterine prolapse served as controls.Results.Membra ne expression for E-cadherin,α-,β-,andγ-catenin was decreased and low expression(≤50%positive cells)was found in 198/219(90%),154/219(70%),157/219(72%),and 181/219(83%)tumors,respectively,and high(>50%pos-itive cells)in 21/219(10%),65/219(30%),62/219(28%),and 38/219(17%)tumors,respectively.In u-nivariate analysis,all classical c linicopathological param-eters but none of the investigated pr oteins were associated with prognosis.In multivariate analysis,only deep stromal invasion was independently related to survival.Conclu-sion.E-cadherin,α-,β-,andγ-catenin were not inde-pendently associated with prognosis in stage IB SCC.
