Objective： The aim of the study was to compare the difference of dose distribution in clinical target volume and organ at risk （OAR） between five-field intensity-modulated radiotherapy （IMRT） and conventional thr...Objective： The aim of the study was to compare the difference of dose distribution in clinical target volume and organ at risk （OAR） between five-field intensity-modulated radiotherapy （IMRT） and conventional three-dimensional conformal radiotherapy （3DCRT） in the radiotherapy of rectal cancer. Methods： Fifteen patients with rectal cancer treated with radio- therapy （RT） were retrospectively analyzed. Among the patients, seven received RT preoperatively and 8 postoperatively. The target volume and the OARs such as the small bowel, bladder and femoral heads were contoured for each patient. 3DCRT-plan and IMRT-plan were performed for each patient respectively, with the prescribed dose covering at least 95% of the planning target volume （PTV）. The conformity index （CI） and homogeneity index （HI） were used for evaluation of the dose distribution in the target volume, and the Dx% （the lowest dose to the x% volume of the OARs that received the highest dose of irradiation） and the mean dose were used for evaluation of the dose to OARs. Paired-T test was used for companson of the difference between the two plans. Results： In the IMRT-plan and 3DCRT-plan, the CI were 0.94 and 0.87 （P = 0.000） and the HI were 1.13 and 1.17, respectively （P = 0.001）. For small bowel, the D30%, D50% and the mean dose were 19.67 Gy, 15.13 Gy and 18.81 Gy in the IMRT-plan and 25.20 Gy, 22.20 Gy and 22.89 Gy in the 3DCRT-plan, respectively （P 〈 0.001 for all pairs of parameters）. For bladder, the D30%, D50%, and the mean dose were 24.80 Gy, 34.20 Gy and 28.70 Gy in the IMRT- plan, and 35.07 Gy, 44.67 Gy and 35.68 Gy in the 3DCRT-plan, respectively （P 〈 0.001 for all pairs of parameters）. For femoral heads, the D5% in the IMRT-plan and 3DCRT-plan were 40.6 Gy and 40.47 Gy, respectively （P = 0.936）, and the mean dose were 30.14 Gy and 25.57 Gy, respectively （P = 0.001）. Conclusion： Five-field IMRT-plan is better than 3DCRT-plan in the conformity and the dose homogeneity within target volume and also better in sparing the small bowel and bladder.展开更多
The management of colon and rectal cancer has changed dramatically over the last 25 years. The use of adjuvant therapies has become standard practice in locally advanced （stage M and selected stage 11） colorectal ca...The management of colon and rectal cancer has changed dramatically over the last 25 years. The use of adjuvant therapies has become standard practice in locally advanced （stage M and selected stage 11） colorectal cancer. Improved surgical techniques, chemotherapeutics and radiotherapy are resulting in higher cure rates and the development of agents targeting proliferative and angiogenic pathways offer further promise. Here we explore risk factors for local and distant recurrence after resection of colon and rectal cancer, and the role of adjuvant treatments. Discussion will focus on the evidence base for adjuvant therapies utilised in colorectal cancer, and the treatment of sub-groups such as the elderly and stage 11 disease. The role of adjuvant radiotherapy in rectal cancer in reduction of recurrence will be explored and the role and optimal methods for surveillance post-curative resection with or without adjuvant therapy will also be addressed.展开更多
The wet oxidation of AlGaAs with high Al content in a distributed Bragg reflectors （DBR） is studied by scanning electron microscopy （SEM） and transmission electron microscopy （TEM）. Some voids distribute along t...The wet oxidation of AlGaAs with high Al content in a distributed Bragg reflectors （DBR） is studied by scanning electron microscopy （SEM） and transmission electron microscopy （TEM）. Some voids distribute along the oxide/GaAs interfaces due to the stress induced by the wet oxidation of the AlGaAs layers. These voids decrease the shrinkage of the Al2O3 layers to 8% instead of the theoretical 20% when compared to the unoxidized AlGaAs layers. With the extension of oxidation time, the reactants are more completely transported to the front interface and the products are more completely transported out along the porous interfaces. As a result,the oxide quality is better.展开更多
The downward shortwave radiation(DSR) is an essential parameter of land surface radiation budget and many land surface models that characterize hydrological,ecological and biogeochemical processes.The new Global LAnd ...The downward shortwave radiation(DSR) is an essential parameter of land surface radiation budget and many land surface models that characterize hydrological,ecological and biogeochemical processes.The new Global LAnd Surface Satellite(GLASS) DSR datasets have been generated recently using multiple satellite data in China.This study investigates the performances of direct comparison approach,which is mostly used for validation of surface insolation retrieved from satellite data over the plain area,and indirect comparison approach,which needs a fine resolution map of DSR as reference,for validation of GLASS DSR product in time-steps of 1 and 3 hours over three Chinese Ecosystem Research Network sites located in the rugged surface.Results suggest that it probably has a large uncertainty to assess GLASS DSR product using the direct comparison method between GLASS surface insolation and field measurements over complex terrain,especially at Mt.Gongga 3,000 m station with root mean square error of 279.04 and 229.06 W/m2in time-steps of 1 and 3 hours,respectively.Further improvement for validation of GLASS DSR product in the rugged surface is suggested by generation of a fine resolution map of surface insolation and comparison of the aggregated fine resolution map with GLASS product in the rugged surface.The validation experience demonstrates that the GLASS DSR algorithm is satisfactory with determination coefficient of 0.83 and root mean square error of 81.91W/m2over three Chinese Ecosystem Research Network sites,although GLASS product overestimates DSR compared to the aggregated fine resolution map of surface insolation.展开更多
AIM:To assess the clinical role of monoclonal immunoscintigraphy for the detection of metastasis and recurrence of colorectal cancer.METHODS:Monoclonal immunoscintigraphy was performed in patients operated on for colo...AIM:To assess the clinical role of monoclonal immunoscintigraphy for the detection of metastasis and recurrence of colorectal cancer.METHODS:Monoclonal immunoscintigraphy was performed in patients operated on for colorectal adenocar-cinoma suspected of local recurrence and metastatic disease.The results were compared with conventional diagnostics.RESULTS:Immunoscintigraphic investigation was done in 53 patients.Tumor recurrence occurred in 38 patients,and was confirmed by other diagnostic modalities in 35.In 15 patients,immunoscintigraphic findings were negative,and confirmed in 14 with other diagnostic methods.Comparative analysis confirmed good correlation of immunoscintigraphic findings and the results of conventional diagnostics and the level of tumor marker carcinoembryonic antigen.Statistical analysis of parameters of radiopharmaceutical groups imacis,indimacis and oncoscint presented homogenous characteristics all of three radiopharmaceuticals.The analysis of immunoscintigraphic target focus was clearly improved using tomography.CONCLUSION:Immunoscintigraphy is highly specific and has a good predictive value in local recurrence of colorectal cancer.展开更多
The LCLS-II （linac coherent light source II） will build on the success of the world＇s most powerful X-ray laser： the LCLS （linac coherent light source）. It will add two new X-ray laser beams and room for additio...The LCLS-II （linac coherent light source II） will build on the success of the world＇s most powerful X-ray laser： the LCLS （linac coherent light source）. It will add two new X-ray laser beams and room for additional new instruments, thus greatly increasing the number of experiments carried out each year. Multiple operation modes are proposed to accommodate a variety of user requirements. There are a large number of variables and objectives in the design. For each operation mode, MOGA （multi-objective genetic algorithm） is applied to optimize the machine parameters in order to minimize the jitters, energy spread, collective effects and emittance.展开更多
Magnetic Fe films grown on single-crystal Mg O(001) and(011) substrates were prepared by direct current magnetron sputtering. The experimental results showed that by applying an external magnetic field of about 300 Oe...Magnetic Fe films grown on single-crystal Mg O(001) and(011) substrates were prepared by direct current magnetron sputtering. The experimental results showed that by applying an external magnetic field of about 300 Oe to film during deposition, a fourfold cubic magnetic anisotropy on Mg O(001) substrate and a twofold uniaxial magnetic anisotropy on Mg O(011) substrate were generated, compared to the isotropic magnetization of Fe film grown without applying the external magnetic field.Our results suggested that external magnetic field during preparation effectively induced relatively higher surface mobility of sputtered Fe atoms and further promoted the crystallization of Fe film and the enhancement of magnetic anisotropy.展开更多
Based on the structure and dimensions of a vertical ZnO nanorod array(V-ZNA)sample,an ideal 2-D photonic crystal model was established.The optical properties of the V-ZNAs were analyzed with finite-difference time-dom...Based on the structure and dimensions of a vertical ZnO nanorod array(V-ZNA)sample,an ideal 2-D photonic crystal model was established.The optical properties of the V-ZNAs were analyzed with finite-difference time-domain(FDTD)method,and the influences of the geometry parameters,including the circumcircle diameters of the top and bottom surfaces(Dt and Db)and the height(H)of the nanorods,and the pitch between each column(L),were discussed.High transmittance and low reflectance in the waveband of 400–800 nm were proved,and the highest transmittance can be obtained with Dt<50 nm,H=200 nm,and Db/L=0.85,which was verified by Effective Index Method(EIM).The result indicates that V-ZNAs can be used as excellent light coupling element and antireflection material for solar energy applications.展开更多
文摘Objective： The aim of the study was to compare the difference of dose distribution in clinical target volume and organ at risk （OAR） between five-field intensity-modulated radiotherapy （IMRT） and conventional three-dimensional conformal radiotherapy （3DCRT） in the radiotherapy of rectal cancer. Methods： Fifteen patients with rectal cancer treated with radio- therapy （RT） were retrospectively analyzed. Among the patients, seven received RT preoperatively and 8 postoperatively. The target volume and the OARs such as the small bowel, bladder and femoral heads were contoured for each patient. 3DCRT-plan and IMRT-plan were performed for each patient respectively, with the prescribed dose covering at least 95% of the planning target volume （PTV）. The conformity index （CI） and homogeneity index （HI） were used for evaluation of the dose distribution in the target volume, and the Dx% （the lowest dose to the x% volume of the OARs that received the highest dose of irradiation） and the mean dose were used for evaluation of the dose to OARs. Paired-T test was used for companson of the difference between the two plans. Results： In the IMRT-plan and 3DCRT-plan, the CI were 0.94 and 0.87 （P = 0.000） and the HI were 1.13 and 1.17, respectively （P = 0.001）. For small bowel, the D30%, D50% and the mean dose were 19.67 Gy, 15.13 Gy and 18.81 Gy in the IMRT-plan and 25.20 Gy, 22.20 Gy and 22.89 Gy in the 3DCRT-plan, respectively （P 〈 0.001 for all pairs of parameters）. For bladder, the D30%, D50%, and the mean dose were 24.80 Gy, 34.20 Gy and 28.70 Gy in the IMRT- plan, and 35.07 Gy, 44.67 Gy and 35.68 Gy in the 3DCRT-plan, respectively （P 〈 0.001 for all pairs of parameters）. For femoral heads, the D5% in the IMRT-plan and 3DCRT-plan were 40.6 Gy and 40.47 Gy, respectively （P = 0.936）, and the mean dose were 30.14 Gy and 25.57 Gy, respectively （P = 0.001）. Conclusion： Five-field IMRT-plan is better than 3DCRT-plan in the conformity and the dose homogeneity within target volume and also better in sparing the small bowel and bladder.
文摘The management of colon and rectal cancer has changed dramatically over the last 25 years. The use of adjuvant therapies has become standard practice in locally advanced （stage M and selected stage 11） colorectal cancer. Improved surgical techniques, chemotherapeutics and radiotherapy are resulting in higher cure rates and the development of agents targeting proliferative and angiogenic pathways offer further promise. Here we explore risk factors for local and distant recurrence after resection of colon and rectal cancer, and the role of adjuvant treatments. Discussion will focus on the evidence base for adjuvant therapies utilised in colorectal cancer, and the treatment of sub-groups such as the elderly and stage 11 disease. The role of adjuvant radiotherapy in rectal cancer in reduction of recurrence will be explored and the role and optimal methods for surveillance post-curative resection with or without adjuvant therapy will also be addressed.
文摘The wet oxidation of AlGaAs with high Al content in a distributed Bragg reflectors （DBR） is studied by scanning electron microscopy （SEM） and transmission electron microscopy （TEM）. Some voids distribute along the oxide/GaAs interfaces due to the stress induced by the wet oxidation of the AlGaAs layers. These voids decrease the shrinkage of the Al2O3 layers to 8% instead of the theoretical 20% when compared to the unoxidized AlGaAs layers. With the extension of oxidation time, the reactants are more completely transported to the front interface and the products are more completely transported out along the porous interfaces. As a result,the oxide quality is better.
基金supported jointly by the "Hundred Talents" Projects of Chinese Academy of Sciences (CAS) and Sichuan ProvinceStrategic Priority Research Program-Climate Change: Carbon Budget and Related Issues (Grant No. XDA05050105)+2 种基金International Cooperation Partner Program of Innovative Team, CAS (Grant No. KZZD-EW-TZ-06)Open Foundation of BNU Center for Global Change Data Processing and AnalysisYoung Foundation of Institute of Mountain Hazards and Environment, CAS
文摘The downward shortwave radiation(DSR) is an essential parameter of land surface radiation budget and many land surface models that characterize hydrological,ecological and biogeochemical processes.The new Global LAnd Surface Satellite(GLASS) DSR datasets have been generated recently using multiple satellite data in China.This study investigates the performances of direct comparison approach,which is mostly used for validation of surface insolation retrieved from satellite data over the plain area,and indirect comparison approach,which needs a fine resolution map of DSR as reference,for validation of GLASS DSR product in time-steps of 1 and 3 hours over three Chinese Ecosystem Research Network sites located in the rugged surface.Results suggest that it probably has a large uncertainty to assess GLASS DSR product using the direct comparison method between GLASS surface insolation and field measurements over complex terrain,especially at Mt.Gongga 3,000 m station with root mean square error of 279.04 and 229.06 W/m2in time-steps of 1 and 3 hours,respectively.Further improvement for validation of GLASS DSR product in the rugged surface is suggested by generation of a fine resolution map of surface insolation and comparison of the aggregated fine resolution map with GLASS product in the rugged surface.The validation experience demonstrates that the GLASS DSR algorithm is satisfactory with determination coefficient of 0.83 and root mean square error of 81.91W/m2over three Chinese Ecosystem Research Network sites,although GLASS product overestimates DSR compared to the aggregated fine resolution map of surface insolation.
基金Supported by A Grant of the Ministry of Science of the Republic of Serbia,No.175018
文摘AIM:To assess the clinical role of monoclonal immunoscintigraphy for the detection of metastasis and recurrence of colorectal cancer.METHODS:Monoclonal immunoscintigraphy was performed in patients operated on for colorectal adenocar-cinoma suspected of local recurrence and metastatic disease.The results were compared with conventional diagnostics.RESULTS:Immunoscintigraphic investigation was done in 53 patients.Tumor recurrence occurred in 38 patients,and was confirmed by other diagnostic modalities in 35.In 15 patients,immunoscintigraphic findings were negative,and confirmed in 14 with other diagnostic methods.Comparative analysis confirmed good correlation of immunoscintigraphic findings and the results of conventional diagnostics and the level of tumor marker carcinoembryonic antigen.Statistical analysis of parameters of radiopharmaceutical groups imacis,indimacis and oncoscint presented homogenous characteristics all of three radiopharmaceuticals.The analysis of immunoscintigraphic target focus was clearly improved using tomography.CONCLUSION:Immunoscintigraphy is highly specific and has a good predictive value in local recurrence of colorectal cancer.
文摘The LCLS-II （linac coherent light source II） will build on the success of the world＇s most powerful X-ray laser： the LCLS （linac coherent light source）. It will add two new X-ray laser beams and room for additional new instruments, thus greatly increasing the number of experiments carried out each year. Multiple operation modes are proposed to accommodate a variety of user requirements. There are a large number of variables and objectives in the design. For each operation mode, MOGA （multi-objective genetic algorithm） is applied to optimize the machine parameters in order to minimize the jitters, energy spread, collective effects and emittance.
基金supported by the National Natural Science Foundation of China(51332001 and 51402164)Tsinghua University Initiative Scientific Research Program(2014Z21010 and 2014Z01006)
文摘Magnetic Fe films grown on single-crystal Mg O(001) and(011) substrates were prepared by direct current magnetron sputtering. The experimental results showed that by applying an external magnetic field of about 300 Oe to film during deposition, a fourfold cubic magnetic anisotropy on Mg O(001) substrate and a twofold uniaxial magnetic anisotropy on Mg O(011) substrate were generated, compared to the isotropic magnetization of Fe film grown without applying the external magnetic field.Our results suggested that external magnetic field during preparation effectively induced relatively higher surface mobility of sputtered Fe atoms and further promoted the crystallization of Fe film and the enhancement of magnetic anisotropy.
基金supported by the National Basic Research Program of China("973" Project)(Grant No.2009CB939904)the Fundamental Research Funds for the Central Universitiesthe Key Laboratory of Inorganic Coating Materials,Chinese Academy of Sciences
文摘Based on the structure and dimensions of a vertical ZnO nanorod array(V-ZNA)sample,an ideal 2-D photonic crystal model was established.The optical properties of the V-ZNAs were analyzed with finite-difference time-domain(FDTD)method,and the influences of the geometry parameters,including the circumcircle diameters of the top and bottom surfaces(Dt and Db)and the height(H)of the nanorods,and the pitch between each column(L),were discussed.High transmittance and low reflectance in the waveband of 400–800 nm were proved,and the highest transmittance can be obtained with Dt<50 nm,H=200 nm,and Db/L=0.85,which was verified by Effective Index Method(EIM).The result indicates that V-ZNAs can be used as excellent light coupling element and antireflection material for solar energy applications.
