The management of colon and rectal cancer has changed dramatically over the last 25 years. The use of adjuvant therapies has become standard practice in locally advanced （stage M and selected stage 11） colorectal ca...The management of colon and rectal cancer has changed dramatically over the last 25 years. The use of adjuvant therapies has become standard practice in locally advanced （stage M and selected stage 11） colorectal cancer. Improved surgical techniques, chemotherapeutics and radiotherapy are resulting in higher cure rates and the development of agents targeting proliferative and angiogenic pathways offer further promise. Here we explore risk factors for local and distant recurrence after resection of colon and rectal cancer, and the role of adjuvant treatments. Discussion will focus on the evidence base for adjuvant therapies utilised in colorectal cancer, and the treatment of sub-groups such as the elderly and stage 11 disease. The role of adjuvant radiotherapy in rectal cancer in reduction of recurrence will be explored and the role and optimal methods for surveillance post-curative resection with or without adjuvant therapy will also be addressed.展开更多
For the rapid calibration of multi-line structured light system,a method based on Plücker line was proposed.Most of the conventional line-structured light calibration methods extract the feature points and transf...For the rapid calibration of multi-line structured light system,a method based on Plücker line was proposed.Most of the conventional line-structured light calibration methods extract the feature points and transform the coordinates of points to obtain the plane equation.However,a large number of points lead to complicated operation which is not suitable for the application scenarios of multi-line structured light.To solve this issue,a new calibration method was proposed that applied the form of Plücker matrix throughout the whole calibration process,instead of using the point characteristics directly.The advantage of this method is that the light plane equation can be obtained quickly and accurately in the camera coordinate frame.Correspondingly a planar target particularly for calibrating multi-line structured light was also designed.The regular lines were transformed into Plücker lines by extending the two-dimensional image plane and defining a new image space.To transform the coordinate frame of Plücker lines,the perspective projection mathematical model was re-expressed based on the Plücker matrix.According to the properties of the line and plane in the Plücker space,a linear matrix equation was efficiently constructed by combining the Plücker matrices of several coplanar lines so that the line-structured light plane equation could be furtherly solved.The experiments performed validate the proposed method and demonstrate the significant improvement in the calibration accuracy,when the test distance is 1.8 m,the root mean square(RMS)error of the three-dimensional point is within 0.08 mm.展开更多
AIM:To gain mechanistic insights into the role played by epidermal growth factor receptor (EGFR) in the regulation of vascular endothelial growth factors (VEGFs) in colorectal cancer (CRC). METHODS:The impact of high-...AIM:To gain mechanistic insights into the role played by epidermal growth factor receptor (EGFR) in the regulation of vascular endothelial growth factors (VEGFs) in colorectal cancer (CRC). METHODS:The impact of high-level expression of the growth factor receptors EGFR and VEGF receptor (VEGFR)3 and the VEGFR3 ligands VEGF-C and VEGF-D on disease progression and prognosis in human CRC was investigated in 108 patients using immunohistochemistry. Furthermore, the expression of the lymphangiogenic factors in response to the modulation of EGFR signalling by the EGFR-targeted monoclonal antibody cetuximab was investigated at the mRNA and protein level in human SW480 and SW620 CRC cell lines and a mouse xenograft model. RESULTS: Human CRC specimens and cell lines displayed EGFR, VEGF-C and VEGF-D expression with varying intensities. VEGF-C expression was associated with histological grade. Strong expression of VEGF-D was significantly associated with lymph node metastases and linked to a trend for decreased survival in lymph node-positive patients. EGFR blockade with cetuximab resulted in a significant decrease of VEGF-D expression in vitro and in vivo. CONCLUSION:In conclusion, the expression of VEGF-D in colorectal tumours is significantly associated with lymphatic involvement in CRC patients and such expression might be blocked effectively by cetuximab.展开更多
Objective:The aim of the study was to observe the efficacies of 89Sr and combination treatments with regional extra-beam radiotherapy for cancer patients with multiple bone metastasis.Methods:A total of 106 patients w...Objective:The aim of the study was to observe the efficacies of 89Sr and combination treatments with regional extra-beam radiotherapy for cancer patients with multiple bone metastasis.Methods:A total of 106 patients were divided into two groups, and each group were 53 patients:the simple 89Sr treatment group (simple group), and local radiotherapy and 89Sr treatment group (combination group).The dose of 4 mci of 89Sr was made in every patient by intravenous injection, 6 MV linear accelerator external irradiation dose was given 30-60 Gy/2-4 weeks.Results:The effective rates of simple and combination groups were respectively 83.01% and 90.56%; the effective improvement rates of the bone focus of two groups were 75.48% and 86.8%, respectively.There was homologous improvement in general conditions.Conclusion:89Sr treatment has a certain effect to the cancers of whole-body multiple bone metastases.And the combined treatment with regional radiotherapy can improve the efficacy and life quality of cancer patients with bone metastasis.展开更多
This paper proposes a new type of pulse launcher that applies the principle of linear motors. The stator, viz. gun barrel, of the launcher has a new structure of one segment of iron core consisting of 3 staggered lami...This paper proposes a new type of pulse launcher that applies the principle of linear motors. The stator, viz. gun barrel, of the launcher has a new structure of one segment of iron core consisting of 3 staggered laminations. This structure is helpful in advancing the thrust force per volume. Based on introducing the structure and the working principles, this paper resolves the electromagnetic thrusting force and performs mechanical analysis and experiments on the sample launcher. The research shows that this launcher is simple and brushless structure with brief controlling.展开更多
The dosimetric inter-comparison studies carry pertinent significance to ensure uniform radiation dose delivery for clinical trials. This paper investigates the comparative performance analysis of an X-ray high power l...The dosimetric inter-comparison studies carry pertinent significance to ensure uniform radiation dose delivery for clinical trials. This paper investigates the comparative performance analysis of an X-ray high power linear accelerator per- formed by the International Dosimetry Survey Mission and Institute of Nuclear Medicine ＆ Oncology （INMOL）, Lahore. The measurements were made using cylindrical ionization chambers based on the International Atomic Energy Agency （IAEA） TRS-398 protocol for absorbed dose-to-water dosimetric standards, and the percentage deviation was found to be between 0.5 % - 1%. The dosimetric analysis concerning linear X-ray accelerator output performed by INMOL, Lahore was found to be in good agreement with the results of IAEA Dosimtery Survey Mission.展开更多
Objective:The aim of this study was to measure the leakage by two methods with ion chamber and ready packs film,and to investigate the feasibility and the advantages of using two dosimetry methods for assessing leakag...Objective:The aim of this study was to measure the leakage by two methods with ion chamber and ready packs film,and to investigate the feasibility and the advantages of using two dosimetry methods for assessing leakage radiation around the head of the linear accelerators.Methods:Measurements were performed using a 30 cm3ion chamber;the gantry at 0°,the X-ray head at 0°,the field size at between the central axis and a plane surface at a FSD of 100 as a reference,a series of concentric circles having radii of 50,75,and 100 cm with their common centre at the reference point.The absorbed dose was measured at the reference point,and this would be used as the reference dose.With the diaphragm closed,the measurements were taken along the circumference of the three circles and at 45°intervals.Results:Leakage radiations while the treatment head was in the vertical position varied between 0.016%–0.04%.With the head lying horizontally,leakage radiation was the same order magnitude and varied between 0.02%–0.07%.In the second method,the verification was accomplished by closing the collimator jaws and covering the head of the treatment unit with the ready pack films.The films were marked to permit the determination of their positions on the machine after exposed and processed.With the diaphragm closed,and the ready packs films around the linear accelerator the beam turned on for 2500 cGy(2500 MU).The optical density of these films was measured and compared with this of the reference dose.Leakage radiation varied according to the film positions and the magnitude of leakage was between 0.005%–0.075%.Conclusion:The differences between the values of the leakage radiation levels observed at different measurement points do not only reflect differences in the effective shielding thickness of the head wall,but are also related to differences in the distances between the target and the measurement points.The experimental errors involved in dosimetric measurement also contribute to such differences.展开更多
Combustion noise takes large proportion in diesel engine noise and the studies of its influence factors play an important role in noise reduction. Engine noise and cylinder pressure measurement experiments were carrie...Combustion noise takes large proportion in diesel engine noise and the studies of its influence factors play an important role in noise reduction. Engine noise and cylinder pressure measurement experiments were carried out. And the improved attenuation curves were obtained, by which the engine noise was predicted. The effect of fuel injection parameters in combustion noise was investigated during the combustion process. At last, the method combining single variable optimization and multivariate combination was introduced to online optimize the combustion noise. The results show that injection parameters can affect the cylinder pressure rise rate and heat release rate, and consequently affect the cylinder pressure load and pressure oscillation to influence the combustion noise. Among these parameters, main injection advance angle has the greatest influence on the combustion noise, while the pilot injection interval time takes the second place, and the pilot injection quantity is of minimal impact. After the optimal design of the combustion noise, the average sound pressure level of the engine is distinctly reduced by 1.0 d B(A) generally. Meanwhile, the power, emission and economy performances are ensured.展开更多
文摘The management of colon and rectal cancer has changed dramatically over the last 25 years. The use of adjuvant therapies has become standard practice in locally advanced （stage M and selected stage 11） colorectal cancer. Improved surgical techniques, chemotherapeutics and radiotherapy are resulting in higher cure rates and the development of agents targeting proliferative and angiogenic pathways offer further promise. Here we explore risk factors for local and distant recurrence after resection of colon and rectal cancer, and the role of adjuvant treatments. Discussion will focus on the evidence base for adjuvant therapies utilised in colorectal cancer, and the treatment of sub-groups such as the elderly and stage 11 disease. The role of adjuvant radiotherapy in rectal cancer in reduction of recurrence will be explored and the role and optimal methods for surveillance post-curative resection with or without adjuvant therapy will also be addressed.
基金National Natural Science Foundation of China(No.51575388)。
文摘For the rapid calibration of multi-line structured light system,a method based on Plücker line was proposed.Most of the conventional line-structured light calibration methods extract the feature points and transform the coordinates of points to obtain the plane equation.However,a large number of points lead to complicated operation which is not suitable for the application scenarios of multi-line structured light.To solve this issue,a new calibration method was proposed that applied the form of Plücker matrix throughout the whole calibration process,instead of using the point characteristics directly.The advantage of this method is that the light plane equation can be obtained quickly and accurately in the camera coordinate frame.Correspondingly a planar target particularly for calibrating multi-line structured light was also designed.The regular lines were transformed into Plücker lines by extending the two-dimensional image plane and defining a new image space.To transform the coordinate frame of Plücker lines,the perspective projection mathematical model was re-expressed based on the Plücker matrix.According to the properties of the line and plane in the Plücker space,a linear matrix equation was efficiently constructed by combining the Plücker matrices of several coplanar lines so that the line-structured light plane equation could be furtherly solved.The experiments performed validate the proposed method and demonstrate the significant improvement in the calibration accuracy,when the test distance is 1.8 m,the root mean square(RMS)error of the three-dimensional point is within 0.08 mm.
文摘AIM:To gain mechanistic insights into the role played by epidermal growth factor receptor (EGFR) in the regulation of vascular endothelial growth factors (VEGFs) in colorectal cancer (CRC). METHODS:The impact of high-level expression of the growth factor receptors EGFR and VEGF receptor (VEGFR)3 and the VEGFR3 ligands VEGF-C and VEGF-D on disease progression and prognosis in human CRC was investigated in 108 patients using immunohistochemistry. Furthermore, the expression of the lymphangiogenic factors in response to the modulation of EGFR signalling by the EGFR-targeted monoclonal antibody cetuximab was investigated at the mRNA and protein level in human SW480 and SW620 CRC cell lines and a mouse xenograft model. RESULTS: Human CRC specimens and cell lines displayed EGFR, VEGF-C and VEGF-D expression with varying intensities. VEGF-C expression was associated with histological grade. Strong expression of VEGF-D was significantly associated with lymph node metastases and linked to a trend for decreased survival in lymph node-positive patients. EGFR blockade with cetuximab resulted in a significant decrease of VEGF-D expression in vitro and in vivo. CONCLUSION:In conclusion, the expression of VEGF-D in colorectal tumours is significantly associated with lymphatic involvement in CRC patients and such expression might be blocked effectively by cetuximab.
文摘Objective:The aim of the study was to observe the efficacies of 89Sr and combination treatments with regional extra-beam radiotherapy for cancer patients with multiple bone metastasis.Methods:A total of 106 patients were divided into two groups, and each group were 53 patients:the simple 89Sr treatment group (simple group), and local radiotherapy and 89Sr treatment group (combination group).The dose of 4 mci of 89Sr was made in every patient by intravenous injection, 6 MV linear accelerator external irradiation dose was given 30-60 Gy/2-4 weeks.Results:The effective rates of simple and combination groups were respectively 83.01% and 90.56%; the effective improvement rates of the bone focus of two groups were 75.48% and 86.8%, respectively.There was homologous improvement in general conditions.Conclusion:89Sr treatment has a certain effect to the cancers of whole-body multiple bone metastases.And the combined treatment with regional radiotherapy can improve the efficacy and life quality of cancer patients with bone metastasis.
文摘This paper proposes a new type of pulse launcher that applies the principle of linear motors. The stator, viz. gun barrel, of the launcher has a new structure of one segment of iron core consisting of 3 staggered laminations. This structure is helpful in advancing the thrust force per volume. Based on introducing the structure and the working principles, this paper resolves the electromagnetic thrusting force and performs mechanical analysis and experiments on the sample launcher. The research shows that this launcher is simple and brushless structure with brief controlling.
文摘The dosimetric inter-comparison studies carry pertinent significance to ensure uniform radiation dose delivery for clinical trials. This paper investigates the comparative performance analysis of an X-ray high power linear accelerator per- formed by the International Dosimetry Survey Mission and Institute of Nuclear Medicine ＆ Oncology （INMOL）, Lahore. The measurements were made using cylindrical ionization chambers based on the International Atomic Energy Agency （IAEA） TRS-398 protocol for absorbed dose-to-water dosimetric standards, and the percentage deviation was found to be between 0.5 % - 1%. The dosimetric analysis concerning linear X-ray accelerator output performed by INMOL, Lahore was found to be in good agreement with the results of IAEA Dosimtery Survey Mission.
文摘Objective:The aim of this study was to measure the leakage by two methods with ion chamber and ready packs film,and to investigate the feasibility and the advantages of using two dosimetry methods for assessing leakage radiation around the head of the linear accelerators.Methods:Measurements were performed using a 30 cm3ion chamber;the gantry at 0°,the X-ray head at 0°,the field size at between the central axis and a plane surface at a FSD of 100 as a reference,a series of concentric circles having radii of 50,75,and 100 cm with their common centre at the reference point.The absorbed dose was measured at the reference point,and this would be used as the reference dose.With the diaphragm closed,the measurements were taken along the circumference of the three circles and at 45°intervals.Results:Leakage radiations while the treatment head was in the vertical position varied between 0.016%–0.04%.With the head lying horizontally,leakage radiation was the same order magnitude and varied between 0.02%–0.07%.In the second method,the verification was accomplished by closing the collimator jaws and covering the head of the treatment unit with the ready pack films.The films were marked to permit the determination of their positions on the machine after exposed and processed.With the diaphragm closed,and the ready packs films around the linear accelerator the beam turned on for 2500 cGy(2500 MU).The optical density of these films was measured and compared with this of the reference dose.Leakage radiation varied according to the film positions and the magnitude of leakage was between 0.005%–0.075%.Conclusion:The differences between the values of the leakage radiation levels observed at different measurement points do not only reflect differences in the effective shielding thickness of the head wall,but are also related to differences in the distances between the target and the measurement points.The experimental errors involved in dosimetric measurement also contribute to such differences.
基金Project(2011BAE22B05)supported by the National Science and Technology Pillar Program during the 12th Five-year Plan of China
文摘Combustion noise takes large proportion in diesel engine noise and the studies of its influence factors play an important role in noise reduction. Engine noise and cylinder pressure measurement experiments were carried out. And the improved attenuation curves were obtained, by which the engine noise was predicted. The effect of fuel injection parameters in combustion noise was investigated during the combustion process. At last, the method combining single variable optimization and multivariate combination was introduced to online optimize the combustion noise. The results show that injection parameters can affect the cylinder pressure rise rate and heat release rate, and consequently affect the cylinder pressure load and pressure oscillation to influence the combustion noise. Among these parameters, main injection advance angle has the greatest influence on the combustion noise, while the pilot injection interval time takes the second place, and the pilot injection quantity is of minimal impact. After the optimal design of the combustion noise, the average sound pressure level of the engine is distinctly reduced by 1.0 d B(A) generally. Meanwhile, the power, emission and economy performances are ensured.
