目的:观察益肾通络督脉灸对特发性弱精子不育症患者精子质量及功能的影响。方法:将120例特发性弱精子不育症患者,按照随机数字表法分为对照组和治疗组,每组60例。研究期间,对照组病例脱落、失访4例,完成56例;治疗组病例失访、脱落2例,完...目的:观察益肾通络督脉灸对特发性弱精子不育症患者精子质量及功能的影响。方法:将120例特发性弱精子不育症患者,按照随机数字表法分为对照组和治疗组,每组60例。研究期间,对照组病例脱落、失访4例,完成56例;治疗组病例失访、脱落2例,完成58例。对照组给予右归胶囊口服治疗,治疗组在对照组治疗的基础上给予益肾通络督脉灸治疗。记录治疗前后前向运动精子百分率(percentage of forward motile sperm,PR)、精子总活力[PR+非前向运动精子百分率]、精子直线运动速度、精子DNA碎片指数(sperm DNA fragmentation index,DFI)。结果:治疗组有效率为89.66%,对照组有效率为71.43%,治疗组有效率高于对照组,差异有统计学意义(P<0.05);治疗组治疗后PR、精子总活力、精子直线运动速度、DFI均高于对照组,差异有统计学意义(P<0.05)。结论:益肾通络督脉灸治疗特发性弱精子不育症,可明显改善前向运动精子百分率、精子总活力、精子直线运动速度、精子DNA碎片指数。展开更多
A novel method of matching stiffness and continuous variable damping of an ECAS(electronically controlled air suspension) based on LQG(linear quadratic Gaussian) control was proposed to simultaneously improve the road...A novel method of matching stiffness and continuous variable damping of an ECAS(electronically controlled air suspension) based on LQG(linear quadratic Gaussian) control was proposed to simultaneously improve the road-friendliness and ride comfort of a two-axle school bus.Taking account of the suspension nonlinearities and target-height-dependent variation in suspension characteristics,a stiffness model of the ECAS mounted on the drive axle of the bus was developed based on thermodynamics and the key parameters were obtained through field tests.By determining the proper range of the target height for the ECAS of the fully-loaded bus based on the design requirements of vehicle body bounce frequency,the control algorithm of the target suspension height(i.e.,stiffness) was derived according to driving speed and road roughness.Taking account of the nonlinearities of a continuous variable semi-active damper,the damping force was obtained through the subtraction of the air spring force from the optimum integrated suspension force,which was calculated based on LQG control.Finally,a GA(genetic algorithm)-based matching method between stepped variable damping and stiffness was employed as a benchmark to evaluate the effectiveness of the LQG-based matching method.Simulation results indicate that compared with the GA-based matching method,both dynamic tire force and vehicle body vertical acceleration responses are markedly reduced around the vehicle body bounce frequency employing the LQG-based matching method,with peak values of the dynamic tire force PSD(power spectral density) decreased by 73.6%,60.8% and 71.9% in the three cases,and corresponding reduction are 71.3%,59.4% and 68.2% for the vehicle body vertical acceleration.A strong robustness to variation of driving speed and road roughness is also observed for the LQG-based matching method.展开更多
文摘目的:观察益肾通络督脉灸对特发性弱精子不育症患者精子质量及功能的影响。方法:将120例特发性弱精子不育症患者,按照随机数字表法分为对照组和治疗组,每组60例。研究期间,对照组病例脱落、失访4例,完成56例;治疗组病例失访、脱落2例,完成58例。对照组给予右归胶囊口服治疗,治疗组在对照组治疗的基础上给予益肾通络督脉灸治疗。记录治疗前后前向运动精子百分率(percentage of forward motile sperm,PR)、精子总活力[PR+非前向运动精子百分率]、精子直线运动速度、精子DNA碎片指数(sperm DNA fragmentation index,DFI)。结果:治疗组有效率为89.66%,对照组有效率为71.43%,治疗组有效率高于对照组,差异有统计学意义(P<0.05);治疗组治疗后PR、精子总活力、精子直线运动速度、DFI均高于对照组,差异有统计学意义(P<0.05)。结论:益肾通络督脉灸治疗特发性弱精子不育症,可明显改善前向运动精子百分率、精子总活力、精子直线运动速度、精子DNA碎片指数。
基金Projects(51305117,51178158)supported by the National Natural Science Foundation of ChinaProject(20130111120031)supported by the Specialized Research Fund for the Doctoral Program of Higher Education+1 种基金Project(2013M530230)supported by the China Postdoctoral Science FoundationProjects(2012HGQC0015,2011HGBZ0945)supported by the Fundamental Research Funds for the Central Universities,China
文摘A novel method of matching stiffness and continuous variable damping of an ECAS(electronically controlled air suspension) based on LQG(linear quadratic Gaussian) control was proposed to simultaneously improve the road-friendliness and ride comfort of a two-axle school bus.Taking account of the suspension nonlinearities and target-height-dependent variation in suspension characteristics,a stiffness model of the ECAS mounted on the drive axle of the bus was developed based on thermodynamics and the key parameters were obtained through field tests.By determining the proper range of the target height for the ECAS of the fully-loaded bus based on the design requirements of vehicle body bounce frequency,the control algorithm of the target suspension height(i.e.,stiffness) was derived according to driving speed and road roughness.Taking account of the nonlinearities of a continuous variable semi-active damper,the damping force was obtained through the subtraction of the air spring force from the optimum integrated suspension force,which was calculated based on LQG control.Finally,a GA(genetic algorithm)-based matching method between stepped variable damping and stiffness was employed as a benchmark to evaluate the effectiveness of the LQG-based matching method.Simulation results indicate that compared with the GA-based matching method,both dynamic tire force and vehicle body vertical acceleration responses are markedly reduced around the vehicle body bounce frequency employing the LQG-based matching method,with peak values of the dynamic tire force PSD(power spectral density) decreased by 73.6%,60.8% and 71.9% in the three cases,and corresponding reduction are 71.3%,59.4% and 68.2% for the vehicle body vertical acceleration.A strong robustness to variation of driving speed and road roughness is also observed for the LQG-based matching method.
