论铁路企业风险评估与隐患排查的相互应用

为探索隐患排查与风险评估结果互相应用的模式,通过梳理隐患排查与风险评估知识,在理论研究的基础上,探讨如何建立风险管控与隐患排查工作结果的运用机制,将风险评估结果应用于建立隐患排查清单的工作当中,再将隐患排查结果应用于风险评估过程中;并通过某铁路公司单月安全管控情况验证研究方式的有效性。研究结果表明:通过采用隐患排查结果作为评估数据可以使评估结论与隐患排查范围紧密结合,使得评估结论可以指导隐患排查工作重点,从而提升隐患排查效率。采用周期内实际存在的不同类别的隐患问题数量比值代替专家打分,使风险评价工作更加客观,符合现场安全生产实际情况。

在医院财务管理中会计和统计的相互应用思路构建

近年来,我国市场机制在不断的发展完善,随之也带动了医疗卫生事业的发展。我国医疗卫生事业在发展的同时,也暴露了一系列的问题,医院财务管理方面的问题又日益突出,对我国医疗卫生事业的发展造成了一定的影响。对于医院而言,财务管理是一项重要工作,同时也对医院的正常运转有着一定的影响。作为医院经济管理的重要内容,会计与统计与医院财务管理有着密切的联系。文章针对医院财务管理中会计与统计的相关应用进行了研究。

财务会计与管理会计的融合应用诉求与相互发展

本文针对财务会计与管理会计的应用诉求和相互发展，主要从财务会计与管理会计融合的应用诉求、我国当前财务会计与管理会计融合的现状、财务会计与管理会计融合的相互发展与实施路径三个方面进行了一定的研究与探讨，且对财务会计与管理会计进行有机融合会遇到的困难与解决办法进行了探讨，最终提出了其创新发展的一些可行措施。

计算机平面设计中设计软件的相互结合应用分析

在现代设计技术的构成内容中,计算机平面设计属于其中内容之一,居于至关重要的地位。在计算机平面设计中,主要对所有设计软件开展运用活动,进而对优秀的平面设计作品做出获取。文章主要分析了计算机软件与平面设计结合的优势,提出了计算机平面设计中设计软件的分类分析,制定了计算机平面设计中设计软件的相互结合应用。

在医院财务管理中会计和统计的互相应用

医院的财务管理，随着医院系统的不断发展壮大和内部财务复杂性的提高，对财会人员提出了越来越高的要求。让我们的财会人员在提高自身专业技能的基础上，还需要不断地汲取其他的科学理论，采用其他的科学方法，以满足医院财务管理的需求。统计作为一种常用的以数字为基础的学科被越来越多的应用到医院的财务管理中，并发挥重要作用。文章简要分析了会计与统计在医院财务管理中的应用，并说明了它们之间的相互作用，说明了会计与统计相互作用的重要性。

Zonal Coupling Analysis Method of Seismic Response of Offshore Monopile Wind Turbine

The seismic safety of offshore wind turbines is an important issue that needs to be solved urgently.Based on a unified computing framework,this paper develops a set of seawater-seabed-wind turbine zoning coupling analysis methods.A 5 MW wind turbine and a site analysis model are established,and a seismic wave is selected to analyze the changes in the seismic response of offshore monopile wind turbines under the change of seawater depth,seabed wave velocity and seismic wave incidence angle.The analysis results show that when the seawater increases to a certain depth,the seismic response of the wind turbine increases.The shear wave velocity of the seabed affects the bending moment and displacement at the bottom of the tower.When the angle of incidence increases,the vertical displacement and the acceleration of the top of the tower increase in varying degrees.

ITS技术在军事物流中的应用

笔者首先,介绍了ITS技术的概念;然后,分别从提供实时交通信息、提供车辆监控可视化信息、为驾驶员提供安全保证信息、增强军事供应链四个方面阐述了ITS技术在现代化军事物流系统中运行的作用;最后,结合作用又从ITS和现代化军事物流协同发展、构建ITS和现代化军事物流共同信息平台、建立合作共赢的关系三点提出了ITS技术在现代化军事物流运行和实施过程中应注意的一些问题。

软件技术在工程领域的应用优势分析

随着现代社会的迅速发展,科学技术水平也是越来越高,计算机软件技术也得到了十足的发展,软件技术的更新更是也日新月异。现代社会的发展离不开软件技术的发展,其已经渗透到了人们生活的方方面面,尤其是在工程领域,其有着不可替代的作用。本文就主要不对工程项目进行了简单介绍,分析了软件技术在工程领域的应用优势所在。

慕课形式与小学数学教学的融合应用

从1949年建国以来,中国先后经历了八次教育体制改革,在这些改革的其间,基础教育也的内容和形式也在发生着重要的改变,以课堂教育为核心教育的体制,正在对整个教学的软环境,发生着积极的改变。社会的教育类型正在发生着系统的改革。小学数学教学是承上启下的特殊阶段,是对于小学知识的总结,为小学数学学习打下扎实的基础,为初中做好充足的知识储备。慕课教育是近年来小学数学教学中经常用到的授课形式,教学内容通过慕课视频,以一种生动而形象的形式将教学重点内容展现出来,对小学数学的学习效果有一个质的改善。通过慕课形式与小学数学教学的融合应用,使整个小学数学的教学课堂变得更加生动化、多样化,从而令学生喜欢上数学这门课程。

Evidence That the Auxin Signaling Pathway Interacts with Plant Stress Response

Auxin influences a variety of developmental and physiological processes. Early reports, suggested that auxin might affect plant stress response. We have identified a number of auxin responsive genes in Arabidopsis thaliana (L.) Heynh. by using cDNA an-ay and found that stress responsive genes, such as,Arabidopsis homolog of MEK kinase 1 (ATMEKK1), ReL/SpoT homolog 3 ( At-RSH3), Catalase 1 ( Cat1) and Ferritin 1 (Fer1), were down-regulated by auxin, indicating that auxin regulates ale expression of stress responsive genes. We also demonstrated that nitrilase genes, nitrilase I ( NIT]) and nitrilase 2 (NIT2) involving in indole-3-acetic acid (IAA) biosynthesis, were induced by salinity stress, suggesting that the level of IAA might increase in response to salinity stress. To dissect the signal pathway involved in the interaction, two auxin insensitive mutants, auxin resistant 2 (axr2) and auxin resistant 1-3 (axrl-3) were used. Stress responsive genes were induced by salt stress in wild type and axr2, but not in axr1-3. The result suggests that die interaction between auxin and stress responses may be linked in the ubiquitin pathway.

Zinc finger E-box-binding homeobox 1 mediates aerobic glycolysis via suppression of sirtuin 3 in pancreatic cancer

AIM TO uncover the roles of tumor-promoting gene ZEB1 in aerobic glycolysis regulation and shed light on the underlying molecular mechanism.METHODS Endogenous zinc finger E-box binding homeobox-1 （ZEB1） was silenced using a and the impact of ZEB1 and lentivirus-mediated method, methyI-CpG binding domain protein 1 （MBD1） on aerobic glycolysis was measured using seahorse cellular flux analyzers, reactive oxygen species quantification, and mitochondrial membrane potential measurement. The interaction between ZEB1 and MBD1 was assessed by co-immunoprecipitation and immunofluorescence assays. The impact of ZEB1 and MBD1 interaction on sirtuin 3 （SIRT3） expression was confirmed by quantitative polymerase chain reaction, western blotting, and dual-luciferase and chromatinimmunoprecipitation assays.RESULTS ZEB1 was a positive regulator of aerobic glycolysis in pancreatic cancer. ZEB1 transcriptionally silenced expression of SIRT3, a mitochondrial-localized tumor suppressor, through interaction with MBD1.CONCLUSION ZEB1 silenced SIRT3 expression via interaction with MBD1 to promote aerobic glycolysis in pancreatic cancer.

Effects of Anisotropy on Entanglement in a Two-Qubit Heisenberg XYZ Chain with Intrinsic Decoherence

Taking the intrinsic decoherence effect into account, the entanglement ofa two-qubit anisotropic Heisenberg XYZ chain in the presence of the Dzyaloshinski Moriya （DM） anisotropic antisymetric interaction is investigated in this paper. Concurrence, the measurement of entanglement, is calculated. Compared with the anisotropic in XY plane, the DM interaction is another kind of anisotropic antisymmetrie exchange interaction. It is shown that the intrinsic decoherence obviously suppresses the time evolution of the entanglement. The DM interaction only acts on the time evolution of the entanglement when the initial state is [ψ（0）〉 = cosα｜01〉 ＋ sinα｜10〉 and weakens the degree of entanglement. The anisotropic in XY plane merely impacts on the time evolution of the entanglement when the system ＆ initially in a state ｜ψ（0）〉 = cos α｜00〉 ＋ sin α｜11 〉. The sufficiently weak anisotropic in XY plane can effectively enhance the degree of entanglement.

Computation of Ship Hydrodynamic Interaction Forces in Restricted Waters using Potential Theory

A computer code based on the double-body potential flow model and the classic source panel method has been developed to study various problems of hydrodynamic interaction between ships and other objects with solid boundaries including the seabed. A peculiarity of the proposed implementation is the application of the so-called ＂moving-patch＂ method for simulating steady boundaries of large extensions. The method is based on an assumption that at any moment just the part of the boundary （＂moving patch＂） which lies close to the interacting ship is significant for the near-field interaction. For a specific case of the fiat bottom, comparative computations were performed to determine optimal dimensions of the patch and of the constituting panels based on the trade-off between acceptable accuracy and reasonable efficiency. The method was applied to estimate the sway force on a ship hull moving obliquely across a dredged channel. The method was validated for a case of ship-to-ship interaction when tank data were available. This study also contains a description of a newly developed spline approximation algorithm necessary for creating consistent discretizations of ship hulls with various degrees of refinement.

Interplay between hepatitis B virus and the innate immune responses:implications for new therapeutic strategies

Hepatitis B virus(HBV) infection is still a worldwide health problem;however,the current antiviral therapies for chronic hepatitis B are limited in efficacy.The outcome of HBV infection is thought to be the result of complex interactions between the HBV and the host immune system.While the role of the adaptive immune responses in the resolution of HBV infection has been well characterized,the contribution of innate immune mechanisms remains elusive until recent evidence implicates that HBV appears to activate the innate immune response and this response is important for controlling HBV infection.Here,we review our current understanding of innate immune responses to HBV infection and the multifaceted evasion by the virus and discuss the potential strategies to combat chronic HBV infection via induction and restoration of host innate antiviral responses.

Complement and its role in innate and adaptive immune responses

The complement system plays a crucial role in the innate defense against common pathogens. Activation of complement leads to robust and efficient proteolytic cascades, which terminate in opsonization and lysis of the pathogen as well as in the generation of the classical inflammatory response through the production of potent proinflammatory molecules. More recently, however, the role of complement in the immune response has been expanded due to observations that link complement activation to adaptive immune responses. It is now appreciated that complement is a functional bridge between innate and adaptive immune responses that allows an integrated host defense to pathogenic challenges. As such, a study of its functions allows insight into the molecular underpinnings of host-pathogen interactions as well as the organization and orchestration of the host immune response. This review attempts to summarize the roles that complement plays in both innate and adaptive immune responses and the consequences of these interactions on host defense.

Beam-track interaction of high-speed railway bridge with ballast track

Based on the construction bridge of Xiamen-Shenzhen high-speed railway(9-32 m simply-supported beam + 6×32 m continuous beam),the pier-beam-track finite element model,where the continuous beam of the ballast track and simply-supported beam are combined with each other,was established.The laws of the track stress,the pier longitudinal stress and the beam-track relative displacement were analyzed.The results show that reducing the longitudinal resistance can effectively reduce the track stress and the pier stress of the continuous beam,and increase the beam-track relative displacement.Increasing the rigid pier stiffness of continuous beam can reduce the track braking stress,increase the pier longitudinal stress and reduce the beam-track relative displacement,Increasing the rigid pier stiffness of simply-supported beam can reduce the track braking stress,the rigid pier longitudinal stress and the beam-track relative displacement.

Protein interaction network related to Helicobacter pylori infection response

AIM:To understand the complex reaction of gastric inflammation induced by Helicobacter pylori(H pylori) in a systematic manner using a protein interaction network. METHODS:The expression of genes significantly changed on microarray during H pylori infection was scanned from the web literary database and translated into proteins.A network of protein interactions was constructed by searching the primary interactions of selected proteins.The constructed network was mathematically analyzed and its biological function was examined.In addition,the nodes on the network were checked to determine if they had any further functional importance or relation to other proteins by extending them. RESULTS:The scale-free network showing the relationship between inflammation and carcinogenesis was constructed.Mathematical analysis showed hub and bottleneck proteins,and these proteins were mostly related to immune response.The network contained pathways and proteins related to H pylori infection,such as the JAK-STAT pathway triggered by interleukins.Activation of nuclear factor (NF)-κB,TLR4,and other proteins known to function as core proteins of immune response were also found. These immune-related proteins interacted on the network with pathways and proteins related to the cell cycle,cell maintenance and proliferation,andtranscription regulators such as BRCA1,FOS,REL,and zinc finger proteins.The extension of nodes showed interactions of the immune proteins with cancer- related proteins.One extended network,the core network,a summarized form of the extended network, and cell pathway model were constructed. CONCLUSION:Immune-related proteins activated by H pylori infection interact with proto-oncogene proteins.The hub and bottleneck proteins are potential drug targets for gastric inflammation and cancer.

Potassium Fractions in Soils as Affected by Monocalcium Phosphate,Ammonium Sulfate,and Potassium Chloride Application

Soil potassium （K） deficiency has been increasing over recent decades as a result of higher inputs of N and P fertilizers concomitant with lower inputs of K fertilizers in China; however, the effects of interactions between N, P, and K of fertilizers on K status in soils have not been thoroughly investigated for optimizing N, P, and K fertilizer use efficiency. The influence of ammonium sulfate （AS）, monocMcium phosphate （MCP）, and potassium chloride application on K fractions in three typical soils of China was evaluated during 90-d laboratory soil incubation. The presence of AS significantly altered the distribution of native and added K in soils, while addition of MCP did not significantly affected K equilibrium in most cases. Addition of AS significantly increased water-soluble K （WSK）, decreased exchangeable K （EK） in almost all the soils except the paddy soil that contained considerable amounts of 2：1 type clay minerals with K added, retarded the formation of fixed K in the soils with K added, and suppressed the release of fixed K in the three soils without K added. These interactions might be expected to influence the K availability to plants when the soil was fertilized with AS. To improve K fertilizer use efficiency, whether combined application of AS and K was to be recommended or avoided should depend on K status of the soil, soil properties, and cropping systems.

Interaction of a circular cavity and a beeline crack in right-angle plane impacted by SH-wave

The problem of scattering of SH-wave by a circular cavity and an arbitrary beeline crack in right-angle plane was investigated using the methods of Green's function,complex variables and muti-polar coordinates.Firstly,we constructed a suitable Green's function,which is an essential solution to the displacement field for the elastic right-angle plane possessing a circular cavity while bearing out-of-plane harmonic line source load at arbitrary point.Secondly,based on the method of crack-division,integration for solution was established,then expressions of displacement and stress were obtained while crack and circular cavities were both in existence.Finally,the dynamic stress concentration factor around the circular cavity and the dynamic stress intensity factor at crack tip were discussed to the cases of different parameters in numerical examples.Calculation results show that the crack produces adverse engineering influence on both of the dynamic stress concentration factor and the dynamic stress intensity factor.

Effect of interaction of dislocations with core-shell nanowires on critical shear stress of nanocomposites

The contribution to the critical shear stress of nanocomposites caused by the interaction between screw dislocations and core-shell nanowires (coated nanowires) with interface stresses was derived by means of the MOTT and NABARRO's model. The influence of interface stresses on the critical shear stress was examined. The result indicates that, if the volume fraction of the core-shell nanowires keeps a constant, an optimal critical shear stress may be obtained when the radius of the nanowire with interface stresses reaches a critical value, which differs from the classical solution without considering the interface stresses under the same external conditions. In addition, the material may be strengthened by the soft nanowires when the interface stresses are considered. There also exist critical values of the elastic modulus and the thickness of surface coating to alter the strengthening effect produced by it.