For many clustering algorithms,it is very important to determine an appropriate number of clusters,which is called cluster validity problem.In this paper,a new clustering validity assessment index is proposed based on...For many clustering algorithms,it is very important to determine an appropriate number of clusters,which is called cluster validity problem.In this paper,a new clustering validity assessment index is proposed based on a novel method to select the margin point between two clusters for in-ter-cluster similarity more accurately,and provides an improved scatter function for intra-cluster similarity.Simulation results show the effectiveness of the proposed index on the data sets under consideration regardless of the choice of a clustering algorithm.展开更多
In this paper,we study the problem of privacy-preserving top-k keyword similarity search over outsourced cloud data.Taking edit distance as a measure of similarity,we first build up the similarity keyword sets for all...In this paper,we study the problem of privacy-preserving top-k keyword similarity search over outsourced cloud data.Taking edit distance as a measure of similarity,we first build up the similarity keyword sets for all the keywords in the data collection.We then calculate the relevance scores of the elements in the similarity keyword sets by the widely used tf-idf theory.Leveraging both the similarity keyword sets and the relevance scores,we present a new secure and efficient treebased index structure for privacy-preserving top-k keyword similarity search.To prevent potential statistical attacks,we also introduce a two-server model to separate the association between the index structure and the data collection in cloud servers.Thorough analysis is given on the validity of search functionality and formal security proofs are presented for the privacy guarantee of our solution.Experimental results on real-world data sets further demonstrate the availability and efficiency of our solution.展开更多
AIM To evaluate the inflammatory state in Crohn's disease(CD) patients and correlate it with genetic background and microbial spreading.METHODS By means of flow cytometry, production of tumor necrosis factor-alpha...AIM To evaluate the inflammatory state in Crohn's disease(CD) patients and correlate it with genetic background and microbial spreading.METHODS By means of flow cytometry, production of tumor necrosis factor-alpha(TNF-α) was measured in peripheral blood monocytes from patients suffering from CD, ulcerative colitis(UC) and in healthy subjects after stimulation of the NOD2 and TLR pathways. CD patients were genotyped for the three most common NOD2 variants(R702W, G908 R and L1007Pfs*2) and basal production of TNF-α was correlated to NOD2 genotype. Also, production of TNF-α was correlated to plasmatic levels of LPS Binding Protein(LBP), soluble(s) CD14 and to the activity state of the disease.RESULTS The patients with CD were characterized by a significantly higher monocyte basal expression of TNF-αcompared with healthy subjects and UC patients, and after stimulation with Pam3CSK4(ligand of TLR2/1) and MDP-L18(ligand of NOD2) this difference was maintained, while other microbial stimuli(LPS, ligand of TLR4 and Poly I:C, ligand of TLR3) induced massive activation in CD monocytes as well as in UC and in healthy control cells. There was no significant difference in the production of TNF- α between patients who carried CD-associated heterozygous or homozygous variants in NOD2 and patients with wild type NOD2 genotype. Although serum LBP levels have been shown to correlate positively with the state of activity of the disease, TNF-α production did not show a clear correlation with either LBP or s CD14 levels in plasma. Moreover, no clear correlation was seen between TNF-α production and activity indices in either CD or UC.CONCLUSION Peripheral monocytes from CD express higher basal and stimulated TNF-α than controls, regardless of NOD2 genotype and without a clear correlation with disease activity.展开更多
文摘For many clustering algorithms,it is very important to determine an appropriate number of clusters,which is called cluster validity problem.In this paper,a new clustering validity assessment index is proposed based on a novel method to select the margin point between two clusters for in-ter-cluster similarity more accurately,and provides an improved scatter function for intra-cluster similarity.Simulation results show the effectiveness of the proposed index on the data sets under consideration regardless of the choice of a clustering algorithm.
基金supported partly by the following funding agencies:the National Natural Science Foundation(No.61170274)the Innovative Research Groups of the National Natural Science Foundation(No.61121061)+1 种基金the National Key Basic Research Program of China (No.2011CB302506)Youth Scientific Research and Innovation Plan of Beijing University of Posts and Telecommunications(No. 2013RC1101)
文摘In this paper,we study the problem of privacy-preserving top-k keyword similarity search over outsourced cloud data.Taking edit distance as a measure of similarity,we first build up the similarity keyword sets for all the keywords in the data collection.We then calculate the relevance scores of the elements in the similarity keyword sets by the widely used tf-idf theory.Leveraging both the similarity keyword sets and the relevance scores,we present a new secure and efficient treebased index structure for privacy-preserving top-k keyword similarity search.To prevent potential statistical attacks,we also introduce a two-server model to separate the association between the index structure and the data collection in cloud servers.Thorough analysis is given on the validity of search functionality and formal security proofs are presented for the privacy guarantee of our solution.Experimental results on real-world data sets further demonstrate the availability and efficiency of our solution.
基金Supported by Institute for Maternal and Child Health,IRCCS"Burlo Garofolo",No.RC 03/2009
文摘AIM To evaluate the inflammatory state in Crohn's disease(CD) patients and correlate it with genetic background and microbial spreading.METHODS By means of flow cytometry, production of tumor necrosis factor-alpha(TNF-α) was measured in peripheral blood monocytes from patients suffering from CD, ulcerative colitis(UC) and in healthy subjects after stimulation of the NOD2 and TLR pathways. CD patients were genotyped for the three most common NOD2 variants(R702W, G908 R and L1007Pfs*2) and basal production of TNF-α was correlated to NOD2 genotype. Also, production of TNF-α was correlated to plasmatic levels of LPS Binding Protein(LBP), soluble(s) CD14 and to the activity state of the disease.RESULTS The patients with CD were characterized by a significantly higher monocyte basal expression of TNF-αcompared with healthy subjects and UC patients, and after stimulation with Pam3CSK4(ligand of TLR2/1) and MDP-L18(ligand of NOD2) this difference was maintained, while other microbial stimuli(LPS, ligand of TLR4 and Poly I:C, ligand of TLR3) induced massive activation in CD monocytes as well as in UC and in healthy control cells. There was no significant difference in the production of TNF- α between patients who carried CD-associated heterozygous or homozygous variants in NOD2 and patients with wild type NOD2 genotype. Although serum LBP levels have been shown to correlate positively with the state of activity of the disease, TNF-α production did not show a clear correlation with either LBP or s CD14 levels in plasma. Moreover, no clear correlation was seen between TNF-α production and activity indices in either CD or UC.CONCLUSION Peripheral monocytes from CD express higher basal and stimulated TNF-α than controls, regardless of NOD2 genotype and without a clear correlation with disease activity.
