血浆IL-8是新生儿早期细菌感染(EOBI)的早期诊断指标,但是其半衰期较短。而净化剂溶解的全血(DLWB)IL-8既包括细胞外IL-8,也包括细胞结合型IL-8。此目的是研究健康新生儿和怀疑EOBI新生儿的血浆和DLWB中IL-8的代谢动力学,进而检证DLWB ...血浆IL-8是新生儿早期细菌感染(EOBI)的早期诊断指标,但是其半衰期较短。而净化剂溶解的全血(DLWB)IL-8既包括细胞外IL-8,也包括细胞结合型IL-8。此目的是研究健康新生儿和怀疑EOBI新生儿的血浆和DLWB中IL-8的代谢动力学,进而检证DLWB 中IL-8浓度测定对诊断EOBI具有更高的敏感性这一假想。研究组包括了61例具有EOBI临床或血清学征象的新生儿;188例具有感染风险因素但没有EOBI的新生儿编入对照组。测定血浆和DLWB中IL-8的浓度。在对照组中,新生儿直到出生后24 h内DLWB中IL-8浓度比相应的血浆IL-8浓度(34.2 ng/L,s= 18.1)升高了280倍(9 599 ng/L,s=4 433)。DLWB中IL-8浓度对EOBI的敏感度与血浆相比,出生6 h后是0.97 vs 0.71,出生24 h后是0.70 vs 0.32。两者的特异性相应值相比,出生6 h后是0.95 vs 0.90,出生24 h 后是0.92 vs 0.99。出生24 h后,DLWB中IL-8EOBI 阴性预测值与血浆IL-8相比是0.80 vs 0.66。结果显示DLWB中IL-8在临床怀疑EOBI最初6 h内比血浆中IL-8具有较高的敏感性。而且其增高能保持较长时间。笔者认为检测DLWB中IL-8的水平对EOBI的诊断具有较高的敏感性。展开更多
Our objective was to compare the blood pressure of 20- y-old very low birth weight (VLBW; < 1.5 kg) individuals with that of normal birth weight (NBW) control individuals. The population included 195 VLBW (92 femal...Our objective was to compare the blood pressure of 20- y-old very low birth weight (VLBW; < 1.5 kg) individuals with that of normal birth weight (NBW) control individuals. The population included 195 VLBW (92 female and 103 male) and 208 NBW (107 female and 101 male) individuals who were born between 1977 and 1979. Independent effects of birth weight status (VLBW versus NBW) and within the VLBW cohort of intrauterine growth (birth weight z score) were examined via multiple regression analyses. VLBW individuals had a higher mean systolic blood pressure (SBP) than NBW control individuals (114 ± 11 versus 112± 13 mm Hg). SBP for VLBW female infants was 110± 9 versus NBW 107± 12 and for VLBW male individuals was 118± 11 versus NBW 117± 11 mm Hg. After adjustment for gender, race, and maternal education, the difference in SBP between VLBW and NBW individuals was 1.9 mm Hg but was 3.5 mm after also adjustment for later size (20- y weight and height z scores), which reflects catch-up growth. For female individuals, the difference in SBP between VLBW and NBW individuals was significant both unadjusted and adjusted for later size, whereas for male individuals, the differencewas significant only after adjustment for later size. Intrauterine growth did not have a significant effect on SBP within the VLBW group, even after adjustment for later size. VLBW individuals, specifically female individuals, have a higher SBP than NBW control individuals. This is not explained by intrauterine growth failure.展开更多
On the basis of mutual compensation of mobility and threshold voltage temperature effects, a stable CMOS band-gap voltage reference circuit was designed and fabricated in CSMC-HJ 0.6 μm CMOS technology. Operating fro...On the basis of mutual compensation of mobility and threshold voltage temperature effects, a stable CMOS band-gap voltage reference circuit was designed and fabricated in CSMC-HJ 0.6 μm CMOS technology. Operating from 0 to 85 ℃ under a supply voltage ranging from 4.5 to 5.5 V, the voltage reference circuit offers an output reference voltage ranging from 1.122 to 1.176 V and a voltage variation less than ±3.70%. The chip size including bonding pads is only 0.4 mm×0.4 mm and the power dissipation falls inside the scope of 28.3 to 48.8 mW operating at a supply voltage of 4.5 to 5.5 V.展开更多
The Reynolds stress transport model and the Eulerian two-fluid model provided by the FLUENT code were applied to evaluate the gas-particle two-phase flow in the ceramic filter vessel. The ceramic filter vessel contain...The Reynolds stress transport model and the Eulerian two-fluid model provided by the FLUENT code were applied to evaluate the gas-particle two-phase flow in the ceramic filter vessel. The ceramic filter vessel contains six candle filters, which are arranged in the form of equilateral hexagon. The variation of the areal density of the filter cake during the filtration and the back-pulse process were analyzed. The coupling effect between filters, gas and solid, filtration and pulse cleaning process were investigated, respectively. The numerical results show a good approach to predict the particle distribution in the vessel and the particle deposition on the filter element. This study provides the base for the intensive study on the analysis of the gas-particle flow in the filter vessel.展开更多
Foreground detection is a fundamental step in visual surveillance.However,accurate foreground detection is still a challenging task especially in dynamic backgrounds.In this paper,we present a nonparametric approach t...Foreground detection is a fundamental step in visual surveillance.However,accurate foreground detection is still a challenging task especially in dynamic backgrounds.In this paper,we present a nonparametric approach to foreground detection in dynamic backgrounds.It uses a history of recently pixel values to estimate background model.Besides,the adaptive threshold and spatial coherence are introduced to enhance robustness against false detections.Experimental results indicate that our approach achieves better performance in dynamic backgrounds compared with several approaches.展开更多
AIM:To investigate the diagnostic value of glypican-3(GPC3) and its relationship with hepatocellular carcinoma(HCC) recurrence after liver transplantation.METHODS:HCC tissue samples(n = 31) obtained from patients who ...AIM:To investigate the diagnostic value of glypican-3(GPC3) and its relationship with hepatocellular carcinoma(HCC) recurrence after liver transplantation.METHODS:HCC tissue samples(n = 31) obtained from patients who had undergone liver transplantation were analyzed.GPC3 mRNA and protein expression were analyzed by TaqMan real-time reverse transcription-polymerase chain reaction and immunohistochemistry.Correlation between the GPC3 expression and clinicopathological features was analyzed.The potential prognostic value of GPC3 was investigated by comparing recurrence-free survival between HCC patients with and without GPC3 expression.RESULTS:Using a cutoff value of 3.5 × 10-2,20 of 31 cancerous tissues had expression values of > 3.5 × 10-2,whereas 3 of 31 adjacent non-neoplastic parenchyma and 0 of 20 control liver tissues had expression values of > 3.5 × 10-2(P < 0.001).GPC3 protein was immunoexpressed in 68% of cancerous tissues,but not in adjacent non-neoplastic parenchyma and control liver tissues.Vascular invasion was significantly related to GPC3 expression(P < 0.05).Recurrence-free survival was significantly longer for patients without GPC3 mRNA overexpression(> 3.5 × 10-2) and those without vascular invasion(P < 0.05 for both).CONCLUSION:GPC3 expression may serve as a valuable diagnostic marker for HCC.GPC3 mRNA overexpression may be an adverse indicator for HCC patients after liver transplantation.展开更多
文摘血浆IL-8是新生儿早期细菌感染(EOBI)的早期诊断指标,但是其半衰期较短。而净化剂溶解的全血(DLWB)IL-8既包括细胞外IL-8,也包括细胞结合型IL-8。此目的是研究健康新生儿和怀疑EOBI新生儿的血浆和DLWB中IL-8的代谢动力学,进而检证DLWB 中IL-8浓度测定对诊断EOBI具有更高的敏感性这一假想。研究组包括了61例具有EOBI临床或血清学征象的新生儿;188例具有感染风险因素但没有EOBI的新生儿编入对照组。测定血浆和DLWB中IL-8的浓度。在对照组中,新生儿直到出生后24 h内DLWB中IL-8浓度比相应的血浆IL-8浓度(34.2 ng/L,s= 18.1)升高了280倍(9 599 ng/L,s=4 433)。DLWB中IL-8浓度对EOBI的敏感度与血浆相比,出生6 h后是0.97 vs 0.71,出生24 h后是0.70 vs 0.32。两者的特异性相应值相比,出生6 h后是0.95 vs 0.90,出生24 h 后是0.92 vs 0.99。出生24 h后,DLWB中IL-8EOBI 阴性预测值与血浆IL-8相比是0.80 vs 0.66。结果显示DLWB中IL-8在临床怀疑EOBI最初6 h内比血浆中IL-8具有较高的敏感性。而且其增高能保持较长时间。笔者认为检测DLWB中IL-8的水平对EOBI的诊断具有较高的敏感性。
文摘Our objective was to compare the blood pressure of 20- y-old very low birth weight (VLBW; < 1.5 kg) individuals with that of normal birth weight (NBW) control individuals. The population included 195 VLBW (92 female and 103 male) and 208 NBW (107 female and 101 male) individuals who were born between 1977 and 1979. Independent effects of birth weight status (VLBW versus NBW) and within the VLBW cohort of intrauterine growth (birth weight z score) were examined via multiple regression analyses. VLBW individuals had a higher mean systolic blood pressure (SBP) than NBW control individuals (114 ± 11 versus 112± 13 mm Hg). SBP for VLBW female infants was 110± 9 versus NBW 107± 12 and for VLBW male individuals was 118± 11 versus NBW 117± 11 mm Hg. After adjustment for gender, race, and maternal education, the difference in SBP between VLBW and NBW individuals was 1.9 mm Hg but was 3.5 mm after also adjustment for later size (20- y weight and height z scores), which reflects catch-up growth. For female individuals, the difference in SBP between VLBW and NBW individuals was significant both unadjusted and adjusted for later size, whereas for male individuals, the differencewas significant only after adjustment for later size. Intrauterine growth did not have a significant effect on SBP within the VLBW group, even after adjustment for later size. VLBW individuals, specifically female individuals, have a higher SBP than NBW control individuals. This is not explained by intrauterine growth failure.
文摘On the basis of mutual compensation of mobility and threshold voltage temperature effects, a stable CMOS band-gap voltage reference circuit was designed and fabricated in CSMC-HJ 0.6 μm CMOS technology. Operating from 0 to 85 ℃ under a supply voltage ranging from 4.5 to 5.5 V, the voltage reference circuit offers an output reference voltage ranging from 1.122 to 1.176 V and a voltage variation less than ±3.70%. The chip size including bonding pads is only 0.4 mm×0.4 mm and the power dissipation falls inside the scope of 28.3 to 48.8 mW operating at a supply voltage of 4.5 to 5.5 V.
基金the National High Technology Research and Development Program of China(2007AA03Z524)
文摘The Reynolds stress transport model and the Eulerian two-fluid model provided by the FLUENT code were applied to evaluate the gas-particle two-phase flow in the ceramic filter vessel. The ceramic filter vessel contains six candle filters, which are arranged in the form of equilateral hexagon. The variation of the areal density of the filter cake during the filtration and the back-pulse process were analyzed. The coupling effect between filters, gas and solid, filtration and pulse cleaning process were investigated, respectively. The numerical results show a good approach to predict the particle distribution in the vessel and the particle deposition on the filter element. This study provides the base for the intensive study on the analysis of the gas-particle flow in the filter vessel.
基金supported by Fund of National Science & Technology monumental projects under Grants No.61105015,NO.61401239,NO.2012-364-641-209
文摘Foreground detection is a fundamental step in visual surveillance.However,accurate foreground detection is still a challenging task especially in dynamic backgrounds.In this paper,we present a nonparametric approach to foreground detection in dynamic backgrounds.It uses a history of recently pixel values to estimate background model.Besides,the adaptive threshold and spatial coherence are introduced to enhance robustness against false detections.Experimental results indicate that our approach achieves better performance in dynamic backgrounds compared with several approaches.
基金Supported by Tianjin Municipal Health Bureau Key Project for Key Laboratory for Critical Care Medicine Development
文摘AIM:To investigate the diagnostic value of glypican-3(GPC3) and its relationship with hepatocellular carcinoma(HCC) recurrence after liver transplantation.METHODS:HCC tissue samples(n = 31) obtained from patients who had undergone liver transplantation were analyzed.GPC3 mRNA and protein expression were analyzed by TaqMan real-time reverse transcription-polymerase chain reaction and immunohistochemistry.Correlation between the GPC3 expression and clinicopathological features was analyzed.The potential prognostic value of GPC3 was investigated by comparing recurrence-free survival between HCC patients with and without GPC3 expression.RESULTS:Using a cutoff value of 3.5 × 10-2,20 of 31 cancerous tissues had expression values of > 3.5 × 10-2,whereas 3 of 31 adjacent non-neoplastic parenchyma and 0 of 20 control liver tissues had expression values of > 3.5 × 10-2(P < 0.001).GPC3 protein was immunoexpressed in 68% of cancerous tissues,but not in adjacent non-neoplastic parenchyma and control liver tissues.Vascular invasion was significantly related to GPC3 expression(P < 0.05).Recurrence-free survival was significantly longer for patients without GPC3 mRNA overexpression(> 3.5 × 10-2) and those without vascular invasion(P < 0.05 for both).CONCLUSION:GPC3 expression may serve as a valuable diagnostic marker for HCC.GPC3 mRNA overexpression may be an adverse indicator for HCC patients after liver transplantation.
