读马克思论音乐

马克思对音乐的论述大致涉及五个方面：关于“音乐感的耳朵”；关于“歌唱家倍尔西阿尼的无比性”；关于“莫扎特的《安魂曲》大部分不是莫扎特自己作的”；关于“钢琴演奏者＊生产了音乐”；关于“勇敢的战斗的呼声”。马克思在论及这些问题时，表达了自己对音乐的审＊美关系、相比较性、分工协作、劳动的区分和特殊的社会功能等问题的精辟见解，无疑是文艺学＊美学研究时时象和范围。

Canonical Correlation Analysis of Agronomic Characters of Brassica juncea in Western China

[Objective] The study aimed at exploring the relationship among the agronomic characters of B. juncea in western China, in order to provide scientific basis for the breeding of B. juncea in western China. [Method] 39 B. juncea materials from western China were used for the canonical correlation analysis, and canonical correlations between each pair of the four ecological character （containing 18 variables） were verified, including yield characters （5 variables）, caulis characters （6 variables）, branch characters （3 variables） and pod characters （3 variables）. [Result] Yield per plant of B. juncea in western China suffered a tremendous influence from effective pod number per plant while was not significantly affected by the total pod number per plant, seed number per pod and 1 000-seed weight; the most important character related with the yield character of B. juncea in western China was caulis character, followed by the branch character and pod character; yield characters, caulis characters, branch characters and pod characters of B. juncea in western China were closely correlated. [Conclusion] In order to improve the yield characters of B. juncea in western China, caulis characters should be focused on, followed by branch characters and pod characters; rapeseed varieties with high performance in total pod number per plant and effective pod number per plant should be chosen through the perspectives of effective branch number, plant height, pod number of main inflorescence, fruit stalk number of main inflorescence and other traits, while rapeseed varieties with high performance in seed number per pod and 1 000-seed weight should be chosen through the perspectives of beak length and other traits.

Quantitative structure-activity relationship of 2-alkyl-4-(biphenylylmethoxy) pyridine derivatives with AT1 receptor antagonistic activity

The quantitative structure-activity relationship(QSAR) of 2-alkyl-4-(biphenylylmethoxy) pyridine derivatives was studied.Three different alignment methods were used to get the models of the comparative molecular field analysis(CoMFA),the comparative molecular similarity indices analysis(CoMSIA),and the hologram quantitative structure?activity relationship(HQSAR).The statistical results from the established models show believable predictivity based on the cross-validated value(q2>0.5) and the non-validated value(r2>0.9),The analysis on contour maps of CoMFA and CoMSIA models suggests that hydrophobic and hydrogen-bond acceptor fields are important factors that affect the AT1 antagonistic activity of 2-alkyl-4-(biphenylylmethoxy) pyridine derivatives besides the steric and electrostatic fields,The structural modification information from different atom contributions in the HQSAR model is in agreement with that in the 3D-QSAR models.

A Comparison between Heathcliff and Chillingworth from the Perspective of Romanticism

Heathcliff and Chillingworth are the two typical satan type heroes among literature works. To some extent, their revenge is similar, but there are also differences. However, there are few comparisons between the two heroes from the perspective of romanticism. From the analysis of the author＇s living background and their literary genre of the two works, the paper will analyse the reasons why Heathcliff and Chillingworth want to revenge, and reflect their similarities and differences in terms of their character, means, ending, and so on. The paper will analyse the two heroes by using the methods of literature data collection, text comparison and induction, and come to a conclusion that the romanticism carried by the two authors is influential in shaping the two satan type heroes. Thus to gain more details about the similarities of the two cruel revenger, and the differences of their individuality and different ways of revenge.

3D-QSAR and action mechanism of potential dual inhibitors towards AP-1 and NF-κB

Three-dimensional quantitative structure-activity relationship （3D-QSAR） and docking studies of a series of novel dioxopyrrolinyl-amino-pyrimidine derivatives, which are potential dual inhibitors mediating a transcriptional activation towards protein-1 （AP-1） and nuclear factor kappa B （NF-κB）, have been carried out. The QS, AR models established by comparative molecular field analysis （CoMFA） and comparative molecular similarity index analysis （CoMSIA） show a good predictive ability with cross-validated coefficients q2 of 0.644 and 0.636, respectively. The docking result shows that there are quite lower average values of the flexible and rigid energy scores on the selected binding sites, meanwhile, it further shows that the binding sites just fall on the joint regions between AP-1 （and NF-κB） and DNA. The reason that these analogues have inhibition function towards AP-I and NF-κB is that their existence on these joint regions can effectively prevent free AP-I and NF-κB from binding to DNA. These results can offer a valuable theoretical reference to the pharmaceutical molecular design as well as the action mechanism analysis.

Phase group synchronization between any signals and its physical characteristics

The phase group synchronization between any signals is further revealed,which is based on proposing the new concepts of the greatest common factor frequency,the least common multiple period,quantized phase shift resolution,equivalent phase comparison frequency and so on.Then the problem of phase comparison and processing between different frequency signals is solved and shown in detail.Using the basic principle and the variation law of group phase difference,the frequency stability better than 10-14/s can be easily obtained in the time&frequency measurement and control domain,and experimental results also show the phase relations between atomic energy level transition signal and the locked crystal oscillator signal in an active hydrogen atomic clock are strict phase group synchronization,and locked precision with 10-13/s can be reached based on phase group synchronization.The phase group synchronization can provide technical support to frequency linking among radio frequency,microwave and light frequency.

Biosynthesis, property comparison, and hemocompatibility of bacterial and haloarchaeal poly(3-hydroxybutyrate-co-3-hydroxyvalerate)

Polyhydroxyalkanoates （PHAs） are a class of natural biopolyesters accumulated intracellularly by many microorganisms. These polymers have attracted particular attention as green plastic in biomedical and industrial applications due to their good biodegradability and bio- compatibility. Poly（3-hydroxybutyrate-co-3-hydroxyvaler- ate） （PHBV） is one of the most common members of PHAs. However, there is no report comparing the properties of PHBV from different groups of producers, e.g., bacteria and haloarchaea. In this study, two types of PHBV copolymers were synthesized in Halogranum amylolyticum and Ralstonia eutropha, respectively, by feeding different carbon sources. They possessed a similar concentration of 3HV monomers （21 tool%） and were named PHBV-H （produced by H. arnylolyticum） and PHBV-B （produced by R. eutropha） based on their source. Interestingly, they exhibited different behaviors especially in thermal stabil- ity, melting temperature, crystallinity percentage, and mechanical properties. Furthermore, the films of PHBV-Hand PHBV-B possessed different surface properties, such as surface roughness, wettability, and surface free energy. The value of hemolysis on the PHBV-H film was lower in comparison with the PHBV-B film, although both values were within the limit of 5 % permissible for biomaterials. Notably, few inactivated platelets adhered to the surface of the PHBV-H film, whereas numerous activated platelets were seen on film PHBV-B. These results indicated that PHBV-H was a better potential component of blood-contact biomaterials than PHBV-B. Our study clearly revealed that the properties of PHAs are source dependent and haloarchaeal species provide a new opportunity for the production of desired PHAs.

3D-QSAR and docking studies on 2-arylbenzoxazole and linker-Y transthyretin amyloidogenesis inhibitors

Transthyretin(TTR),a plasma protein with a tetramer structure,could form amyloid fibril associated with several human diseases through the dissociation of tetramer and the misfolding of monomer.These amyloidogenesis can be inhibited by small molecules which bind to the central channel of TTR.A number of small molecules like 2-arylbenzoxazoles(ABZ)analogues are proposed as promising therapeutic strategy to treat amyloidosis.In this work,comparative molecular field analysis(CoMFA)and comparative molecular similarity indices analysis(CoMSIA)three-dimensional quantitative structure-activity relationship(3D-QSAR)and docking studies were performed on series of 2-arylbenzoxazoles(ABZ)and linker-Y analogues to investigate the inhibitory activities of TTR amyloidogenesis at atomic level.Significant correlation coefficients for ABZ series(CoMFA,r2=0.877,q2=0.431;CoMSIA,r2=0.836,q2=0.447)and those for linker-Y series(CoMFA,r2=0.828,q2=0.522;CoMSIA,r2=0.800,q2=0.493)were obtained,and the generated models were validated using test sets.In addition,docking studies on 6 compounds binding to TTR were performed to analyze the forward or reverse binding mode and interactions between molecules and TTR.These results from 3D-QSAR and docking studies have great significance for designing novel TTR amyloidogenesis inhibitors in the future.