A novel microscopic interferometry with ability of frequency-variation and phase-shifting is proposed for microstructures testing. By using acousto-optic technique, sequential carriers can be generated with different ...A novel microscopic interferometry with ability of frequency-variation and phase-shifting is proposed for microstructures testing. By using acousto-optic technique, sequential carriers can be generated with different spatial frequencies so that the temporal phase unwrapping method can be applied for decoding the height information. Combined with phase-shifting technique realized by spatial light modulator, this method is especially suitable for interferometric measurement with high precision and large dynamic range.展开更多
Objective To explore the interaction of Anxa2 with P-Glycoprotein （P-gp） in the migration and invasion of the multidrug-resistant （MDR） human breast cancer cell line MCF-7/ADR. Methods A pair of short hairpin RNA ...Objective To explore the interaction of Anxa2 with P-Glycoprotein （P-gp） in the migration and invasion of the multidrug-resistant （MDR） human breast cancer cell line MCF-7/ADR. Methods A pair of short hairpin RNA （shRNA） targeting P-gp was transfected into MCF-7/ADR cells, and monoclonal cell strains were screened. The expression of P-gp was detected by Western blot. Transwell chambers were used to observe the cell migration capacity and invasion ability. The interaction between P-gp and Anxa2 was examined by immunoprecipitation and immunofluorescence confocal microscopy analyses. Results P-gp expression was significantly knocked down, and there were notable decreasing trends in the migration and invasion capability of MDR breast cancer cells （P〈0.05）. There was a close interaction between Anxa2 and P-gp. Conclusions MCF-7/ADR is an MDR human breast cancer cell line with high migration and invasion abilities. The knockdown of P-gp notably impaired the migration and invasion abilities of the tumor cells. The interaction of Anxa2 with P-pg may play an important role in time enhanced invasiveness of MDR human breast cancer cells.展开更多
The objective of this research was to enhance adsorption capacity of Acacia nilotica （keekar） sawdust for the abatement of chromium bearing wastewater and to investigate the effect of process parameters on adsorptio...The objective of this research was to enhance adsorption capacity of Acacia nilotica （keekar） sawdust for the abatement of chromium bearing wastewater and to investigate the effect of process parameters on adsorption capacity. The sawdust was activated by acid wash and functionalized subsequently with formaldehyde. Functionalization of activated sawdust raised its chromium removal efficiency of almost 10% as compared to its adsorption removal efficiency of HCl treated sawdust in a batch adsorption study. Adsorption kinetic data provided better fitting with pseudo second order model. Maximum adsorption capacity calculated through the best fitting Langmuir model was 6.34 mg·g^-1 and 8.2 mg·g^-1 for HCl treated and formaldehyde functionalized sawdust adsorbents, respectively. The adsorption of Cr（VI） was endothermic when studied by varying temperature from 20℃ to 50℃ for both activated and functionalized adsorbents.展开更多
A predominant benefit of social living is the ability to share knowledge that cannot be gained through the information an individual accumulates based on its personal experience alone. Traditional computational models...A predominant benefit of social living is the ability to share knowledge that cannot be gained through the information an individual accumulates based on its personal experience alone. Traditional computational models have portrayed sharing knowledge through interactions among members of social groups via dyadic networks. Such models aim at understanding the percolation of information among individuals and groups to identify potential limitations to successful knowledge transfer. How- ever, because many real-world interactions are not solely pairwise, i.e., several group members may obtain information from one another simultaneously, it is necessary to understand more than dyadic communication and learning processes to capture their full complexity. We detail a modeling framework based on the simplicial set, a concept from algebraic topology, which allows elegant encapsulation of multi-agent interactions. Such a model system allows us to analyze how individual information within groups accumulates as the group＇s collective set of knowledge, which may be different than the simple union of individually contained information. Furthermore, the simplicial modeling approach we propose allows us to investigate how information accumulates via sub-group interactions, offering insight into complex aspects of multi-way communication systems. The fundamental change in modeling strategy we offer here allows us to move from portraying knowledge as a ＂token＂, passed from signaler to receiver, to portraying knowledge as a set of accumulating building blocks from which novel ideas can emerge. We provide an explanation of relevant mathematical concepts in a way that promotes accessibility to a general audience [Current Zoology 61 （1）： 114--127, 2015].展开更多
基金This work is supported by Natural Science Foundation of China(grants 60275012)Natural Science Foundation of Guangdongprovince (grant 06028584)the Research Project of Science& Technology from Shenzhen Government (Grant No.200619).
文摘A novel microscopic interferometry with ability of frequency-variation and phase-shifting is proposed for microstructures testing. By using acousto-optic technique, sequential carriers can be generated with different spatial frequencies so that the temporal phase unwrapping method can be applied for decoding the height information. Combined with phase-shifting technique realized by spatial light modulator, this method is especially suitable for interferometric measurement with high precision and large dynamic range.
基金supported by grants from the National Natural Science Foundation of China(No.81071731 and 81001188)the Changjiang Scholars and Innovative Research Team(No.IRT1076)the Tianjin Higher Education Science & Technology Fund Planning Project(No.20100120)
文摘Objective To explore the interaction of Anxa2 with P-Glycoprotein （P-gp） in the migration and invasion of the multidrug-resistant （MDR） human breast cancer cell line MCF-7/ADR. Methods A pair of short hairpin RNA （shRNA） targeting P-gp was transfected into MCF-7/ADR cells, and monoclonal cell strains were screened. The expression of P-gp was detected by Western blot. Transwell chambers were used to observe the cell migration capacity and invasion ability. The interaction between P-gp and Anxa2 was examined by immunoprecipitation and immunofluorescence confocal microscopy analyses. Results P-gp expression was significantly knocked down, and there were notable decreasing trends in the migration and invasion capability of MDR breast cancer cells （P〈0.05）. There was a close interaction between Anxa2 and P-gp. Conclusions MCF-7/ADR is an MDR human breast cancer cell line with high migration and invasion abilities. The knockdown of P-gp notably impaired the migration and invasion abilities of the tumor cells. The interaction of Anxa2 with P-pg may play an important role in time enhanced invasiveness of MDR human breast cancer cells.
文摘The objective of this research was to enhance adsorption capacity of Acacia nilotica （keekar） sawdust for the abatement of chromium bearing wastewater and to investigate the effect of process parameters on adsorption capacity. The sawdust was activated by acid wash and functionalized subsequently with formaldehyde. Functionalization of activated sawdust raised its chromium removal efficiency of almost 10% as compared to its adsorption removal efficiency of HCl treated sawdust in a batch adsorption study. Adsorption kinetic data provided better fitting with pseudo second order model. Maximum adsorption capacity calculated through the best fitting Langmuir model was 6.34 mg·g^-1 and 8.2 mg·g^-1 for HCl treated and formaldehyde functionalized sawdust adsorbents, respectively. The adsorption of Cr（VI） was endothermic when studied by varying temperature from 20℃ to 50℃ for both activated and functionalized adsorbents.
文摘A predominant benefit of social living is the ability to share knowledge that cannot be gained through the information an individual accumulates based on its personal experience alone. Traditional computational models have portrayed sharing knowledge through interactions among members of social groups via dyadic networks. Such models aim at understanding the percolation of information among individuals and groups to identify potential limitations to successful knowledge transfer. How- ever, because many real-world interactions are not solely pairwise, i.e., several group members may obtain information from one another simultaneously, it is necessary to understand more than dyadic communication and learning processes to capture their full complexity. We detail a modeling framework based on the simplicial set, a concept from algebraic topology, which allows elegant encapsulation of multi-agent interactions. Such a model system allows us to analyze how individual information within groups accumulates as the group＇s collective set of knowledge, which may be different than the simple union of individually contained information. Furthermore, the simplicial modeling approach we propose allows us to investigate how information accumulates via sub-group interactions, offering insight into complex aspects of multi-way communication systems. The fundamental change in modeling strategy we offer here allows us to move from portraying knowledge as a ＂token＂, passed from signaler to receiver, to portraying knowledge as a set of accumulating building blocks from which novel ideas can emerge. We provide an explanation of relevant mathematical concepts in a way that promotes accessibility to a general audience [Current Zoology 61 （1）： 114--127, 2015].
