Malignant melanoma, characterized by invasive local growth and early formation of metastases, is the most aggressive type of skin cancer. Melanoma inhibitory activity （MIA）, secreted by malignant melanoma cells, int...Malignant melanoma, characterized by invasive local growth and early formation of metastases, is the most aggressive type of skin cancer. Melanoma inhibitory activity （MIA）, secreted by malignant melanoma cells, interacts with the cell adhesion receptors, integrins a4131 and 05131, facilitating cell detachment and promoting formation of me- tastases. In the present study, we demonstrate that MIA secretion is confined to the rear end of migrating cells, while in non-migrating cells MIA accumulates in the actin cortex. MIA protein takes a conventional secretory pathway including coat protein complex I （COPI）- and coat protein complex II （COPII）-dependent protein transport to the cell periphery, where its final release depends on intracellular Ca2＋ ions. Interestingly, the Ca2＋-activated K＋-channel, subfamily N, member 4 （KCa3.1）, known to be active at the rear end of migrating cells, was found to support MIA secretion. Secretion was diminished by the specific KCa3.1 channel inhibitor TRAM-34 and by expression of dominant- negative mutants of the channel. In summary, we have elucidated the migration-associated transport of MIA protein to the cell rear and also disclosed a new mechanism by which KCa3.1 potassium channels promote cell migration.展开更多
We present a scheme to realize geometric phase-shift gate for two superconducting quantum interference device （SQUID） qubits coupled to a single-mode microwave field. The geometric phase-shift gate operation is perf...We present a scheme to realize geometric phase-shift gate for two superconducting quantum interference device （SQUID） qubits coupled to a single-mode microwave field. The geometric phase-shift gate operation is performed in two lower flux states, and the excited state [2〉 would not participate in the procedure. The SQUIDs undergo no transitions during the gate operation. Thus, the docoherence due to energy spontaneous emission based on the levels of SQUIDs are suppressed. The gate is insensitive to the cavity decay throughout the operation since the cavity mode is displaced along a circle in the phase space, acquiring a phase conditional upon the two lower flux states of the SQUID qubits, and the cavity mode is still in the original vacuum state. Based on the SQUID qubits interacting with the cavity mode, our proposed approach may open promising prospects for quantum iogic in SQUID-system.展开更多
We give the brief review on the related definition of the geometric phase independent of specific physical system based on the displacement opreator and the sqeezed operator, then show how the displacement operator an...We give the brief review on the related definition of the geometric phase independent of specific physical system based on the displacement opreator and the sqeezed operator, then show how the displacement operator and the squeezed operator can induce the general geometric phase. By means of the displacement operator and the squeezed operator concerning the circuit cavity mode state along a closed path in the phase space, we discuss specifically how to implement a two-qubit geometric phase gate in circuit quantum electrodynamics with both single photon interaction and two-photon interaction between the superconducting qubits and the circuit cavity modes. The experimental feasibility is discussed in detail.展开更多
文摘Malignant melanoma, characterized by invasive local growth and early formation of metastases, is the most aggressive type of skin cancer. Melanoma inhibitory activity （MIA）, secreted by malignant melanoma cells, interacts with the cell adhesion receptors, integrins a4131 and 05131, facilitating cell detachment and promoting formation of me- tastases. In the present study, we demonstrate that MIA secretion is confined to the rear end of migrating cells, while in non-migrating cells MIA accumulates in the actin cortex. MIA protein takes a conventional secretory pathway including coat protein complex I （COPI）- and coat protein complex II （COPII）-dependent protein transport to the cell periphery, where its final release depends on intracellular Ca2＋ ions. Interestingly, the Ca2＋-activated K＋-channel, subfamily N, member 4 （KCa3.1）, known to be active at the rear end of migrating cells, was found to support MIA secretion. Secretion was diminished by the specific KCa3.1 channel inhibitor TRAM-34 and by expression of dominant- negative mutants of the channel. In summary, we have elucidated the migration-associated transport of MIA protein to the cell rear and also disclosed a new mechanism by which KCa3.1 potassium channels promote cell migration.
基金The project supported by the National Natural Science Foundation of China under Grant No. 10574126.
文摘We present a scheme to realize geometric phase-shift gate for two superconducting quantum interference device （SQUID） qubits coupled to a single-mode microwave field. The geometric phase-shift gate operation is performed in two lower flux states, and the excited state [2〉 would not participate in the procedure. The SQUIDs undergo no transitions during the gate operation. Thus, the docoherence due to energy spontaneous emission based on the levels of SQUIDs are suppressed. The gate is insensitive to the cavity decay throughout the operation since the cavity mode is displaced along a circle in the phase space, acquiring a phase conditional upon the two lower flux states of the SQUID qubits, and the cavity mode is still in the original vacuum state. Based on the SQUID qubits interacting with the cavity mode, our proposed approach may open promising prospects for quantum iogic in SQUID-system.
基金Supported by the National Science Foundation of China under Grant Nos. 11074070, 10774042, and 10774163the Nature Science Foundation of Hunan Province under Grant No. 09JJ3121+1 种基金the Key Project of Science and Technology of Hunan Province under Grant Nos. 2010FJ2005 and 2008FJ4217the NKBRSFC under Grant No. 2010CB922904
文摘We give the brief review on the related definition of the geometric phase independent of specific physical system based on the displacement opreator and the sqeezed operator, then show how the displacement operator and the squeezed operator can induce the general geometric phase. By means of the displacement operator and the squeezed operator concerning the circuit cavity mode state along a closed path in the phase space, we discuss specifically how to implement a two-qubit geometric phase gate in circuit quantum electrodynamics with both single photon interaction and two-photon interaction between the superconducting qubits and the circuit cavity modes. The experimental feasibility is discussed in detail.
