企业文化与校园文化的“真”与“仿”在一体化教室建设中的融合

引入企业文化,营造有特色的职业学校校园文化氛围已成为中职学校教育教学改革的潮流。企业文化与校园文化"真"、"仿"的关系,决定了校园文化不能照搬企业文化,而应做到"神似"。我们在工学一体化专业教室建设中对两种文化的融合方法进行了有益探索,希望能在中职学校一体化教室文化建设方面起到参考作用。

Dynamic Simulation Study of Friction and Lubrication on ICE Bearings

Friction and lubrication simulation analysis of internal combustion engine bearings are studied. A series of software implementary precepts for mathematical modeling, to analytic calculating and realizing simulation outcome are brought forward. As a dynamic simulating technique is introduced into the process of engine bearing design, simulation models of the oil film are built and the emulational analysis of the shaft center track is carried out. A software program package “Engine Bearing Friction and Lubrication Dynamic Simulation System” is developed to realize the real time simulation of the working status of bearing during the design process. Through developing virtualized products, the defects of the product design can be found in time and improve the products at once. Thus the purpose of predicting and controlling the cost, quality and design period of the products can be achieved.

Cross Spectral Estimation and Its Application in Missile Systems

A new method based on cross-spectrum estimation for the verification and validation of computer simulation models is expounded in accordance with the characteristics of missile systems. The new method can expose the differences between two time processes in several aspects and can also give quantitative analysis results about the statistical consistence between them. An application to an actual anti-tank missile system simulation is presented and the calculated results confirm the effectiveness of the method. The approach can also be employed to verify the simulation models of other dynamic systems.

Dynamic modeling of a parafoil system considering flap deflection

In order to better study the dynamic characteristics and the control strategy of parafoil systems,considering the effect of flap deflection as the control mechanism and regarding the parafoil and the payload as a rigid body,a six degrees-of-freedom(DOF)dynamic model of a parafoil system including three DOF for translational motion and three DOF for rotational motion,is established according to the K rchhoff motion equation.Since the flexible winged paafoil system flying at low altitude is more susceptibleto winds,the motion characteristics of the parafoil system Wth and Wthout winds are simulated and analyzed.Furthermore,the ardropm test is used to further verify the model.The comparison results show that the simulation trajectory roughly overlaps with the actual flight track.The horzontnl velocity of the simulation model is in good accordance with the airdrop test,with a deviation less than0.5m/s,while its simulated vertical velocity fuctuates slightly under the infuence of the wind,and shows a similar trend to the ardrop test.It is concludedthat the established model can well describe the characteristics of the parafoil system.

An improved crossbar array of memristor

This paper conducts an analysis of HP model of a memristor and memory cells of a differential type memristor,formsa classic array of the memristor using the HP model,and does the stimulation of its storage capacity.Based on differential typememristor cells,this paper proposes an improved crossbar array of the memristor,which can be applied in image storage.Bymeans of theoretical analysis and stimulation,this improved crossbar array of memristor has been proved to have bettergrayscale image storage capacity,and its peak signal-to-noise ratio(PSNR)has been improved by about30%.

Cabozantinib enhances the response of NSCLC cells with wild-type EGFR to erlotinib and pharmacodynamic modeling of their sequential combinations

The epidermal growth factor receptor（EGFR）—tyrosine kinase inhibitors（TKIs） monotherapies have limited efficacy in the treatment of EGFR mutation-negative non-small cell lung cancers（NSCLCs）. In the present study, we aimed to investigate the combined effect of erlotinib（ER） and cabozantinib（CAB） on NSCLC cell lines harboring wild-type EGFR and to optimize the dosage regimens using pharmacodynamic（PD） modeling and simulation. Therefore, we examined the combined effect of ER and CAB on cell viability, cloning, apoptosis induction, migration and growth dynamics in H1299 and A549 cells. PD modeling and simulation were also performed to quantitatively describe the H1299 cells growth dynamics and to optimize the dosage regimens as well. Our results showed that CAB effectively enhanced the sensitivity of both cell lines to ER. The PD models fitted the data well, and some important parameters were obtained. The exponential（λ_0） and linear（λ_1） growth rates of H1299 cells were 0.0241 h^（–1） and 360 cells？h^（–1）, respectively. The Emax of ER and CAB was 0.0091 h^（–1） and 0.0085 h^（–1）, and the EC50 was 0.812 μM and 1.16 μM, respectively. The synergistic effect observed in the experiments was further confirmed by the estimated combination index φ（1.37）,（95% confidence interval： 1.24–1.50）, obtained from PD modeling. Furthermore, the dosage regimens were optimized using simulations. In summary, both the experimental and modeling results demonstrated the synergistic interaction between ER and CAB in NSCLCs without EGFR mutations. Sequential combinations of ER and CAB provided an option for the therapy of the NSCLCs with wild-type EGFR, which would provide some references for preclinical study and translational research as well.