Sweet综合征一例

Sweet综合征又称急性发热性嗜中性皮肤病(Acute febrile neutrophilic dermatosis—AFND),笔者收治一例报告如下。

圆形切除面部良性小丘疹圆顶形黑色素细胞痣

Background. Patients frequently request the removal of benign, papular and dome-shaped nevi for cosmetic or functional reasons. Total excision is probably the most widely used method of removal. Aim. To introduce the round excision technique for the treatment of benign, papular and dome-shaped nevi on the face. Methods. In a prospective study, 36 benign, papular or dome-shaped nevi of all types were removed by the round excision technique. The lesions were circumscribed with a number 15 scalpel blade, 2 mm beyond the limits, with incision to the full depth of the dermis, and removed by cutting horizontally at the maximum depth of the circular incision. Histologic examinations were performed for all specimens. Results. Complete removal of nevi was achieved in all patients with excellent or good cosmetic results. Of the 36 nevi, 24 were intradermal and 12 were compound nevi. Dog-ear formation was observed in only one patient. Conclusion. Round excision may be a better alternative to conventional fusiformor shaveexcision of benign, dome-shaped or papular nevi of the face.

甲氨蝶呤治疗持久性隆起性红斑1例

患者女,37岁,因四肢斑块伴胀痛半年,加重2周于2020年1月来我所就诊。半年前患者无明显诱因四肢出现红斑,渐增多变大,伴疼痛。于外院行病理检查,示右小腿皮损真皮乳头水肿不明显,真皮全层及皮下脂肪血管丛周围见大量中性粒细胞、淋巴细胞浸润,可见核尘,血管纤维样改变不明显。免疫荧光示基底膜处C3、IgA、IgG、IgM均阴性。诊断为Sweet综合征,予口服甲泼尼龙和沙利度胺等治疗3个月,治疗期间红斑部分消退但病情反复伴破溃糜烂。2周前双手背及面部出现类似皮疹,遂至我所进一步诊治。患者无发热寒战、咳嗽咳痰、头晕头痛,既往体健,家族中无类似疾病患者。