抗真菌颗粒剂内服配合香莲外洗液外用治疗足癣疗效观察

目的:探讨抗真菌颗粒剂内服配合香莲外洗液外用治疗足癣的疗效和安全性。方法:采用随机平行对照单盲法设计,入选病例随机分为治疗组和对照组,治疗组予以抗真菌颗粒剂内服及香莲外洗液外用,对照组单用香莲外洗液外用;2周为1个疗程;分别治疗2个疗程,对停药时及停药2周后的疗效进行分析评价。结果:疗效评价的结论建立在ITT意图治疗分析的基础上;治疗组和对照组相比,其在停药两周时其临床疗效、真菌学清除率、综合疗效以及皮损消退时间均优于对照组(P<0.05);治疗组有1例发生局部皮肤红肿,发生率为3.57%。结论:抗真菌颗粒剂内服配合香莲外洗液外用具有良好的疗效和安全性,值得临床推广运用。

好氧颗粒污泥失稳过程实验及成因分析

以序批式反应器培养的好氧颗粒污泥为对象,从出水MLSS、COD、污泥粒径分布、污泥圆形度及复杂度角度,研究颗粒污泥失稳过程及其成因。结果表明,出水MLSS从接种时的693.3 mg/L降低至稳定运行至67 d时的9.5 mg/L,出水COD保持在50 mg/L以下,去除率由89.3%增加至98.1%。随着颗粒污泥的失稳,出水MLSS由9.5 mg/L增加至507.6 mg/L,出水COD增加至在70 mg/L,去除率为94.2%,好氧颗粒污泥逐渐转变为真菌颗粒。颗粒粒径急剧增大,圆形度降低,复杂度增加,说明失稳后的真菌形状不规则,沉降性能因此变差。这是由于在有机冲击负荷条件下,部分有机物未能充分降解而酸化,导致pH值提高,丝状真菌在与细菌的竞争中有优势,导致菌群失稳,功能菌群被淘汰,最终导致颗粒失稳。

Transformation and performance of granular sequence batch reactor under conventional organic loading rate condition

Laboratory experiments were conducted to investigate the transformation and performance of a granular sequence batch reactor(SBR) under the conventional organic loading rate(OLR) condition.Aerobic granules were successfully cultivated in a SBR by means of alternative feeding load combined with reducing settling time after 60 d operational period.Subsequently,the black fungal granules were presented in reactor because of the filamentous overgrowth on the surface of aerobic granules.A small amount of fungal granules had no effect on the performance of granular SBR.Aerobic granules completely vanished and fungal granules eventually became the dominant species in subsequent 90 d operation after granulation.The three-dimensional excitation emission matrix(EEM) spectra result shows that the extracellular polymeric substances(EPS) component in both granules has no much difference,whereas the content of EPS in fungal granules is higher than that in bacterial granules.Due to their low bioactivity,the chemical oxidation demand(COD) and NH4-N removal efficiencies gradually decrease from 90.4%–96.5% and 99.5% to 71.8% and 32.9% respectively while the fungal granules become dominant in the SBR.