[Objective] This study aimed to investigate the biological characteristics of parasitic Fusarium fungi from tibetan Cordyceps sinensis. [Method] A Fusarium strain was isolated from fresh tibetan Cordyceps sinensis as ...[Objective] This study aimed to investigate the biological characteristics of parasitic Fusarium fungi from tibetan Cordyceps sinensis. [Method] A Fusarium strain was isolated from fresh tibetan Cordyceps sinensis as the experimental material, to observe the morphologies of Fusarium mycelium and spores. [Result] The isolated Fusarium fungus strain grew lushly on rice medium, with white and villiform myceliurn, and the villous stroma appeared in colors from beige to pink. After cultivated at （18 ± 4） ℃ for 14 d, the Fusarium strain produced milky white protrusions containing pale yellow chlamydospores, which can be divided into microconidiums and macroconidiums based on the different sizes. According to Ainsworth＇s classification system, the isolated strain belongs to Fusarium, Tuberculariales, Hyphomycetes, adelomycete subphylum. Further observation identified three types of macroconidium, and two of them showed distinct morphology, which was not described in Ainsworth＇s classification system. [Conclusion] The structure of the strain isolated from tibetan Cordyceps sinensis is significantly different from that of Fusariurn fungi recorded in relevant literatures, which requires further investigation.展开更多
Cancer cell dormancy is the main cause of cancer recurrence and failure of therapy as dormant cells evade not only the anticancer drugs but also the host immune system. These dormant cells veil themselves from detecti...Cancer cell dormancy is the main cause of cancer recurrence and failure of therapy as dormant cells evade not only the anticancer drugs but also the host immune system. These dormant cells veil themselves from detection by imaging and/or using biomarkers, which imposes an additional problem in targeting such cells. A similar form of hibernation process known as encystation is studied in detail for pathogenic unicellular eukaryotic microorganisms. By examination using microarray gene expression profiles, immunocytochemistry tools, and siRNAs during the process of encystation, understanding the covert features of cancer cell dormancy as proposed could be possible. This knowledge can be extended to dormant cancer cells to uncover the mechanisms that underlie this ghost, yet dangerous state of human cancers. We propose a strategy to induce dormancy and exit this state by application of knowledge gained from the encystation induction and retrieval processes in pathogenic eukaryotic microorganisms. Given that early detection and characterization of dormant malignant tumor cells is important as a general strategy to monitor and prevent the development of overt metastatic disease, this homology may enable the design of therapies that could either awake the dormant cell from dormancy to make it available for therapies or prolong such a phase to make cancer appear as a chronic disease展开更多
Tsangyang Gyatso＇s poems were widely circulated and still enjoy popularity. He was an influential living Buddha （Renpoche） in Tibetan Buddhism and a talented and legendary historical figure. Nowadays, more and more...Tsangyang Gyatso＇s poems were widely circulated and still enjoy popularity. He was an influential living Buddha （Renpoche） in Tibetan Buddhism and a talented and legendary historical figure. Nowadays, more and more scholars, poets and translators have devoted to the study of his works. Here we will focus on discussing the English translation of his poems and their value. We analyze texts of the Tsangyang Gyatso＇s Poems （Chinese-English） and seek to further study the translation principles such as ＂retaining truth, seeking goodness and preserving beauty＂. By doing this, we strive to improve the quality of translation, give consideration to the construction of the four elements such as poetic meaning, emotion, tone and intention, to enable the reader to achieve the senses and the acquisition of images, to provide more perfect translation in the ＂Tsangyang Gyatso Vogue＂, to promote the dissemination and sharing of Tibetan culture and to inject new vitality.展开更多
基金Supported by National Innovation Experiment Program for University Students from Tibet University(081069405)~~
文摘[Objective] This study aimed to investigate the biological characteristics of parasitic Fusarium fungi from tibetan Cordyceps sinensis. [Method] A Fusarium strain was isolated from fresh tibetan Cordyceps sinensis as the experimental material, to observe the morphologies of Fusarium mycelium and spores. [Result] The isolated Fusarium fungus strain grew lushly on rice medium, with white and villiform myceliurn, and the villous stroma appeared in colors from beige to pink. After cultivated at （18 ± 4） ℃ for 14 d, the Fusarium strain produced milky white protrusions containing pale yellow chlamydospores, which can be divided into microconidiums and macroconidiums based on the different sizes. According to Ainsworth＇s classification system, the isolated strain belongs to Fusarium, Tuberculariales, Hyphomycetes, adelomycete subphylum. Further observation identified three types of macroconidium, and two of them showed distinct morphology, which was not described in Ainsworth＇s classification system. [Conclusion] The structure of the strain isolated from tibetan Cordyceps sinensis is significantly different from that of Fusariurn fungi recorded in relevant literatures, which requires further investigation.
文摘Cancer cell dormancy is the main cause of cancer recurrence and failure of therapy as dormant cells evade not only the anticancer drugs but also the host immune system. These dormant cells veil themselves from detection by imaging and/or using biomarkers, which imposes an additional problem in targeting such cells. A similar form of hibernation process known as encystation is studied in detail for pathogenic unicellular eukaryotic microorganisms. By examination using microarray gene expression profiles, immunocytochemistry tools, and siRNAs during the process of encystation, understanding the covert features of cancer cell dormancy as proposed could be possible. This knowledge can be extended to dormant cancer cells to uncover the mechanisms that underlie this ghost, yet dangerous state of human cancers. We propose a strategy to induce dormancy and exit this state by application of knowledge gained from the encystation induction and retrieval processes in pathogenic eukaryotic microorganisms. Given that early detection and characterization of dormant malignant tumor cells is important as a general strategy to monitor and prevent the development of overt metastatic disease, this homology may enable the design of therapies that could either awake the dormant cell from dormancy to make it available for therapies or prolong such a phase to make cancer appear as a chronic disease
文摘Tsangyang Gyatso＇s poems were widely circulated and still enjoy popularity. He was an influential living Buddha （Renpoche） in Tibetan Buddhism and a talented and legendary historical figure. Nowadays, more and more scholars, poets and translators have devoted to the study of his works. Here we will focus on discussing the English translation of his poems and their value. We analyze texts of the Tsangyang Gyatso＇s Poems （Chinese-English） and seek to further study the translation principles such as ＂retaining truth, seeking goodness and preserving beauty＂. By doing this, we strive to improve the quality of translation, give consideration to the construction of the four elements such as poetic meaning, emotion, tone and intention, to enable the reader to achieve the senses and the acquisition of images, to provide more perfect translation in the ＂Tsangyang Gyatso Vogue＂, to promote the dissemination and sharing of Tibetan culture and to inject new vitality.
