A new species belonging to the genus Lesteva Latreille is described under the name of Lesteva ochra, sp. nov. It is collected from Zhejiang Province, China. The major characters are illustrated.
In this study, the role of melanopsin-expressing retinal ganglion cells （mRGCs） in the glaucoma-induced depressive behavioral response pattern was investigated. The CFP-D2 transgenic glaucoma animal model from five ...In this study, the role of melanopsin-expressing retinal ganglion cells （mRGCs） in the glaucoma-induced depressive behavioral response pattern was investigated. The CFP-D2 transgenic glaucoma animal model from five age groups was used in this study. Immunohistochemical labeling, quantitative analysis of mRGC morphology, open field test （OFT）, and statistical analysis were used. In comparison with C57 BL/6 mice, the age-matched CFP-D2 mice had significantly elevated intraocular pressure （lOP）. We observed parallel morphological changes in the retina, including a reduction in the density of cyan fluorescent protein- （CFP） expressing cells （cells mm^-2 at 2 months of age, 1309±26; 14 months, 878±30, P〈0.001）, mRGCs （2 months, 48_＋3; 14 months, 19±4, P〈0.001）, Brn3b-expressing RGCs （2 months, 1283±80; 14 months, 950±31, P〈0.001）, Brn-3b expressing mRGCs （5 months, 50.17%±5.5%; 14 months, 12.61%±3.8%, P〈0.001）, and reduction in the dendritic field size of mRGCs （mm^2 at 2 months, 0.077±0.015; 14 months, 0.065±0.015, P〈0.05）. CFP-D2 mice had hyperactive locomotor activity patterns based on OFT findings of the total distance traveled, number of entries into the center, and time spent in the center of the testing apparatus. The glaucoma induced hyperactive response pattern could be associated with dysfunctional mRGCs, most likely Brn-3b-positive mRGCs in CFP-D2 mice.展开更多
A custom built 1310 nm center wavelength swept source optical coherence tomography instrument was used to measure morphological changes in treated and newly diagnosed untreated glaucomatous human Schlemm’s canal(SC)....A custom built 1310 nm center wavelength swept source optical coherence tomography instrument was used to measure morphological changes in treated and newly diagnosed untreated glaucomatous human Schlemm’s canal(SC).Thirty-seven primary open-angle glaucoma patients were divided into two groups depending on the patients having been treated or not.The statistical results showed that there were significant differences between the treated and untreated groups’SC areas(treated,7935.6875±680.003μm2;untreated,3890.71875±871.49844μm2;P<0.001),the circumferences(treated,580.37891±44.96529μm;untreated,381.9026±41.22123μm;P<0.001),and the long diameters(treated,272.87806±25.7254μm;untreated,185.24047±19.72786μm;P<0.001).We hypothesize that,after drug treatment,the SC will expand and the morphometric values especially the areas will become larger,thus helping to reduce intraocular pressure.展开更多
基金This research was supported by the National Natural Science Foundation of China (30270188)
文摘A new species belonging to the genus Lesteva Latreille is described under the name of Lesteva ochra, sp. nov. It is collected from Zhejiang Province, China. The major characters are illustrated.
基金supported by the National Basic Research Program of China (2009CB320900 to Pu MingLiang,2011CB510206 to Pu MingLiangand Gao Jie)National Natural Science Foundation of China(30831160516 to Pu MingLiang)+2 种基金NIH EY04067 (N.C. Brecha)VAMerit Review (N.C. Brecha).supported by a summer fellowship from the PKU-UCLA Joint Research Institute
文摘In this study, the role of melanopsin-expressing retinal ganglion cells （mRGCs） in the glaucoma-induced depressive behavioral response pattern was investigated. The CFP-D2 transgenic glaucoma animal model from five age groups was used in this study. Immunohistochemical labeling, quantitative analysis of mRGC morphology, open field test （OFT）, and statistical analysis were used. In comparison with C57 BL/6 mice, the age-matched CFP-D2 mice had significantly elevated intraocular pressure （lOP）. We observed parallel morphological changes in the retina, including a reduction in the density of cyan fluorescent protein- （CFP） expressing cells （cells mm^-2 at 2 months of age, 1309±26; 14 months, 878±30, P〈0.001）, mRGCs （2 months, 48_＋3; 14 months, 19±4, P〈0.001）, Brn3b-expressing RGCs （2 months, 1283±80; 14 months, 950±31, P〈0.001）, Brn-3b expressing mRGCs （5 months, 50.17%±5.5%; 14 months, 12.61%±3.8%, P〈0.001）, and reduction in the dendritic field size of mRGCs （mm^2 at 2 months, 0.077±0.015; 14 months, 0.065±0.015, P〈0.05）. CFP-D2 mice had hyperactive locomotor activity patterns based on OFT findings of the total distance traveled, number of entries into the center, and time spent in the center of the testing apparatus. The glaucoma induced hyperactive response pattern could be associated with dysfunctional mRGCs, most likely Brn-3b-positive mRGCs in CFP-D2 mice.
基金supported by the Sichuan Youth Science&Technology Foundation(2013JQ0028)the National Natural Science Foundation of China(61108082)+1 种基金the West Light Foundation of the Chinese Academy of Sciencesthe National Major Scientific Equipment Program(2012YQ120080)
文摘A custom built 1310 nm center wavelength swept source optical coherence tomography instrument was used to measure morphological changes in treated and newly diagnosed untreated glaucomatous human Schlemm’s canal(SC).Thirty-seven primary open-angle glaucoma patients were divided into two groups depending on the patients having been treated or not.The statistical results showed that there were significant differences between the treated and untreated groups’SC areas(treated,7935.6875±680.003μm2;untreated,3890.71875±871.49844μm2;P<0.001),the circumferences(treated,580.37891±44.96529μm;untreated,381.9026±41.22123μm;P<0.001),and the long diameters(treated,272.87806±25.7254μm;untreated,185.24047±19.72786μm;P<0.001).We hypothesize that,after drug treatment,the SC will expand and the morphometric values especially the areas will become larger,thus helping to reduce intraocular pressure.
