To compare vitreous concentrations of triamcinolone acetonide (TA) achieved by prior therapeutic intravitreal and subtenon injections. Interventional case ser ies. Vitreous samples were collected from patients who req...To compare vitreous concentrations of triamcinolone acetonide (TA) achieved by prior therapeutic intravitreal and subtenon injections. Interventional case ser ies. Vitreous samples were collected from patients who required vitreous surgery , six having received a subtenon injection of TA and another six, an intravitrea l injection. Vitreous concentrations of TA were measured by high-performance li quid chromatography. Vitreous concentrations of TA after intravitreal injection were 1.22 ±.0.24 μg/ml, significantly higher than those after subtenon injecti on ( < 0.001 μg/ml, P=0.003). Vitreous concentrations of TA after subtenon inje ction and TA-assisted vitrectomy performed in a few patients to visualize the t ransparent vitreous gel were 0.20 ±0.11 μg/ml, an intermediate amount between these two groups. Much higher vitreous concentrations of TA after intravitreal i njection than subtenon injection may accelerate therapeutic effect when intravit real injections are given to reduce macular edema. Subtenon injections of TA may act via the sclera as opposed to the vitreous.展开更多
BACKGROUND AND OBJECTIVE: To evaluate the management of a series of eyes with magnetic intravitreal foreign bodies. PATIENTS AND METHODS: This retrospective r eview examined consecutive cases of ocular injury associat...BACKGROUND AND OBJECTIVE: To evaluate the management of a series of eyes with magnetic intravitreal foreign bodies. PATIENTS AND METHODS: This retrospective r eview examined consecutive cases of ocular injury associated with intraocular fo reign bodies; 71 eyes included had a single metallic intraocular foreign body (< 5 mm) located in the vitreous cavity removed by external magnet or intraocular forceps. Variables included preoperative and postoperative visual acuity, retina l break formation, retinal detachment, presence of an afferent pupillary defect, intraocular pressure, entrance site, foreign body size, method of extraction, a nd time between occurrence and surgical extraction. RESULTS: Factors predictive of good visual outcome (visual acuity >20/200) were: shortest interval between t rauma and foreign body extraction, preoperative visual acuity of 20/200 or bette r, and absence of afferent pupillary defect. CONCLUSIONS: In this nonrandomized study, good visual results could be obtained in eyes undergoing prompt foreign b ody removal, especially those with good preoperative visual acuity and no affere nt pupillary defect.展开更多
文摘To compare vitreous concentrations of triamcinolone acetonide (TA) achieved by prior therapeutic intravitreal and subtenon injections. Interventional case ser ies. Vitreous samples were collected from patients who required vitreous surgery , six having received a subtenon injection of TA and another six, an intravitrea l injection. Vitreous concentrations of TA were measured by high-performance li quid chromatography. Vitreous concentrations of TA after intravitreal injection were 1.22 ±.0.24 μg/ml, significantly higher than those after subtenon injecti on ( < 0.001 μg/ml, P=0.003). Vitreous concentrations of TA after subtenon inje ction and TA-assisted vitrectomy performed in a few patients to visualize the t ransparent vitreous gel were 0.20 ±0.11 μg/ml, an intermediate amount between these two groups. Much higher vitreous concentrations of TA after intravitreal i njection than subtenon injection may accelerate therapeutic effect when intravit real injections are given to reduce macular edema. Subtenon injections of TA may act via the sclera as opposed to the vitreous.
文摘BACKGROUND AND OBJECTIVE: To evaluate the management of a series of eyes with magnetic intravitreal foreign bodies. PATIENTS AND METHODS: This retrospective r eview examined consecutive cases of ocular injury associated with intraocular fo reign bodies; 71 eyes included had a single metallic intraocular foreign body (< 5 mm) located in the vitreous cavity removed by external magnet or intraocular forceps. Variables included preoperative and postoperative visual acuity, retina l break formation, retinal detachment, presence of an afferent pupillary defect, intraocular pressure, entrance site, foreign body size, method of extraction, a nd time between occurrence and surgical extraction. RESULTS: Factors predictive of good visual outcome (visual acuity >20/200) were: shortest interval between t rauma and foreign body extraction, preoperative visual acuity of 20/200 or bette r, and absence of afferent pupillary defect. CONCLUSIONS: In this nonrandomized study, good visual results could be obtained in eyes undergoing prompt foreign b ody removal, especially those with good preoperative visual acuity and no affere nt pupillary defect.
