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CONJUNCTIVAL IMPRESSION CYTOLOGY AFTER GLAUCOMA FILTERING SURGERY
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作者 A.Clement Corral M.A.Muriel Herrero +4 位作者 A.H.Estrada M.A.Corral G.Rebolleda F.J.Munoz-Negrete L.Rivas Jara 《国际眼科杂志》 CAS 2003年第1期30-30,共1页
Purpose: To evaluate the postoperative ocular surface modifications by conjunctival impression cytology after filtering surgery. Methods: We have prospectively studied 27 eyes of 23 patients who underwent trabeculecto... Purpose: To evaluate the postoperative ocular surface modifications by conjunctival impression cytology after filtering surgery. Methods: We have prospectively studied 27 eyes of 23 patients who underwent trabeculectomy or non-penetrating deep sclerec-tomy. Conjunctival impression cytology was performed before surgery and 15 days, 1,3 and 6 months after filtering surgery. We evaluated the degree of squamous metaplasia and the 展开更多
关键词 滤过术 结膜印记细胞学 术后 眼青变化
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Melanopsin-expressing retinal ganglion cell loss and behavioral analysis in the Thy1-CFP-DBA/2J mouse model of glaucoma 被引量:4
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作者 ZHANG Qi VUONG Helen +4 位作者 HUANG Xin WANG YanLing BRECHA Nicholas C. PU MingLiang GAO Jie 《Science China(Life Sciences)》 SCIE CAS 2013年第8期720-730,共11页
In this study, the role of melanopsin-expressing retinal ganglion cells (mRGCs) in the glaucoma-induced depressive behavioral response pattern was investigated. The CFP-D2 transgenic glaucoma animal model from five ... In this study, the role of melanopsin-expressing retinal ganglion cells (mRGCs) in the glaucoma-induced depressive behavioral response pattern was investigated. The CFP-D2 transgenic glaucoma animal model from five age groups was used in this study. Immunohistochemical labeling, quantitative analysis of mRGC morphology, open field test (OFT), and statistical analysis were used. In comparison with C57 BL/6 mice, the age-matched CFP-D2 mice had significantly elevated intraocular pressure (lOP). We observed parallel morphological changes in the retina, including a reduction in the density of cyan fluorescent protein- (CFP) expressing cells (cells mm^-2 at 2 months of age, 1309±26; 14 months, 878±30, P〈0.001), mRGCs (2 months, 48_+3; 14 months, 19±4, P〈0.001), Brn3b-expressing RGCs (2 months, 1283±80; 14 months, 950±31, P〈0.001), Brn-3b expressing mRGCs (5 months, 50.17%±5.5%; 14 months, 12.61%±3.8%, P〈0.001), and reduction in the dendritic field size of mRGCs (mm^2 at 2 months, 0.077±0.015; 14 months, 0.065±0.015, P〈0.05). CFP-D2 mice had hyperactive locomotor activity patterns based on OFT findings of the total distance traveled, number of entries into the center, and time spent in the center of the testing apparatus. The glaucoma induced hyperactive response pattern could be associated with dysfunctional mRGCs, most likely Brn-3b-positive mRGCs in CFP-D2 mice. 展开更多
关键词 pigmentary glaucoma Thyl-CFP-DBA/2J mouse retinal ganglion cells melanopsin-expressing retinal ganglion cells depression
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Morphological changes in Schlemm's canal in treated and newly diagnosed untreated glaucomatous eyes
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作者 SHI Guo Hua FU Ling Ling +2 位作者 LI Xi Qi JIANG Chun Hui ZHANG Yu Dong 《Science China(Life Sciences)》 SCIE CAS 2014年第12期1213-1217,共5页
A custom built 1310 nm center wavelength swept source optical coherence tomography instrument was used to measure morphological changes in treated and newly diagnosed untreated glaucomatous human Schlemm’s canal(SC).... A custom built 1310 nm center wavelength swept source optical coherence tomography instrument was used to measure morphological changes in treated and newly diagnosed untreated glaucomatous human Schlemm’s canal(SC).Thirty-seven primary open-angle glaucoma patients were divided into two groups depending on the patients having been treated or not.The statistical results showed that there were significant differences between the treated and untreated groups’SC areas(treated,7935.6875±680.003μm2;untreated,3890.71875±871.49844μm2;P<0.001),the circumferences(treated,580.37891±44.96529μm;untreated,381.9026±41.22123μm;P<0.001),and the long diameters(treated,272.87806±25.7254μm;untreated,185.24047±19.72786μm;P<0.001).We hypothesize that,after drug treatment,the SC will expand and the morphometric values especially the areas will become larger,thus helping to reduce intraocular pressure. 展开更多
关键词 OPHTHALMOLOGY glaucomatous Schlemm's canal MORPHOMETRY
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