Objective Bromocriptine and other dopamine D2 receptor agonists can affect a range of behaviors in nonhuman primates, particularly those behaviors associated with motor and mental function, such as suppressant behavio...Objective Bromocriptine and other dopamine D2 receptor agonists can affect a range of behaviors in nonhuman primates, particularly those behaviors associated with motor and mental function, such as suppressant behaviors and hallucinatory-like behaviors in monkeys. Besides bromocriptine, the dysfunction of the rapid eye movement sleep （REM） mechanism may also contribute to hallucinations. Dissociation of wakefulness, REM, and non-REM （NREM） can cause a series of psychotic symptoms. Methods In present study, we simultaneously recorded auditory evoked potentials （AEP） from five cerebral regions in monkeys during normal and psychotomimetic states to investigate and compare state-dependent changes in AEE Results Phase reversal of peak-to-baseline amplitude of 250 ms component （PBA250） in dorsolateral prefrontal cortex was common characteristic of hallucinatory-like and REM, and that hallucinatory-like and REM shared the equivalent modulatory orderliness of the PBA250 in dorsolateral prefrontal cortex. This result suggests that hallucinatory-like and REM share an equivalent electrophysiological modulatory in dorsolateral prefrontal cortex. Conclusion Our results reveal that emergence of the N250 in dorsolateral prefrontal cortex is an exclusive marker that may help to discern whether hallucinatory-like behaviors is exhibited, which suggests that dorsolateral prefrontal cortex may be the most pivotal region for exhibition of hallucinatory-like behaviors.展开更多
OBJECTIVE: To investigate the effects of the Sini San at different doses on each sleeping state[slow-wave sleep 1(SWS1), slow-wave sleep 2(SWS2), rapid-eye-movement(REM), wakefulness(W)] in insomnia rats and to identi...OBJECTIVE: To investigate the effects of the Sini San at different doses on each sleeping state[slow-wave sleep 1(SWS1), slow-wave sleep 2(SWS2), rapid-eye-movement(REM), wakefulness(W)] in insomnia rats and to identify its mode of ac-tion for improving sleep.METHODS: The insomnia rats were randomly divided into a high-, medium- or low-dose group of Sini San(equal to crude drug 8.8, 4.4, or 2.2 g/kg, respectively) for seven consecutive days.RESULTS: Compared with pre-administration,SWS2 was significantly increased after administration of the low dose. Compared with pre-administration, W was significantly decreased and SWS1,SWS2, and the total sleeping time(TST) were markedly increased after administration of the medium dose. Compared with pre-administration, W was significantly decreased and SWS1, SWS2, rapid-eye-movement sleep, and TST were significantly longer after administration of the high dose. The effects of Sini San on sleep-wake cycle are dose-dependent.CONCLUSION: The results suggest that Sini San extends SWS1 and SWS2, which increases the total sleeping time.展开更多
Objective:To investigate gender difference in the effects of daytime sleep on item and source memories,which are dissociable elements of declarative memory,and the effects of sleep on recollection and familiarity,whic...Objective:To investigate gender difference in the effects of daytime sleep on item and source memories,which are dissociable elements of declarative memory,and the effects of sleep on recollection and familiarity,which are two processes underlying recognition. Methods:Participants saw a series of pictures with either blue or red background,and were then given a pretest for item and source memories. Then males and females respectively were randomly assigned either to a wake or a sleep condition. In the wake condition,participants remained awake until the posttest;in the sleep condition,participants slept for 1 h until awakened and asked to remain awake until the posttest. Results:Daytime sleep contributed to retention of source memory rather than item memory in females,whereas males undergoing daytime sleep had a trend towards increased familiarity. For females,however,neither recollection nor familiarity appeared to be influenced by daytime sleep. Conclusion:The mechanism underlying gender difference may be linked with different memory traces resulting from different encoding strategies,as well as with different electrophysiological changes during daytime sleep.展开更多
基金supported by the grants from the Program of Chinese Acad emy of Sciences(No.KJCX1-07)National Basic Research Priorities Programme of China(No.G1999054000)+3 种基金Huo Yingdong Grant(No.91038)National Natural Science Foundation of China(No.30200068)Famous Doctors Program of Health Department of Guangdong Province(No.21)International Collaboration Key Project from the National Natural Science Foundation of China(No.30420120048).
文摘Objective Bromocriptine and other dopamine D2 receptor agonists can affect a range of behaviors in nonhuman primates, particularly those behaviors associated with motor and mental function, such as suppressant behaviors and hallucinatory-like behaviors in monkeys. Besides bromocriptine, the dysfunction of the rapid eye movement sleep （REM） mechanism may also contribute to hallucinations. Dissociation of wakefulness, REM, and non-REM （NREM） can cause a series of psychotic symptoms. Methods In present study, we simultaneously recorded auditory evoked potentials （AEP） from five cerebral regions in monkeys during normal and psychotomimetic states to investigate and compare state-dependent changes in AEE Results Phase reversal of peak-to-baseline amplitude of 250 ms component （PBA250） in dorsolateral prefrontal cortex was common characteristic of hallucinatory-like and REM, and that hallucinatory-like and REM shared the equivalent modulatory orderliness of the PBA250 in dorsolateral prefrontal cortex. This result suggests that hallucinatory-like and REM share an equivalent electrophysiological modulatory in dorsolateral prefrontal cortex. Conclusion Our results reveal that emergence of the N250 in dorsolateral prefrontal cortex is an exclusive marker that may help to discern whether hallucinatory-like behaviors is exhibited, which suggests that dorsolateral prefrontal cortex may be the most pivotal region for exhibition of hallucinatory-like behaviors.
基金Supported by Hippocampus Neural Coding Mechanism Research on Sini San Intervention Sleep Disorders of PTSD in Myospalax cansus from the National Natural Science Foundation(No.81460611)Study on Sini San for regulation of expression of proteins of drosophila brain of sleep deprivation of Gansu Province Natural Science Foundation(No.145RJZA076)+3 种基金Fundamental Research Funds for the Gansu Provincial Department of Finance Universities(No.2013-2)Mechanisms of hippocampal neurons based on Jiawei Sini San intervention coding mode PTSD sleep disordersMinistry of Education,Sini San for intervention of sleep deprivation in drosophila Based nano-2D-LC/MS technology of Science and Technology Key Project(No.212186)Proteomics and effective substance basic of Sini San for improving sleep of Gansu Province Natural Science Foundation(No.1010RJZA212)
文摘OBJECTIVE: To investigate the effects of the Sini San at different doses on each sleeping state[slow-wave sleep 1(SWS1), slow-wave sleep 2(SWS2), rapid-eye-movement(REM), wakefulness(W)] in insomnia rats and to identify its mode of ac-tion for improving sleep.METHODS: The insomnia rats were randomly divided into a high-, medium- or low-dose group of Sini San(equal to crude drug 8.8, 4.4, or 2.2 g/kg, respectively) for seven consecutive days.RESULTS: Compared with pre-administration,SWS2 was significantly increased after administration of the low dose. Compared with pre-administration, W was significantly decreased and SWS1,SWS2, and the total sleeping time(TST) were markedly increased after administration of the medium dose. Compared with pre-administration, W was significantly decreased and SWS1, SWS2, rapid-eye-movement sleep, and TST were significantly longer after administration of the high dose. The effects of Sini San on sleep-wake cycle are dose-dependent.CONCLUSION: The results suggest that Sini San extends SWS1 and SWS2, which increases the total sleeping time.
基金supported partially by the National Basic Research Program (973) of China (No. 2006CB303101)the National Natural Science Foundation of China (No. 90820305)
文摘Objective:To investigate gender difference in the effects of daytime sleep on item and source memories,which are dissociable elements of declarative memory,and the effects of sleep on recollection and familiarity,which are two processes underlying recognition. Methods:Participants saw a series of pictures with either blue or red background,and were then given a pretest for item and source memories. Then males and females respectively were randomly assigned either to a wake or a sleep condition. In the wake condition,participants remained awake until the posttest;in the sleep condition,participants slept for 1 h until awakened and asked to remain awake until the posttest. Results:Daytime sleep contributed to retention of source memory rather than item memory in females,whereas males undergoing daytime sleep had a trend towards increased familiarity. For females,however,neither recollection nor familiarity appeared to be influenced by daytime sleep. Conclusion:The mechanism underlying gender difference may be linked with different memory traces resulting from different encoding strategies,as well as with different electrophysiological changes during daytime sleep.
