目的 研究以低压氧方法建立的阻塞性睡眠呼吸暂停综合征（OS／kS）模型小型猪的睡眠生理。方法 12只成年雄性小型猪随机分为模型组（A）、对照组（B）。A组置于双室低压氧舱一室，仓内压力约53．9kPa，氧浓度10％-11．2％；B组置于低压...目的 研究以低压氧方法建立的阻塞性睡眠呼吸暂停综合征（OS／kS）模型小型猪的睡眠生理。方法 12只成年雄性小型猪随机分为模型组（A）、对照组（B）。A组置于双室低压氧舱一室，仓内压力约53．9kPa，氧浓度10％-11．2％；B组置于低压仓二室，舱内压力为海平面气压，氧浓度21％。两组每天均入仓6h，连续22天。第23天，小型猪行睡眠监测，记录其胸、腹部运动，呼吸气流，心率，血氧饱和度（SpO2）5项指标，软件分析数据得出呼吸暂停低通气指数（AHI）、低通气指数（HI）、平均Spoz。之后处死小型猪，取其咽部组织行病理检查。结果A组与B组比较AHI（16．1±8.3 vs 2．3±1．6）、HI（4．3±3.1 vs 1．3±1．0）、SpQ（86．7±3．6 vs 94．5±1．8）均有显著差异（P〈0．05）。A组上皮组织增生伴角化，黏膜下层水肿、纤维组织增生，肌肉萎缩、横纹不清，肌间脂肪增生。B组咽部黏膜为复层扁平上皮，黏膜下层薄，肌层横纹清，肌间脂肪少。结论 低压氧方法建立的OSAS模型小型猪睡眠生理变化规律与人OSAS患者类似。展开更多
Objective To explore the behavioral and physiologic changes of sleep in the heroin addicts. Methods Sleep behavior and all night polysomnographic recording were performed in 32 heroin addict and 21 normal controls. Re...Objective To explore the behavioral and physiologic changes of sleep in the heroin addicts. Methods Sleep behavior and all night polysomnographic recording were performed in 32 heroin addict and 21 normal controls. Results ①Compared with control group, the incidences of sleep continuity disturbance, easy wake, hypersomnia and difficulty falling asleep in patient group weer significantly increased (P < 0.05 — 0.01 ). ②REM latency was shorter in patients than that in controls; and slow wave sleep, steeper, sleep maintenance in patient group were markedly decreased (P < 0.05 — 0.01 ). While the awake dutation, arousal times, sleep stage, tate of awake/asleep were increased in patient group ( P <0.05—0.01);The average duration in Ⅲ and Ⅳ stage was [(9.1 ± 1.3)%] and the duration in Ⅰ stage was [ (14.8 ± 2.8)% ]. Conclusions It is consistent the behavioral dimmers of sleep with the physiologic dysfunction in heroin addicts, and the pathogenesis of sleep disturbance may result from the etiology of heroin addicts. Heroin addicts have severe problems in sleep after detoxification, It is very important to pay more attention to the improvement of sleep quahity and psychological treatment of heroin addiets during detoxiiication.展开更多
文摘目的 研究以低压氧方法建立的阻塞性睡眠呼吸暂停综合征（OS／kS）模型小型猪的睡眠生理。方法 12只成年雄性小型猪随机分为模型组（A）、对照组（B）。A组置于双室低压氧舱一室，仓内压力约53．9kPa，氧浓度10％-11．2％；B组置于低压仓二室，舱内压力为海平面气压，氧浓度21％。两组每天均入仓6h，连续22天。第23天，小型猪行睡眠监测，记录其胸、腹部运动，呼吸气流，心率，血氧饱和度（SpO2）5项指标，软件分析数据得出呼吸暂停低通气指数（AHI）、低通气指数（HI）、平均Spoz。之后处死小型猪，取其咽部组织行病理检查。结果A组与B组比较AHI（16．1±8.3 vs 2．3±1．6）、HI（4．3±3.1 vs 1．3±1．0）、SpQ（86．7±3．6 vs 94．5±1．8）均有显著差异（P〈0．05）。A组上皮组织增生伴角化，黏膜下层水肿、纤维组织增生，肌肉萎缩、横纹不清，肌间脂肪增生。B组咽部黏膜为复层扁平上皮，黏膜下层薄，肌层横纹清，肌间脂肪少。结论 低压氧方法建立的OSAS模型小型猪睡眠生理变化规律与人OSAS患者类似。
文摘Objective To explore the behavioral and physiologic changes of sleep in the heroin addicts. Methods Sleep behavior and all night polysomnographic recording were performed in 32 heroin addict and 21 normal controls. Results ①Compared with control group, the incidences of sleep continuity disturbance, easy wake, hypersomnia and difficulty falling asleep in patient group weer significantly increased (P < 0.05 — 0.01 ). ②REM latency was shorter in patients than that in controls; and slow wave sleep, steeper, sleep maintenance in patient group were markedly decreased (P < 0.05 — 0.01 ). While the awake dutation, arousal times, sleep stage, tate of awake/asleep were increased in patient group ( P <0.05—0.01);The average duration in Ⅲ and Ⅳ stage was [(9.1 ± 1.3)%] and the duration in Ⅰ stage was [ (14.8 ± 2.8)% ]. Conclusions It is consistent the behavioral dimmers of sleep with the physiologic dysfunction in heroin addicts, and the pathogenesis of sleep disturbance may result from the etiology of heroin addicts. Heroin addicts have severe problems in sleep after detoxification, It is very important to pay more attention to the improvement of sleep quahity and psychological treatment of heroin addiets during detoxiiication.
