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大鼠急性大强度运动时血浆睾酮变化及其机理
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作者 陆耀飞 刘无逸 赵淮北 《上海体育学院学报》 CSSCI 北大核心 1997年第4期40-44,共5页
采用实验方法,对两组大鼠大强度运动时血浆睾酮变化及其机理进行探析。结果显示,运动组大鼠的血浆睾酮及睾丸中17β-羟类固醇脱氢酶活性浓度显著高于对照组,两组的血浆黄体生成素和红细胞压积无显著差异。提示,经8周耐力训练的大鼠,急... 采用实验方法,对两组大鼠大强度运动时血浆睾酮变化及其机理进行探析。结果显示,运动组大鼠的血浆睾酮及睾丸中17β-羟类固醇脱氢酶活性浓度显著高于对照组,两组的血浆黄体生成素和红细胞压积无显著差异。提示,经8周耐力训练的大鼠,急性大强度运动后血浆睾酮升高。这可能是睾丸中合成、分泌增加的结果。 展开更多
关键词 大强度运动 血浆睾酮 睾丸机理
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EXPRESSION OF A TELOMERASE-ASSOCIATED GENE IN NORMAL, ATROPHIC ,AND TUMOROUS TESTES 被引量:2
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作者 Fang Mei Bo Zhang Zhi-wei Tang Lin Hou 《Chinese Medical Sciences Journal》 CAS CSCD 2005年第3期217-220,共4页
Objective To evaluate the expression of telomerase transcriptional elements-interacting factor (TEIF) in human testis under different status and its relation with human telomerase reverse transcriptase (hTERT) exp... Objective To evaluate the expression of telomerase transcriptional elements-interacting factor (TEIF) in human testis under different status and its relation with human telomerase reverse transcriptase (hTERT) expression. Methods Specific antisera against TEIF were generated by immunization of rabbits with purified recombinated partial TEIF. Samples were assigned to three groups according to their pathological types, including 16 normal testes, 8 atrophic testes, and 6 testicular seminomas. They were subjected to immunohistochemical staining of TEIF and hTERT. Results from both TEIF and hTERT were analyzed semi-quantitatively and compared. The expressions of TEIF and hTERT were detected in all samples of normal, atrophic testes, and seminomas. No differences of TEIF expressions among these three groups were observed (P 〉 0.05). On the contrary, the expressions of hTERT were significantly lower in atrophic testes compared with those of normal testes and seminomas (both P 〈 0.05). Nevertheless, co-expressions of TEIF with hTERT were revealed to be in normal and malignant cases (P 〈 0.05) but not in atrophic testes, which generally presented TEIF expression. The cellular distributions of both proteins were similar and mainly in spermatocytes and some Sertoli cells, while were all negative in the interstitial cells and other stromal cells. Conclusion The uniform expressions of TEIF in all these specimens suggest that it may be a marker of testis and its related diseases. The strong expression of hTERT in normal testes and testicular seminomas comparing with the low expression in atrophic testes may suggest a role for telomerase in maintaining proliferation of germ cells. 展开更多
关键词 telomerase transcriptional elements-interacting factor human telomerase reverse transcriptase IMMUNOHISTOCHEMISTRY TESTIS
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