To semantically integrate heterogeneous resources and provide a unified intelligent access interface, semantic web technology is exploited to publish and interlink machineunderstandable resources so that intelligent s...To semantically integrate heterogeneous resources and provide a unified intelligent access interface, semantic web technology is exploited to publish and interlink machineunderstandable resources so that intelligent search can be supported. TCMSearch, a deployed intelligent search engine for traditional Chinese medicine （TCM）, is presented. The core of the system is an integrated knowledge base that uses a TCM domain ontology to represent the instances and relationships in TCM. Machine-learning techniques are used to generate semantic annotations for texts and semantic mappings for relational databases, and then a semantic index is constructed for these resources. The major benefit of representing the semantic index in RDF/OWL is to support some powerful reasoning functions, such as class hierarchies and relation inferences. By combining resource integration with reasoning, the knowledge base can support some intelligent search paradigms besides keyword search, such as correlated search, semantic graph navigation and concept recommendation.展开更多
OBJECTIVE:To evaluate the efficacy and safety of Xuefuzhuyu decoction for hyperlipidemia.METHODS:Randomized clinical trials on hyperlipidemia treated by Xuefuzhuyu decoction,either alone or with Western Medicine,were ...OBJECTIVE:To evaluate the efficacy and safety of Xuefuzhuyu decoction for hyperlipidemia.METHODS:Randomized clinical trials on hyperlipidemia treated by Xuefuzhuyu decoction,either alone or with Western Medicine,were searched in electronic databases.Databases searched were:MEDLINE,Allied and Complementary Medicine Database,EMBASE,The Cochrane Library 2013(Issue4),China National Knowledge Infrastructure Database,Chinese Biomedical Literature Database,and Wanfang Database up to 2 May,2013.Study selection,data extraction,quality assessment,and data analysis were conducted according to the Cochranestandards.RESULTS:Six randomized clinical trials involving748 patients(373 patients in the treatment group,375 patients in the control group)were included in the analysis.The studies were of low methodological quality.Meta-analysis indicated that the effect of Xuefuzhuyu decoction on hyperlipidemia was better than that in the control group[n=748,OR=5.07,95%CI(3.40,7.58),P<0.01].Weighted mean differencesin total cholesterol,low-densitylipoprotein cholesterol,triglycerides,and high-density lipoprotein cholesterol were﹣0.79,﹣0.74,﹣0.44,0.16,respectively,and Meta-analysis revealed that the treatment group was better than the control group with 95%CI(﹣1.21,﹣0.36),(﹣0.94,﹣0.55),(﹣0.77,﹣0.11),(0.04,0.27),respectively(all P<0.05).Some adverse events in evaluated studies wererecorded.CONCLUSION:Xuefuzhuyu decoction may be effective for treating hyperlipidemia.The studies we analyzed were of low methodological quality,which indicates that the above findings should be considered cautiously.Therefore,more strictly designed large-scale randomized clinical trials are needed to evaluate the efficacy of Xuefuzhuyu decoction in hyperlipidemia.展开更多
基金Program for Changjiang Scholars and Innovative Research Team in University (NoIRT0652)the National High Technology Research and Development Program of China (863 Program) ( No2006AA01A123)
文摘To semantically integrate heterogeneous resources and provide a unified intelligent access interface, semantic web technology is exploited to publish and interlink machineunderstandable resources so that intelligent search can be supported. TCMSearch, a deployed intelligent search engine for traditional Chinese medicine （TCM）, is presented. The core of the system is an integrated knowledge base that uses a TCM domain ontology to represent the instances and relationships in TCM. Machine-learning techniques are used to generate semantic annotations for texts and semantic mappings for relational databases, and then a semantic index is constructed for these resources. The major benefit of representing the semantic index in RDF/OWL is to support some powerful reasoning functions, such as class hierarchies and relation inferences. By combining resource integration with reasoning, the knowledge base can support some intelligent search paradigms besides keyword search, such as correlated search, semantic graph navigation and concept recommendation.
基金Supported by National Natural Science Foundation of China(the Inflammatory Mechanism of Renal Damage in Hyperlipidemia Rat After Myocardial Ischemia and the Intevention of Activating Blood and Dissolving Stasis.No.81072924)
文摘OBJECTIVE:To evaluate the efficacy and safety of Xuefuzhuyu decoction for hyperlipidemia.METHODS:Randomized clinical trials on hyperlipidemia treated by Xuefuzhuyu decoction,either alone or with Western Medicine,were searched in electronic databases.Databases searched were:MEDLINE,Allied and Complementary Medicine Database,EMBASE,The Cochrane Library 2013(Issue4),China National Knowledge Infrastructure Database,Chinese Biomedical Literature Database,and Wanfang Database up to 2 May,2013.Study selection,data extraction,quality assessment,and data analysis were conducted according to the Cochranestandards.RESULTS:Six randomized clinical trials involving748 patients(373 patients in the treatment group,375 patients in the control group)were included in the analysis.The studies were of low methodological quality.Meta-analysis indicated that the effect of Xuefuzhuyu decoction on hyperlipidemia was better than that in the control group[n=748,OR=5.07,95%CI(3.40,7.58),P<0.01].Weighted mean differencesin total cholesterol,low-densitylipoprotein cholesterol,triglycerides,and high-density lipoprotein cholesterol were﹣0.79,﹣0.74,﹣0.44,0.16,respectively,and Meta-analysis revealed that the treatment group was better than the control group with 95%CI(﹣1.21,﹣0.36),(﹣0.94,﹣0.55),(﹣0.77,﹣0.11),(0.04,0.27),respectively(all P<0.05).Some adverse events in evaluated studies wererecorded.CONCLUSION:Xuefuzhuyu decoction may be effective for treating hyperlipidemia.The studies we analyzed were of low methodological quality,which indicates that the above findings should be considered cautiously.Therefore,more strictly designed large-scale randomized clinical trials are needed to evaluate the efficacy of Xuefuzhuyu decoction in hyperlipidemia.
