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矿化胶原材料的制备、调控及矿化机制研究进展
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作者 田振华 赵文杰 +1 位作者 高盼盼 何静瑄 《陕西科技大学学报》 北大核心 2023年第6期121-130,共10页
骨修复材料是当前临床应用需求量最大的生物医用材料之一.Ⅰ型胶原作为人体的主要结构蛋白,是骨组织的主要成分.胶原纤维所具有的独特四分之一错列结构能够引导纳米粒子沉积而实现矿化,因此常作为模板制备矿化胶原材料以模拟骨骼的多级... 骨修复材料是当前临床应用需求量最大的生物医用材料之一.Ⅰ型胶原作为人体的主要结构蛋白,是骨组织的主要成分.胶原纤维所具有的独特四分之一错列结构能够引导纳米粒子沉积而实现矿化,因此常作为模板制备矿化胶原材料以模拟骨骼的多级微纳米结构,应用于骨修复领域.全文综述了矿化胶原材料的种类及制备,重点阐述了胶原纤维的矿化机制及调控因素,并简要展望了矿化胶原材料的发展前景及面临的挑战,为矿化胶原材料的制备及矿化机制的探索提供参考. 展开更多
关键词 矿化胶原材料 种类 制备 机制 调控因素
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Mineralization regulation and biological influence of bioactive glass-collagen-phosphatidylserine composite scaffolds 被引量:1
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作者 YANG ChunRong WANG YingJun CHEN XiaoFeng 《Science China(Life Sciences)》 SCIE CAS 2012年第3期236-240,共5页
Biomimetic scaffolds are appealing products for the repair of bone defects using tissue engineering strategies.In the present study,novel biomimetic composite scaffolds,with similar properties to natural bone,were pre... Biomimetic scaffolds are appealing products for the repair of bone defects using tissue engineering strategies.In the present study,novel biomimetic composite scaffolds,with similar properties to natural bone,were prepared,blended and cross-linked with bioactive glass,type I collagen and phosphatidylserine.When exposed to cell culture solution in the absence of a cellular source,the composite scaffolds form crystals with octahedral structure.These crystals are similar to the products derived from MC3T3-E1 cell mineralization within the composite scaffolds,with respect to both composition and morphology.Furthermore,crystals with octahedral structure were observed to develop into plate-like hydroxyapatite.The bio-mineralization behavior of the composite scaffolds is likely influenced by inorganic components.Finally,a rabbit tibia defect model shows that the highly bioactive properties of the investigated composites result in excellent bone repair. 展开更多
关键词 composite SCAFFOLD cell bio-mineralization REGULATION
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