Hepatitis C virus （HCV） is a major cause of chronic liver disease, cirrhosis and hepatocellular carcinoma （HCC）. In man, the pathobiological changes associated with HCV infection have been attributed to both the i...Hepatitis C virus （HCV） is a major cause of chronic liver disease, cirrhosis and hepatocellular carcinoma （HCC）. In man, the pathobiological changes associated with HCV infection have been attributed to both the immune system and direct viral cytopathic effects. Until now, the lack of simple culture systems to infect and propagate the virus has hampered progress in understanding the viral life cycle and pathogenesis of HCV infection, including the molecular mechanisms implicated in HCV-induced HCC. This clearly demonstrates the need to develop small animal models for the study of HCV-associated pathogenesis. This review describes and discusses the development of new HCV animal models to study viral infection and investigate the direct effects of viral protein expression on liver disease.展开更多
Although the upwind configuration is more popular in the field of wind energy, the downwind one is a promising type for the offshore wind energy due to its special advantages. Different configurations have different a...Although the upwind configuration is more popular in the field of wind energy, the downwind one is a promising type for the offshore wind energy due to its special advantages. Different configurations have different aerodynamic performance and it is important to predict the performance of both downwind and upwind configurations accurately for designing and developing more reliable wind turbines. In this paper, a numerical investigation on the aerodynamic performance of National Renewable Energy Laboratory （NREL） phase V1 wind turbine in downwind and upwind configurations is presented. The open source toolbox OpenFOAM coupled with arbitrary mesh interface （AMI） method is applied to tackle rotating problems of wind turbines. Two 3D numerical models of NREL phase VI wind turbine with downwind and upwind configurations under four typical working conditions of incoming wind velocities are set up for the study of different unsteady characteristics of the downwind and upwind configurations, respectively. Numerical results of wake vortex structure, time histories of thrust, pressure distribution on the blade and limiting streamlines which can be used to identify points of separation in a 3D flow are presented. It can be concluded that thrust reduction due to blade-tower interaction is small for upwind wind turbines but relatively large for downwind wind turbines and attention should be paid to the vibration at a certain frequency induced by the cyclic reduction for both configurations. The results and conclusions are helpful to analyze the different aerodynamic performance of wind turbines between downwind and upwind configurations, providing useful references for practical design of wind turbine.展开更多
Rain-wind-induced vibration of cable was studied based on previous research achievements. According to the quasi-steady assumption, the governing equation of vertical motion of the cable was derived and the criterion ...Rain-wind-induced vibration of cable was studied based on previous research achievements. According to the quasi-steady assumption, the governing equation of vertical motion of the cable was derived and the criterion for unstable motion and occurrence mechanism was studied. A comparison was performed between the oscillation responses of the stay cable obtained from calculated model and previous results. The results indicate that the analysis model can reflect the main characteristics of wind-rain-induced vibrationt of the cable which is amplitude- and velocity-restricted, and it is probably related with the periodic vortex shedding of wake flow. It is essential for the occurrence of rain-wind-induced or wind-induced vibration of cable that the derivative of lift coefficient with respect to transient angle of attack is less than zero. When rain-wind-induced vibration occurs, the aerodynamic force has a dual function for the vibration, and the maximum amplitude of stayed-cable is determined by the relative value of aerodynamic exciting force and aerodynamic damping force.展开更多
The price of fuel oil continues to rise, decreased supplies oil at the other side, both factors increase the interest of researchers to conduct research related to fuel efficiency. Therefore the aim of this study is t...The price of fuel oil continues to rise, decreased supplies oil at the other side, both factors increase the interest of researchers to conduct research related to fuel efficiency. Therefore the aim of this study is to improve the efficiency fuel of diesel engine using fuel filter. The method used for the research is testing the most efficient fuel filters made of coil wire coil winding 5,000, the three distinguished from the coil core diameter of 44.5, 28.5 and 17.5 mm in diesel engine. The performance test was conducted from 1,100 rpm to 1,700 rpm, the throttle opening of 30%-60%. The first testing was done by creating a constant speed 1,500 rpm and throttle opening varies from 30% to 60%, further testing is done by varying the rpm start from 1,100 rpm to 1,700 rpm to make constant valve 40% and 60%.展开更多
The highly loaded turbine blades are able to reduce both the number of blades and the stages of turbojet-engines. In this study, PIV(Particle Image Velocimetry) method is used for the measurements of the secondary flo...The highly loaded turbine blades are able to reduce both the number of blades and the stages of turbojet-engines. In this study, PIV(Particle Image Velocimetry) method is used for the measurements of the secondary flow in ultra-highly loaded turbine blade cascades. The results obtained by the PIV method clearly show the complicated behavior of the secondary flow in the cascade. The horseshoe vortex and the passage vortex are observed inside the cascade. Moreover, the wake generated by the accumulation of the low energy fluid by the passage vortex near the suction side and that discharged toward downstream of the trailing edge has been recognized.展开更多
Pulse detonation engine (PDE) is expected for a next-generation propulsion system. PDE is a promising engine that can generates power and thrust by using intermittent detonation. Promotion of deflagration to detonatio...Pulse detonation engine (PDE) is expected for a next-generation propulsion system. PDE is a promising engine that can generates power and thrust by using intermittent detonation. Promotion of deflagration to detonation transition (below DDT) is a key issue to realize this system. PDE has experimentally been investigated, and it was confirmed that detonation tubes with U-shaped bends are useful for fast DDT. However, the mechanism of DDT promotion due to U-bends has not been well clarified. In the present study, the influence of a U-bend on detona-tion wave propagation is researched with computational fluid dynamics (CFD). The numerical results show that detonation wave disappears once near the U-bend inlet and restarts after passing through it. In addition, it was found that the use of the U-bend with small channel width and curvature radius can induce fast DDT.展开更多
The application and fundamental study on turbulent premixed combustion of hydrogen enriched natural gas is reviewed in this paper.Discussions include the combustion characteristics of direct injection engine fueled wi...The application and fundamental study on turbulent premixed combustion of hydrogen enriched natural gas is reviewed in this paper.Discussions include the combustion characteristics of direct injection engine fueled with hydrogen enriched natural gas,visualization study of direct injection combustion of hydrogen enriched natural gas using a constant volume vessel,and the fundamental study of turbulent premixed combustion of hydrogen enriched natural gas.The effect of additional hydrogen on the combustion process of natural gas engine is investigated from the fundamental view of the interaction between combustion reaction and turbulent flow.展开更多
The total efficiency of power plants depends on the energy conversion in a combustor and a turbine .Considerably higher energy transfer rates can be obtained from a pulsed combustion.but unsteady flow of a single jet ...The total efficiency of power plants depends on the energy conversion in a combustor and a turbine .Considerably higher energy transfer rates can be obtained from a pulsed combustion.but unsteady flow of a single jet combustor reduces the turbine efficiency.Therefore.two pulse combustors were set in parallel and connected to a settling chamber that supplies a flow with constant pressure to the turbine.The aim of investigations presented here is a demonstration of technical feasibility for industrial applications and to show the benefits obtained from the pulse combustors.展开更多
Today,with nonstop improvement in computational power,Large-Eddy Simulation(LES) is a high demanding research tool for predicting engineering flows.Such flows on high pressure condition like diesel engines is extensiv...Today,with nonstop improvement in computational power,Large-Eddy Simulation(LES) is a high demanding research tool for predicting engineering flows.Such flows on high pressure condition like diesel engines is extensively employed in ground and marine transportation,oblige the designer to control and predict toxic pollutants,while maintaining or improving their high thermal efficiency.This becomes one of the main challenging issues in decades.In the present work,numerical investigation of diffusion flame dynamics is performed in the near-field of high-Reynolds jet flow on high pressure condition encountered in diesel engine applications.This work discusses the implementation of Partially Stirred Reactor(PaSR) combustion model by the approaches of large eddy simulation(LES).The simulation results show that LES,in comparison with Reynolds-Averaged Navier-Stokes(RANS) simulation predicts and captures transient phenomena very well.These phenomena such as unsteadiness and curvature are inherent in the near-field of high Reynolds diffusion flame.The outcomes of this research are compared and validated by other researchers' results.Detailed comparisons of the statistics show good agreement with the corresponding experiments.展开更多
文摘Hepatitis C virus （HCV） is a major cause of chronic liver disease, cirrhosis and hepatocellular carcinoma （HCC）. In man, the pathobiological changes associated with HCV infection have been attributed to both the immune system and direct viral cytopathic effects. Until now, the lack of simple culture systems to infect and propagate the virus has hampered progress in understanding the viral life cycle and pathogenesis of HCV infection, including the molecular mechanisms implicated in HCV-induced HCC. This clearly demonstrates the need to develop small animal models for the study of HCV-associated pathogenesis. This review describes and discusses the development of new HCV animal models to study viral infection and investigate the direct effects of viral protein expression on liver disease.
基金Foundation item： Supported by the National Natural Science Foundation of China （Grant Nos. 51379125, 51411130131, 11432009）, the National Key Basic Research Development Plan （973 Plan） Project of China （Grant No. 2013CB036103）, High Technology of Marine Research Project of the Ministry of Industry and Information Technology of China, ABS（China）, and the Program for Professor of Special Appointment （Eastern Scholar） at Shanghai Institutions of Higher Learning （Grant No. 2013022）.
文摘Although the upwind configuration is more popular in the field of wind energy, the downwind one is a promising type for the offshore wind energy due to its special advantages. Different configurations have different aerodynamic performance and it is important to predict the performance of both downwind and upwind configurations accurately for designing and developing more reliable wind turbines. In this paper, a numerical investigation on the aerodynamic performance of National Renewable Energy Laboratory （NREL） phase V1 wind turbine in downwind and upwind configurations is presented. The open source toolbox OpenFOAM coupled with arbitrary mesh interface （AMI） method is applied to tackle rotating problems of wind turbines. Two 3D numerical models of NREL phase VI wind turbine with downwind and upwind configurations under four typical working conditions of incoming wind velocities are set up for the study of different unsteady characteristics of the downwind and upwind configurations, respectively. Numerical results of wake vortex structure, time histories of thrust, pressure distribution on the blade and limiting streamlines which can be used to identify points of separation in a 3D flow are presented. It can be concluded that thrust reduction due to blade-tower interaction is small for upwind wind turbines but relatively large for downwind wind turbines and attention should be paid to the vibration at a certain frequency induced by the cyclic reduction for both configurations. The results and conclusions are helpful to analyze the different aerodynamic performance of wind turbines between downwind and upwind configurations, providing useful references for practical design of wind turbine.
基金Project(51078170) supported by the National Natural Science Foundation of ChinaProject(10JDG097) supported by Jiangsu University Talents Funds,China
文摘Rain-wind-induced vibration of cable was studied based on previous research achievements. According to the quasi-steady assumption, the governing equation of vertical motion of the cable was derived and the criterion for unstable motion and occurrence mechanism was studied. A comparison was performed between the oscillation responses of the stay cable obtained from calculated model and previous results. The results indicate that the analysis model can reflect the main characteristics of wind-rain-induced vibrationt of the cable which is amplitude- and velocity-restricted, and it is probably related with the periodic vortex shedding of wake flow. It is essential for the occurrence of rain-wind-induced or wind-induced vibration of cable that the derivative of lift coefficient with respect to transient angle of attack is less than zero. When rain-wind-induced vibration occurs, the aerodynamic force has a dual function for the vibration, and the maximum amplitude of stayed-cable is determined by the relative value of aerodynamic exciting force and aerodynamic damping force.
文摘The price of fuel oil continues to rise, decreased supplies oil at the other side, both factors increase the interest of researchers to conduct research related to fuel efficiency. Therefore the aim of this study is to improve the efficiency fuel of diesel engine using fuel filter. The method used for the research is testing the most efficient fuel filters made of coil wire coil winding 5,000, the three distinguished from the coil core diameter of 44.5, 28.5 and 17.5 mm in diesel engine. The performance test was conducted from 1,100 rpm to 1,700 rpm, the throttle opening of 30%-60%. The first testing was done by creating a constant speed 1,500 rpm and throttle opening varies from 30% to 60%, further testing is done by varying the rpm start from 1,100 rpm to 1,700 rpm to make constant valve 40% and 60%.
文摘The highly loaded turbine blades are able to reduce both the number of blades and the stages of turbojet-engines. In this study, PIV(Particle Image Velocimetry) method is used for the measurements of the secondary flow in ultra-highly loaded turbine blade cascades. The results obtained by the PIV method clearly show the complicated behavior of the secondary flow in the cascade. The horseshoe vortex and the passage vortex are observed inside the cascade. Moreover, the wake generated by the accumulation of the low energy fluid by the passage vortex near the suction side and that discharged toward downstream of the trailing edge has been recognized.
文摘Pulse detonation engine (PDE) is expected for a next-generation propulsion system. PDE is a promising engine that can generates power and thrust by using intermittent detonation. Promotion of deflagration to detonation transition (below DDT) is a key issue to realize this system. PDE has experimentally been investigated, and it was confirmed that detonation tubes with U-shaped bends are useful for fast DDT. However, the mechanism of DDT promotion due to U-bends has not been well clarified. In the present study, the influence of a U-bend on detona-tion wave propagation is researched with computational fluid dynamics (CFD). The numerical results show that detonation wave disappears once near the U-bend inlet and restarts after passing through it. In addition, it was found that the use of the U-bend with small channel width and curvature radius can induce fast DDT.
基金supported by the National Natural Science Foundation of China(Grant Nos.51376004 and 51006080)the National Basic Research Program of China("973"Program)(Grant No.2013CB228406)
文摘The application and fundamental study on turbulent premixed combustion of hydrogen enriched natural gas is reviewed in this paper.Discussions include the combustion characteristics of direct injection engine fueled with hydrogen enriched natural gas,visualization study of direct injection combustion of hydrogen enriched natural gas using a constant volume vessel,and the fundamental study of turbulent premixed combustion of hydrogen enriched natural gas.The effect of additional hydrogen on the combustion process of natural gas engine is investigated from the fundamental view of the interaction between combustion reaction and turbulent flow.
文摘The total efficiency of power plants depends on the energy conversion in a combustor and a turbine .Considerably higher energy transfer rates can be obtained from a pulsed combustion.but unsteady flow of a single jet combustor reduces the turbine efficiency.Therefore.two pulse combustors were set in parallel and connected to a settling chamber that supplies a flow with constant pressure to the turbine.The aim of investigations presented here is a demonstration of technical feasibility for industrial applications and to show the benefits obtained from the pulse combustors.
文摘Today,with nonstop improvement in computational power,Large-Eddy Simulation(LES) is a high demanding research tool for predicting engineering flows.Such flows on high pressure condition like diesel engines is extensively employed in ground and marine transportation,oblige the designer to control and predict toxic pollutants,while maintaining or improving their high thermal efficiency.This becomes one of the main challenging issues in decades.In the present work,numerical investigation of diffusion flame dynamics is performed in the near-field of high-Reynolds jet flow on high pressure condition encountered in diesel engine applications.This work discusses the implementation of Partially Stirred Reactor(PaSR) combustion model by the approaches of large eddy simulation(LES).The simulation results show that LES,in comparison with Reynolds-Averaged Navier-Stokes(RANS) simulation predicts and captures transient phenomena very well.These phenomena such as unsteadiness and curvature are inherent in the near-field of high Reynolds diffusion flame.The outcomes of this research are compared and validated by other researchers' results.Detailed comparisons of the statistics show good agreement with the corresponding experiments.
