硅微条探测器热控制系统(Tracker thermo control system,TTCS)是阿尔法磁谱仪(Alpha magnetic spectrometer,AMS)内一个重要的子系统.其主要任务是将AMS-02内部硅微条探测器产生的热量传导到辐射板以排散到太空,并维持探测器内部温度...硅微条探测器热控制系统(Tracker thermo control system,TTCS)是阿尔法磁谱仪(Alpha magnetic spectrometer,AMS)内一个重要的子系统.其主要任务是将AMS-02内部硅微条探测器产生的热量传导到辐射板以排散到太空,并维持探测器内部温度高度稳定。为提高可靠性,TTCS运行过程监控采取了结合自保护机制的分层监控实现策略.首先介绍了TTCS系统总体架构及组成;在此基础上着重描述了TTCS监控硬件平台,并分析了分层监控策略的模型结构和功能分配,硬件实现的自保护机制(Health-guard)进一步提高了系统运行安全度,最后结合地面模拟测试平台,给出了系统运行测试结果.该监控策略已成功应用在TTCS原型件设计中.展开更多
In the fight against cancer, controlled drug delivery systems have emerged to enhance the therapeutic efficacy and safety of anti-cancer drugs. Among these systems, mesoporous silica nanoparticles （MSNs） with a func...In the fight against cancer, controlled drug delivery systems have emerged to enhance the therapeutic efficacy and safety of anti-cancer drugs. Among these systems, mesoporous silica nanoparticles （MSNs） with a functional surface possess obvious advantages and were thus rapidly developed for cancer treatment. Many stimuli-responsive materials, such as nanopartides, polymers, and inorganic materials, have been applied as caps and gatekeepers to control drug release from MSNs. This review presents an overview of the recent progress in the production of pH-responsive MSNs based on the pH gradient between normal tissues and the tumor microenvironment. Four main categories of gatekeepers can respond to acidic conditions. These categories will be described in detail.展开更多
This work provides a general method for preparing monodisperse, water-soluble and paramagnetic magnetic nanoparticles which are easy to be modified. Firstly, magnetic silica with core-shell structure was prepared acco...This work provides a general method for preparing monodisperse, water-soluble and paramagnetic magnetic nanoparticles which are easy to be modified. Firstly, magnetic silica with core-shell structure was prepared according to a previous work. Then, the magnetic silica was treated with alkali solution to afford magnetic nanoparticles. With the increase of calcination temperature for the preparation of magnetic silica, the crystallinity and the magnetic responsibility of magnetic silica strengthened, meanwhile, the corresponding magnetic nanoparticles kept monodisperse without any aggregation. The magnetic nanoparticles are comprised of cobalt ferrite and a silica coating. The silica coating on the cobalt ferrite facilitates the magnetic nanoparticles well-dissolved and monodisperse in water, and easilv modified.展开更多
MPI（multishot pellet injector） was imported from Russia about ten years ago. During the year＇s operation in HL-1M, most electrical equipments were repaired. Since the components are non-standard, so it is difficult...MPI（multishot pellet injector） was imported from Russia about ten years ago. During the year＇s operation in HL-1M, most electrical equipments were repaired. Since the components are non-standard, so it is difficult to maintain. To fueling experiment meet the requirement of in HL-2A. The power supplies of fast valve and a programmable controller for shooting pellets were developed.展开更多
文摘硅微条探测器热控制系统(Tracker thermo control system,TTCS)是阿尔法磁谱仪(Alpha magnetic spectrometer,AMS)内一个重要的子系统.其主要任务是将AMS-02内部硅微条探测器产生的热量传导到辐射板以排散到太空,并维持探测器内部温度高度稳定。为提高可靠性,TTCS运行过程监控采取了结合自保护机制的分层监控实现策略.首先介绍了TTCS系统总体架构及组成;在此基础上着重描述了TTCS监控硬件平台,并分析了分层监控策略的模型结构和功能分配,硬件实现的自保护机制(Health-guard)进一步提高了系统运行安全度,最后结合地面模拟测试平台,给出了系统运行测试结果.该监控策略已成功应用在TTCS原型件设计中.
基金supported by the Chinese Natural Science Foundation Project (Grant No. 30970784 and 81171455)a National Distinguished Young Scholars Grant (Grant No. 31225009) from the National Natural Science Foundation of China+5 种基金the National Key Basic Research Program of China (Grant No. 2009CB930200)the Chinese Academy of Sciences (CAS) ‘Hundred Talents Program’ (Grant No. 07165111ZX)the CAS Knowledge Innovation Program, and the State HighTech Development Plan (Grant No. 2012AA020804)the ‘Strategic Priority Research Program’ of the Chinese Academy of Sciences (Grant No. XDA09030301)NIH/NIMHD 8 G12 MD007597USAMRMC W81XWH-10-1-0767 grants
文摘In the fight against cancer, controlled drug delivery systems have emerged to enhance the therapeutic efficacy and safety of anti-cancer drugs. Among these systems, mesoporous silica nanoparticles （MSNs） with a functional surface possess obvious advantages and were thus rapidly developed for cancer treatment. Many stimuli-responsive materials, such as nanopartides, polymers, and inorganic materials, have been applied as caps and gatekeepers to control drug release from MSNs. This review presents an overview of the recent progress in the production of pH-responsive MSNs based on the pH gradient between normal tissues and the tumor microenvironment. Four main categories of gatekeepers can respond to acidic conditions. These categories will be described in detail.
基金Supported by the National Natural Science Foundation of China(20976013)
文摘This work provides a general method for preparing monodisperse, water-soluble and paramagnetic magnetic nanoparticles which are easy to be modified. Firstly, magnetic silica with core-shell structure was prepared according to a previous work. Then, the magnetic silica was treated with alkali solution to afford magnetic nanoparticles. With the increase of calcination temperature for the preparation of magnetic silica, the crystallinity and the magnetic responsibility of magnetic silica strengthened, meanwhile, the corresponding magnetic nanoparticles kept monodisperse without any aggregation. The magnetic nanoparticles are comprised of cobalt ferrite and a silica coating. The silica coating on the cobalt ferrite facilitates the magnetic nanoparticles well-dissolved and monodisperse in water, and easilv modified.
文摘MPI（multishot pellet injector） was imported from Russia about ten years ago. During the year＇s operation in HL-1M, most electrical equipments were repaired. Since the components are non-standard, so it is difficult to maintain. To fueling experiment meet the requirement of in HL-2A. The power supplies of fast valve and a programmable controller for shooting pellets were developed.
