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诱导生物合成金属硫蛋白减轻顺铂对小鼠的致死毒性 被引量:13
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作者 郭军华 徐卓立 +2 位作者 宋三泰 刘琴棣 吴德政 《癌症》 SCIE CAS CSCD 北大核心 1993年第6期476-479,共4页
本研究对比了预先给予小鼠多种无机和有机含金属(Zn,Se,Ge,Bi和As)药物及中药十全大补膏等对顺铂致死毒性的影响。结果表明除复方甘铋镁、氧化锗及十全大补膏外,其余药物对顺铂的致死毒性均有一定保护作用。尤其是甘草锌、硒利生及锗-13... 本研究对比了预先给予小鼠多种无机和有机含金属(Zn,Se,Ge,Bi和As)药物及中药十全大补膏等对顺铂致死毒性的影响。结果表明除复方甘铋镁、氧化锗及十全大补膏外,其余药物对顺铂的致死毒性均有一定保护作用。尤其是甘草锌、硒利生及锗-132对顺铂致死毒性有较好保护作用(P<0.01)。它们的效果优于其无机化合物硫酸锌、亚硒酸钠、氧化锗及药物次石瞄铋(0.05<P<0.1)。经金属硫蛋白(MT)测定结果表明硒利生的MT诱导作用最强(P<0.01),甘草锌次之(P<0.05),而锗-132无MT诱导作用(P>0.05)。这点恰与前两药的保护作用用最好,且以预先给药为佳;而后者预先绐药效果欠佳的结果相吻合。由此证明了在应用微量元素药物解救由顺铂引起的重金属中毒过程中,MT的保护作用是其中一个重要机制。 展开更多
关键词 金属硫蛋白 顺铂 甘草锌 硒利生
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The Content of Selenium and Other Ten Chemical Elements in Boletus Edulis from Bulgaria and Inhibition of Lipid Peroxidation
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作者 G. Bekyarov M. Kakalova +6 位作者 A. Iliev Tsv. Bekyarova G.V. Donchenko O.M. Palyvoda O.V. Vydiuk A.S.Dubovetskyi O.I. Kuzmenko 《Journal of Environmental Science and Engineering》 2011年第6期708-715,共8页
The goal of this study was to determine the content of such biological active metals as Se, Hg, AI, Cu, Zn, As, Cd, Pb, Mg, Ca and Fe in Boletus Edulis mushrooms and to study the effect of mushrooms as inhibitors of b... The goal of this study was to determine the content of such biological active metals as Se, Hg, AI, Cu, Zn, As, Cd, Pb, Mg, Ca and Fe in Boletus Edulis mushrooms and to study the effect of mushrooms as inhibitors of blood serum copper-initiated lipid peroxidation. The metals content was determined by ICP-OES technique and blood lipids peroxidation in vitro was assessed by thiobarbituric acid-reactive substances measurement. The dependency between quality and content of the determined biological active metals has been traced. Samples were analyzed of wild growing mushrooms Boletus Edulis from two mountain regions in Bulgaria. On the average the content of Se in Boletus Edulis was found to be 25 mg/kg dried mushroom, this content being higher in tubules than in fleshy part. We found that Boletus Edulis mushrooms inhibited lipid peroxidation in the concentration dependent manner. The effective concentration of Boletus Edulis is in 5 times lower compared to the concentration of Cantharellus Cibarius resulting in similar lipid peroxidation inhibition. This effect can be explained by 56 times higher content of Se and by 1.5 and 3 times lower content of such initiators of lipid peroxidation as Cu and Fe in Boletus Edulis compared to Cantharellus Cibarius. A system with a source of infrared radiation heating, developed by authors, was used for the mushroom mineralization. We conclude that Boletus Edulis is an effective inhibitor of blood lipid peroxidation and in 5 times stronger rather than Cantharellus Cibarius. 展开更多
关键词 Boletus edulis ICP-OES heavy metals SELENIUM lipid peroxidation ANTIOXIDANTS
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