乳酸杆菌活菌制剂与甲硝唑类制剂治疗妊娠合并细菌性阴道病的影响分析

目的探讨乳酸杆菌活菌制剂与甲硝唑类制剂治疗妊娠合并细菌性阴道病的影响。方法选择我院60例2017.1~2018.2妊娠合并细菌性阴道病患者。随机分组,对照组采取甲硝唑类制剂治疗,联合组则采取甲硝唑类制剂+乳酸杆菌活菌制剂治疗。结果联合组治疗效率、实验室结果恢复至正常时间、病理转阴时间、自觉症状消失时间、症状积分、阴道清洁度相比较对照组更好,P<0.05。两组未见严重不良作用,P>0.05。结论甲硝唑类制剂+乳酸杆菌活菌制剂治疗妊娠合并细菌性阴道病可获得较好预后。

硝唑类脑病——2例病例报道并文献分析

目的:分析硝唑类脑病的特点及预后。方法:收集2例硝唑类脑病患者的临床资料,并搜集相关文献进行回顾性分析。结果:2例患者均表现为急性亚急性起病的小脑神经系统缺损症状;MRI显示损伤部位1例为胼胝体和小脑齿状核,1例为齿状核;停药后症状均迅速好转。检索文献获得硝唑类脑病患者69例临床资料,亚裔人为41例,首发临床症状中小脑功能缺损为62例,MRI累积部位齿状核63例,患者临床症状完全恢复65例。结论:硝唑类脑病多累及小脑、胼胝体及脑干,尤以亚裔人多发,预后相对较好。

妊娠合并细菌性阴道病采用乳酸杆菌活菌制剂与甲硝唑类制剂治疗的临床对比

目的对妊娠合并细菌性阴道病采用乳酸杆菌活菌制剂与甲硝唑类制剂治疗的临床效果进行研究分析。方法从我院妊娠合并细菌性阴道病患者中选取68例,采用乳酸杆菌活菌制剂治疗的34例患者为治疗组,采用甲硝唑类制剂治疗的34例患者为对照组,对比两组患者临床治疗效果。结果治疗组患者临床治疗总有效率为91.18%、早产发生率为5.88%、胎膜早破发生率为11.76%、未足月胎膜早破发生率为2.94%、低体质量儿发生率为2.94%、新生儿高疸发生率为11.76%;同对照组患者的70.59%、23.53%、32.35%、20.59%、20.59%和32.35%相比,P<0.05。结论在治疗妊娠合并细菌性阴道病临床上乳酸杆菌活菌制剂临床效果较为理想。

乳酸杆菌活菌制剂与甲硝唑类制剂治疗妊娠合并细菌性阴道病的临床疗效及复发率

目的:分析妊娠合并细菌性阴道病应用甲硝唑类制剂和乳酸杆菌活菌制剂治疗的临床疗效及复发率。方法:对本院2015年10月~2017年10月确诊妊娠合并细菌性阴道病82例患者临床资料进行分析,依据治疗方法不同分为两组,将行甲硝唑类制剂治疗41例作为对照组,将行乳酸杆菌活菌制剂治疗41例作为观察组,比较两组临床疗效和复发率。结果:观察组总有效率比对照组高,且胎膜早破率和早产率均比对照组低(P<0.05);两组停药两周后复发率对比无明显差异(P>0.05)。结论:妊娠合并细菌性阴道病应用乳酸杆菌活菌制剂治疗可改善临床症状,优化妊娠结局,且预后复发率较低,具有推广价值。

UPLC-MS/MS测定豆芽中16种硝唑和喹诺酮类抗生素残留的研究

建立三重四极杆液相色谱-串联质谱法,用以检测豆芽中16种硝唑和喹诺酮类抗生素残留的分析方法。前处理采用改进QuEChERS方法,样品经酸化乙腈提取、涡旋后,有效降低样品中复杂基质所带来的基质干扰,再经UPLC-MS/MS分析,以基质空白配标的内标法定量。16种硝唑和喹诺酮类抗生素残留为5~100μg/L范围内具有较好的线性关系,相关系数均大于0.99,加标水平在1,2,20μg/kg时,16种抗生素的回收率为60%~120%,相对标准差系数小于15%。该方法适用于豆芽中16种硝唑和喹诺酮类抗生素残留的分析检测。

Synthesis of nitrocarbazole compounds and their electrocatalytic oxidation of alcohol

Three compounds with nitrocarbazole frameworks were synthesized and their electrochemical reversibility as organic electrocatalysts was studied by cyclic voltammetry. The electrochemical reversibility and oxidation‐reduction potential of the compounds were greatly affected by their substituents. The oxidation‐reduction potential of the compound with an electron‐donating group was negative, while that of the compound with an electron‐withdrawing group on the carbazole framework was positive. The electrocatalytic oxidation activities of the nitrocarbazole compounds were investigated through cyclic voltammetry and controlled potential electrolysis at room tem‐perature. The electrocatalysts showed excellent selectivity for p‐methoxybenzyl alcohol, converting it to the corresponding aldehyde through electro‐oxidation with just 2.5 mol%of the electrocata‐lysts presented. The electrocatalysts maintained their excellent electroredox activity following re‐cycling.