Pitch based activated carbon fiber (PACF) was prepared, and influences of preparing condition such as activated temperature and time on the yield, specific surface area of PACF and its adsorption behavior towards n-bu...Pitch based activated carbon fiber (PACF) was prepared, and influences of preparing condition such as activated temperature and time on the yield, specific surface area of PACF and its adsorption behavior towards n-butanethiol were studied. The results showed that simple PACF could not remove n-butanethiol from n-hexane solution. Therefore, dispersion of suitable catalyst such as cobalt salt on PACF is needed. Cobalt salt dispersed PACF can remove n-butanethiol quickly.展开更多
Supplement of 1% lithocholic acid (LCA) in the diet for 5-9d resulted in elevated levels of the marker for liver damage AST and ALP activities in both FXR-null and wild-type female mice.The levels were clearly higher ...Supplement of 1% lithocholic acid (LCA) in the diet for 5-9d resulted in elevated levels of the marker for liver damage AST and ALP activities in both FXR-null and wild-type female mice.The levels were clearly higher in wild-type mice than in FXR-null mice,in spite of the diminished expression of a bile salt export pump(Bsep) in the latter.Consistent with liver toxicity marker activities,serum and liver levels of bile acide,particularly LCA and tauro LCA,were clearly higher in wild-type mice than in FXR-null mice after 1% LCA supplement.Marked increases in hepatic sulfating activity for LCA(5.5-fold) and hydroxysteroid sulfotransferase St2a(5.8-fold) were detected in liver of FXR-null mice.Liver St2a content was inversely correlated with levels of ALP.In contrast,microsomal LCA 6-hydroxylation was not increased and in fact lower in FXR-null mice compared in wild-type mice.Clear decreases in mRNA encoding Ntcp,Oatpl and Lst-1 transporters function in bild acid import were detected in LCA fed mice.These transporter levels are higher in FXR-null mice than in wild-type mice after 1% LCA supplement.No obvious changes were detected in the Mrp2,Mrp3 and Mrp4 mRNAs.These results indicate that hydroxysteroid sulfotransferase is reuired for protection against LCA-induced liver damage.展开更多
基金the Natural Science Foundation of Guangdong Province, China.
文摘Pitch based activated carbon fiber (PACF) was prepared, and influences of preparing condition such as activated temperature and time on the yield, specific surface area of PACF and its adsorption behavior towards n-butanethiol were studied. The results showed that simple PACF could not remove n-butanethiol from n-hexane solution. Therefore, dispersion of suitable catalyst such as cobalt salt on PACF is needed. Cobalt salt dispersed PACF can remove n-butanethiol quickly.
文摘Supplement of 1% lithocholic acid (LCA) in the diet for 5-9d resulted in elevated levels of the marker for liver damage AST and ALP activities in both FXR-null and wild-type female mice.The levels were clearly higher in wild-type mice than in FXR-null mice,in spite of the diminished expression of a bile salt export pump(Bsep) in the latter.Consistent with liver toxicity marker activities,serum and liver levels of bile acide,particularly LCA and tauro LCA,were clearly higher in wild-type mice than in FXR-null mice after 1% LCA supplement.Marked increases in hepatic sulfating activity for LCA(5.5-fold) and hydroxysteroid sulfotransferase St2a(5.8-fold) were detected in liver of FXR-null mice.Liver St2a content was inversely correlated with levels of ALP.In contrast,microsomal LCA 6-hydroxylation was not increased and in fact lower in FXR-null mice compared in wild-type mice.Clear decreases in mRNA encoding Ntcp,Oatpl and Lst-1 transporters function in bild acid import were detected in LCA fed mice.These transporter levels are higher in FXR-null mice than in wild-type mice after 1% LCA supplement.No obvious changes were detected in the Mrp2,Mrp3 and Mrp4 mRNAs.These results indicate that hydroxysteroid sulfotransferase is reuired for protection against LCA-induced liver damage.
