Aim: To evaluate the effectiveness of intravenous magnesium sulphate in the tr eatment of acute asthmatic attacks in children by meta-analysis. Methods: A sys tematic and comprehensive search of the literature was per...Aim: To evaluate the effectiveness of intravenous magnesium sulphate in the tr eatment of acute asthmatic attacks in children by meta-analysis. Methods: A sys tematic and comprehensive search of the literature was performed to identify con trolled clinical trials of magnesiumsulphate in paediatric acute asthma which ev aluated outcomes of hospitalisation or short term pulmonary function tests or sy mptom scores. Unpublished data were searched by personal contacts with authors a nd specialists. Two reviewers independently assessed trial qualities and synthes ised data. Heterogeneity among studies was evaluated by the Cochrane Q test. Out come data were pooled by random or fixed effect models depending on presence or absence of heterogeneity. Results: Five randomised placebo controlled trials inv olving a total of 182 patients were identified. They compared intravenous magnes ium sulphate to placebo in treating paediatric patients with moderate to severe asthmatic attacks in the emergency department, with co-therapies of inhaled β2 agonists and systemic steroids. The studies were of high quality with results j udged to be valid. Four studies showed that magnesium sulphate was effective, wh ile one study found it ineffective. There was no significant heterogeneity in th e primary outcome of hospitalisation. In the fixed effect model, magnesium sulph ate is effective in preventing hospitalisation (OR 0.290, 95%CI 0.143 to 0.5 89). The number needed to treat is 4 (95%CI 3 to 8). Secondary outcomes of shor t term pulmonary function tests and clinical symptom scores also showed signific ant improvement. Conclusion: Intravenous magnesium sulphate probably provides ad ditional benefit in moderate to severe acute asthma in children treated with bro nchodilators and steroids.展开更多
扭转型室性心动过速(Torsade de Pointes,以下简称TDP)临床上并非少见,国内外文献曾屡有报道。但静脉滴注硫酸镁治疗TDP的报道则不多。现将笔者经治的两例报告如下: 倒1,胡×,女,28岁,因胸闷心慌三天于1986年7月12日入院。病前两周...扭转型室性心动过速(Torsade de Pointes,以下简称TDP)临床上并非少见,国内外文献曾屡有报道。但静脉滴注硫酸镁治疗TDP的报道则不多。现将笔者经治的两例报告如下: 倒1,胡×,女,28岁,因胸闷心慌三天于1986年7月12日入院。病前两周曾有明显上呼吸道感染史。查体:T37.1℃,P120次/分。展开更多
文摘Aim: To evaluate the effectiveness of intravenous magnesium sulphate in the tr eatment of acute asthmatic attacks in children by meta-analysis. Methods: A sys tematic and comprehensive search of the literature was performed to identify con trolled clinical trials of magnesiumsulphate in paediatric acute asthma which ev aluated outcomes of hospitalisation or short term pulmonary function tests or sy mptom scores. Unpublished data were searched by personal contacts with authors a nd specialists. Two reviewers independently assessed trial qualities and synthes ised data. Heterogeneity among studies was evaluated by the Cochrane Q test. Out come data were pooled by random or fixed effect models depending on presence or absence of heterogeneity. Results: Five randomised placebo controlled trials inv olving a total of 182 patients were identified. They compared intravenous magnes ium sulphate to placebo in treating paediatric patients with moderate to severe asthmatic attacks in the emergency department, with co-therapies of inhaled β2 agonists and systemic steroids. The studies were of high quality with results j udged to be valid. Four studies showed that magnesium sulphate was effective, wh ile one study found it ineffective. There was no significant heterogeneity in th e primary outcome of hospitalisation. In the fixed effect model, magnesium sulph ate is effective in preventing hospitalisation (OR 0.290, 95%CI 0.143 to 0.5 89). The number needed to treat is 4 (95%CI 3 to 8). Secondary outcomes of shor t term pulmonary function tests and clinical symptom scores also showed signific ant improvement. Conclusion: Intravenous magnesium sulphate probably provides ad ditional benefit in moderate to severe acute asthma in children treated with bro nchodilators and steroids.
文摘扭转型室性心动过速(Torsade de Pointes,以下简称TDP)临床上并非少见,国内外文献曾屡有报道。但静脉滴注硫酸镁治疗TDP的报道则不多。现将笔者经治的两例报告如下: 倒1,胡×,女,28岁,因胸闷心慌三天于1986年7月12日入院。病前两周曾有明显上呼吸道感染史。查体:T37.1℃,P120次/分。
