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也谈什么是发表 被引量:6
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作者 钱寿初 《编辑学报》 CSSCI 北大核心 2001年第6期359-360,共2页
由于网上电子文本的增加 ,编辑、审稿公开、透明 ,发表不再是传统意义上一个过程的终结 ,而是一个延续交流、补充、修正、完善。电子文本可称“软发表” ,传统发表为“硬发表” ,两者不可或缺。电子文本服务器发布的论文如何加强审稿。
关键词 电子文本 发表 硬发表 论文审稿 网络 出版工作
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High expressions of caveolins on the proliferating bile ductules in primary biliary cirrhosis 被引量:4
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作者 Hiroaki Yokomori Masaya Oda +4 位作者 Go Wakabayashi Masaki Kitajima Kazunori Yoshimura Masahiko Nomura Toshifumi Hibi 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第24期3710-3713,共4页
AIM: An increase in bile ductular structures is observed in diverse human liver diseases, especially in primary biliary cirrhosis (PBC). These structures harbor the progenitor cell component of the liver. Caveolins ar... AIM: An increase in bile ductular structures is observed in diverse human liver diseases, especially in primary biliary cirrhosis (PBC). These structures harbor the progenitor cell component of the liver. Caveolins are cholesterol-binding proteins involved in the regulation of several intracellular processes including cholesterol transport. This study aims to examine the role of caveolin in PBC.METHODS: Immunohistochemical and Western blottingstudies were performed on human liver specimens obtained from patients with PBC and normal liver samples. The expression of caveolin (CAV)-1 and -2 was determined using specific antibodies.RESULTS: In normal liver, scanty immunostaining for CAV1 and -2 was observed in bile ductules. In PBC liver samples, the expression levels of CAV-1 and -2 were increased on proliferating bile ductules especially in stage 3 cases, but was sparse on interlobular bile duct in stage 1 specimens. Especially, the regenerating bile ductules at the interface of portal tracts and necrotic areas were immunostained intensely for CAV-1 and -2. These phenomena were confirmed by Western blot.CONCLUSION: The present results demonstrate increased expression of caveolins in proliferating bile ductules in PBC, which may be related to the homeostasis of cholesterol transport in regenerating bile ductules in PBC liver. 展开更多
关键词 Proliferating bile ductule CAVEOLIN Immunohis tochemistry Primary biliary cirrhosis
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Is osteoporosis a peculiar association with primary biliary cirrhosis? 被引量:7
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作者 Annarosa Floreani Andrea Mega +4 位作者 Valentina Camozzi Vincenzo Baldo Mario Plebani Patrizia Burra Giovanni Luisetto 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第34期5347-5350,共4页
AIM: (1) To compare the prevalence of osteoporosis (t-score ≤-2.5 SD) between stage IV PBC patients, and two groups of age- and sex-matched controls: one with hepatitis C virus (HCV)-related cirrhosis, and th... AIM: (1) To compare the prevalence of osteoporosis (t-score ≤-2.5 SD) between stage IV PBC patients, and two groups of age- and sex-matched controls: one with hepatitis C virus (HCV)-related cirrhosis, and the other one consisting of a group of healthy subjects from the general population, (2) to identify the main risk factors for the development of bone loss. METHODS: Thirty-five stage IV PBC patients (mean age 52.5±10 years), 49 females with HCV-related cirrhosis (mean age 52.9±5.8 years) and 33 healthy females (mean age 51.8±2.22 years) were enrolled in the study. Bone metabolism was evaluated by measuring serum calcium corrected for serum albumin (Ca corr.), 25-hydroxy vitamin D (25-OH vit D), parathyroid hormone, osteocaldn. Bone mineral density (BMD) was assessed at the lumbar spine by dual-photon X-ray absorptiometry. RESULTS: Osteoporosis was present in 5/35 PBC patients (14.2%) and in 7/49 HCV-related drrhotic patients (14.3%), without any statistical difference between the two groups. Among healthy control subjects, none had osteoporosis. No difference was found between the three groups in serum parameters of bone metabolism. Univariate analysis showed that menopausal state and low BMI were significantly correlated with osteoporosis. Multivariate regression analysis showed that menopausal status, BMI〈23, and old age were independent variables significantly correlated with osteoporosis. CONCLUSION: PBC in itself has no negative influence on BMD. End-stage liver disease patients carry a disease-specific risk for osteoporosis, but have an effective risk of bone loss in relation to individual potential risk for each patient. A practical message should be taken into account, that is, every effort should be made to prevent osteoporosis when a patient has simple osteopenia, or if it is a woman in or near menopausal age. 展开更多
关键词 OSTEOPOROSIS Primary biliary cirrhosis HCV infection
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