Schiff base derived from amino acid and aldehrde or ketone is an important ligand,which coordinate with metal to form complexes that possess excellent capabilities.The studies of the synthesis approach,biological prop...Schiff base derived from amino acid and aldehrde or ketone is an important ligand,which coordinate with metal to form complexes that possess excellent capabilities.The studies of the synthesis approach,biological properties,catalystal activity and resisting O2-capability in recent years have been summarized in this paper.Moreover some prospects in the future have been given.展开更多
One novel complex of （）99mTc-salicylidene-tyrosine Schiff base was designed and synthesized, and its biodistribution was investigated. The theoretical simulation revealed that the cis- and trans-（isomers） might co...One novel complex of （）99mTc-salicylidene-tyrosine Schiff base was designed and synthesized, and its biodistribution was investigated. The theoretical simulation revealed that the cis- and trans-（isomers） might co-exist in aqueous solution. A yield higher than 90% under the optimal condition of synthesis was obtained. Good water-solubility was demonstrated. Very little uptakes in muscle, brain, heart and S-180 sarcoma, as well as very rapid blood clearance were revealed in mice. Good accumulation in bone was shown. At 1 h postinjection the bone uptake was 10.9%ID/g. At 3 and 5 h postinjection, bone-to-muscle ratios were 19.0 and 9.3, and bone-to-blood ratios were 31.6 and 28.9, respectively. The result indicates a bone imaging potency of the complex.展开更多
The influences of magnetic fields on the biocatalytic properties of Schiff base mono- and dinuclear complexes for the monooxygenation of cyclohexane by PhIO were studied. It was found that the catalytic activities of ...The influences of magnetic fields on the biocatalytic properties of Schiff base mono- and dinuclear complexes for the monooxygenation of cyclohexane by PhIO were studied. It was found that the catalytic activities of these catalysts increase with the increase of the outside magnetic field intensity used, and the effects of magnetic field on the catalytic properties of these dinuclear complexes generally increase with the increase of the number of unpaired d electrons of the metal ion and the magnetic exchange between the two metals in these dinuclear complexes. Furthermore, it was found that the effect of magnetic field on the iron complex was greater than that on the other metallic complexes, and the effect of magnetic field on the mononuclear complex was greater than that on the dinuclear complex.展开更多
文摘Schiff base derived from amino acid and aldehrde or ketone is an important ligand,which coordinate with metal to form complexes that possess excellent capabilities.The studies of the synthesis approach,biological properties,catalystal activity and resisting O2-capability in recent years have been summarized in this paper.Moreover some prospects in the future have been given.
文摘One novel complex of （）99mTc-salicylidene-tyrosine Schiff base was designed and synthesized, and its biodistribution was investigated. The theoretical simulation revealed that the cis- and trans-（isomers） might co-exist in aqueous solution. A yield higher than 90% under the optimal condition of synthesis was obtained. Good water-solubility was demonstrated. Very little uptakes in muscle, brain, heart and S-180 sarcoma, as well as very rapid blood clearance were revealed in mice. Good accumulation in bone was shown. At 1 h postinjection the bone uptake was 10.9%ID/g. At 3 and 5 h postinjection, bone-to-muscle ratios were 19.0 and 9.3, and bone-to-blood ratios were 31.6 and 28.9, respectively. The result indicates a bone imaging potency of the complex.
文摘The influences of magnetic fields on the biocatalytic properties of Schiff base mono- and dinuclear complexes for the monooxygenation of cyclohexane by PhIO were studied. It was found that the catalytic activities of these catalysts increase with the increase of the outside magnetic field intensity used, and the effects of magnetic field on the catalytic properties of these dinuclear complexes generally increase with the increase of the number of unpaired d electrons of the metal ion and the magnetic exchange between the two metals in these dinuclear complexes. Furthermore, it was found that the effect of magnetic field on the iron complex was greater than that on the other metallic complexes, and the effect of magnetic field on the mononuclear complex was greater than that on the dinuclear complex.
