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生产、碳俘获与群体依赖——英国碳中和进展的国际政治经济学分析 被引量:1
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作者 马昊原 《欧洲研究》 CSSCI 北大核心 2023年第4期123-150,I0005,共29页
英国在碳中和议题上向来扮演着较为活跃的角色,力图占据该领域的领导地位。在诸多讨论气候变化的国际场合,英国频繁督促他国采取更加有力的应对措施,并将自身作为行动标杆。其行为背后的核心支撑在于主流叙事架构下的优良历史表现,叠加... 英国在碳中和议题上向来扮演着较为活跃的角色,力图占据该领域的领导地位。在诸多讨论气候变化的国际场合,英国频繁督促他国采取更加有力的应对措施,并将自身作为行动标杆。其行为背后的核心支撑在于主流叙事架构下的优良历史表现,叠加繁复的话语修辞用以包装。然而,国际社会已经开始质疑英国及其他发达国家的宣传是否符合实际情况,但对此进行系统分析的学术研究和理论框架仍相对匮乏。鉴于气候变化与碳中和的核心属性,本文拟以国际政治经济学的生产概念为切入点,建立一个旨在探究英国碳中和进展的分析框架,揭示其脱碳转型并非像宣传的那样顺利,而是陷入层层泥淖。基于这一认知,本文将进一步从国家与社会的互动分析中指出,碳俘获与群体依赖现象正在阻碍英国碳中和进程的推进,并尝试从这一现象中挖掘有助于理论发展的实证经验。 展开更多
关键词 英国 中和 碳俘获 群体依赖 转型
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Folate receptor-mediated boron-10 containing carbon nanoparticles as potential delivery vehicles for boron neutron capture therapy of nonfunctional pituitary adenomas 被引量:8
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作者 DAI CongXin CAI Feng +14 位作者 HWANG Kuo Chu ZHOU YongMao ZHANG ZiZhu LIU XiaoHai MA SiHai YANG YaKun YAO Yong FENG Ming BAO XinJie LI GuiLin WEI JunJi JIAO YongHui WEI ZhenQing MA WenBin WANG RenZhi 《Science China(Life Sciences)》 SCIE CAS 2013年第2期163-173,共11页
Invasive nonfunctional pituitary adenomas (NFPAs) are difficult to completely resect and often develop tumor recurrence after initial surgery. Currently, no medications are clinically effective in the control of NFP... Invasive nonfunctional pituitary adenomas (NFPAs) are difficult to completely resect and often develop tumor recurrence after initial surgery. Currently, no medications are clinically effective in the control of NFPA. Although radiation therapy and radiosurgery are useful to prevent tumor regrowth, they are frequently withheld because of severe complications. Boron neutron capture therapy (BNCT) is a binary radiotherapy that selectively and maximally damages tumor cells without harming the surrounding normal tissue. Folate receptor (FR)-targeted boron-10 containing carbon nanoparticles is a novel boron delivery agent that can be selectively taken up by FR-expressing cells via FR-mediated endocytosis. In this study, FR-targeted boron-10 containing carbon nanoparticles were selectively taken up by NFPAs cells expressing FR but not other types of non-FR expressing pituitary adenomas. After incubation with boron-10 containing carbon nanoparticles and following irradiation with thermal neutrons, the cell viability of NFPAs was significantly decreased, while apoptotic cells were simultaneously increased. However, cells administered the same dose of FR-targeted boron-10 containing carbon nanoparticles without neutron irradiation or received the same neutron irradiation alone did not show significant decrease in cell viability or increase in apoptotic cells. The expression of Bcl-2 was down-regulated and the expression of Bax was up-regulated in NFPAs after treatment with FR-mediated BNCT. In conclusion, FR-targeted boron-10 containing carbon nanoparticles may be an ideal delivery system of boron to NFPAs ceils for BNCT. Furthermore, our study also provides a novel insight into therapeutic strategies for invasive NFPA refractory to conventional therapy, while exploring these new applications of BNCT for tumors, especially benign tumors. 展开更多
关键词 nonfunctional pituitary adenomas folate receptor NANOPARTICLES boron neutron capture therapy
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