Superparamagnetic poly(acrylamide) magnetic nanogels produced via photochemical method have been developed. After Hoffmann degradation of carbonyl, the nanogels with amino groups, or poly(acrylamide-vinyl amine) magne...Superparamagnetic poly(acrylamide) magnetic nanogels produced via photochemical method have been developed. After Hoffmann degradation of carbonyl, the nanogels with amino groups, or poly(acrylamide-vinyl amine) magnetic nanogels, were also obtained. And the magnetic nanogels were further modified by methoxy poly(ethylene glycol) (MPEG) for higher dispersibility and stability. The MPEG-modified magnetic nanogels were characterized by X-ray diffraction (XRD), photo correlation spectroscopy (PCS) and scanning electron microscopy (SEM), respectively. The MPEG-modified magnetic nanogels were labeled by 188Re radiopharmaceuticals and intra-venously injected into tails of mice in the presence and absence of a 0.5 T external magnetic field targeted on the bel-lies. The radioactivity distribution was monitored in vivo. In the absence of magnetic field, the radioactivity was mainly distributed in liver, spleen, kidney, stomach and lung. In the presence of the magnetic field, the radioactivity was mainly accumulated on the targeted point, verifying the magnetically targeted character.展开更多
锰和铼的阳离子卡宾配合物[π-CH(CO)MnCCH]SbCl(1)和[π-CH(CO)ReCCH]-BCl(2)分别与1-萘硒基锂,LiSeCH-1反应,生成锰和铼的萘硒基卡宾配合物[π-CH(CO)-MnC(CH)(SeCH-1)(3)和[π-CH(CO)ReC(CH)(SeCH-1)(4)及铼的烷基卡宾配合物[π-CH(C...锰和铼的阳离子卡宾配合物[π-CH(CO)MnCCH]SbCl(1)和[π-CH(CO)ReCCH]-BCl(2)分别与1-萘硒基锂,LiSeCH-1反应,生成锰和铼的萘硒基卡宾配合物[π-CH(CO)-MnC(CH)(SeCH-1)(3)和[π-CH(CO)ReC(CH)(SeCH-1)(4)及铼的烷基卡宾配合物[π-CH(CO)ReC(CH)(n-CH)(5).这些新卡宾配合物均经元素分析,IR,HNMR 和 MS 鉴定.展开更多
基金Supported by Science and Technology Commission of Shanghai Municipality (No.0352nm120) and the Knowledge Innovation Pro-ject of Chinese Academy of Sciences (No.90120310).
文摘Superparamagnetic poly(acrylamide) magnetic nanogels produced via photochemical method have been developed. After Hoffmann degradation of carbonyl, the nanogels with amino groups, or poly(acrylamide-vinyl amine) magnetic nanogels, were also obtained. And the magnetic nanogels were further modified by methoxy poly(ethylene glycol) (MPEG) for higher dispersibility and stability. The MPEG-modified magnetic nanogels were characterized by X-ray diffraction (XRD), photo correlation spectroscopy (PCS) and scanning electron microscopy (SEM), respectively. The MPEG-modified magnetic nanogels were labeled by 188Re radiopharmaceuticals and intra-venously injected into tails of mice in the presence and absence of a 0.5 T external magnetic field targeted on the bel-lies. The radioactivity distribution was monitored in vivo. In the absence of magnetic field, the radioactivity was mainly distributed in liver, spleen, kidney, stomach and lung. In the presence of the magnetic field, the radioactivity was mainly accumulated on the targeted point, verifying the magnetically targeted character.
文摘锰和铼的阳离子卡宾配合物[π-CH(CO)MnCCH]SbCl(1)和[π-CH(CO)ReCCH]-BCl(2)分别与1-萘硒基锂,LiSeCH-1反应,生成锰和铼的萘硒基卡宾配合物[π-CH(CO)-MnC(CH)(SeCH-1)(3)和[π-CH(CO)ReC(CH)(SeCH-1)(4)及铼的烷基卡宾配合物[π-CH(CO)ReC(CH)(n-CH)(5).这些新卡宾配合物均经元素分析,IR,HNMR 和 MS 鉴定.
